(4-METHYLPYRIDIN-3-YL)METHANOL Chemical Properties

Melting point:

44-46℃

Boiling point:

125-127℃ (1.5-2.0 Torr)

Density 

1.092±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.71±0.10(Predicted)

Appearance

White to yellow Solid

Safety Information

HS Code 

2933399990

(4-METHYLPYRIDIN-3-YL)METHANOL Usage And Synthesis

Synthesis

The general procedure for the synthesis of 3-hydroxymethyl-4-methylpyridine from 4-methylpyridine-3-carboxylic acid was as follows: a tetrahydrofuran solution (15 mL) of 1.0 mol/L borane-tetrahydrofuran complex was slowly added to a tetrahydrofuran solution (15 mL) containing 4-methylnicotinic acid (686 mg), followed by a heating and refluxing for 2 hours. Upon completion of the reaction, 2.0 mol/L hydrochloric acid solution (5 mL) was added dropwise to the reaction system and refluxing was continued for 0.5 hours. After the reaction mixture was cooled to room temperature, it was extracted with ethyl acetate. The organic phase was washed sequentially with aqueous sodium carbonate solution and saturated aqueous sodium chloride solution, followed by drying with anhydrous sodium sulfate. After the solvent was removed by distillation under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent ratio: ethyl acetate:methanol=1:0→9:1), and the target product (4-methylpyridin-3-yl)methanol (270 mg) was finally obtained as a white solid. Mass spectrum (ESI m/z): 124 (M+H). Retention time (min): 1.11.

References

[1] Patent: US2016/168139, 2016, A1. Location in patent: Paragraph 0958-0962

(4-METHYLPYRIDIN-3-YL)METHANOL(4664-27-1)Related Product Information

• 4-Deoxypyridoxine hydrochloride
• 4-Pyridoxic acid
• PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
• DIETHYL 3 4-PYRIDINEDICARBOXYLATE 97
• Pyridoxine hydrochloride
• 4-(Trifluoromethyl)nicotinic acid
• Pyridoxal hydrochloride
• Pyridoxal 5'-phosphate monohydrate
• Pyridoxine
• Pyridoxamine dihydrochloride
• ETHYL 2,4-DIMETHYLPYRIDINE-3-CARBOXYLATE
• 3,4-Pyridinedicarboxylic acid
• 4-deoxypyridoxine
• DIMETHYL 4-(4-METHOXYPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE
• 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE
• PYRIDOXAMINE-5'-PHOSPHATE
• TRI-ACETYL PYRIDOXINE
• PYRIDOXYLIDENE-L-ISOLEUCINE POTASSIUM SALT