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CETUXIMAB

Basic information Safety Supplier Related

CETUXIMAB Basic information

Product Name:
CETUXIMAB
Synonyms:
  • CETUXIMAB
  • Hsdb 7454
  • Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 gamma1-chain), disulfide with human-mouse monoclonal C225 kappa-chain, dimer
  • Unii-pqx0D8J21j
  • CetuxiMab(C225)
  • EGFR antibody
  • IMC 225
  • Cetuximab - Buffer solution
CAS:
205923-56-4
MF:
C107H179N35O36S7
MW:
2756.23406
Mol File:
205923-56-4.mol
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CETUXIMAB Chemical Properties

storage temp. 
Store at 4°C, do not freeze
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Safety Information

Hazardous Substances Data
205923-56-4(Hazardous Substances Data)
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CETUXIMAB Usage And Synthesis

Description

Cetuximab, a human/mouse chimeric monoclonal antibody that blocks the EGFR, was launched for use in combination with irinotecan in the treatment of patients with colorectal cancer who no longer respond to standard chemotherapy treatment with irinotecan. Cetuximab is obtained by chimerization of M225, a murine anti-EGFR antibody; specifically heavy and light chains of the murine antibody are cloned and adapted for expression with constant regions of the human kappa light chain and human gamma1 heavy chain. It is produced by mammalian (suspension) cells in serum-free medium, purified by protein A affinity chromatography, ion-exchange chromatography, and gel filtration. Cetuximab binds specifically to EGFR on both normal and tumor cells. Overexpression of the human EGFR is detected in many cancers, including those of the colon and rectum. The binding of cetuximab to EGFR prevents growth factors from binding to the receptor, thereby inhibiting cell growth and inducing apoptosis. The therapeutic regimen of cetuximab consists of an initial loading dose of 400 mg/m2 administered as a 120-min IV infusion, followed by weekly maintenance dose of 250 mg/m2 infused over 60 min. The steady-state plasma concentrations of cetuximab are reached by the third weekly infusion and the mean elimination half-life is 114 h. Cetuximab is eliminated by binding to EGFRs in various tissues, followed by internalization of the antibody- EGFR complex. Systemic clearance of the antibody is saturated at higher doses, and this appears to correlate with saturation of EGFR binding. In a multicenter clinical trial in more than 300 patients with advanced metastatic colorectal cancer, combination therapy with cetuximab and irinotecan produced response in more than half of the patients, shrinking tumors in 23% and stopping tumor growth in an additional 33% of the patients. The most common adverse reactions associated with cetuximab were acneform rash, asthenia/malaise, fever, nausea, abdominal pain, constipation and vomiting. Serious adverse events such as infusion reaction, fever, sepsis, kidney failure, dehydration and diarrhea were experienced by <10% of the patients.

Originator

ImClone (US)

Uses

Treatment of EGF receptor-expressing cancers (monoclonal antibod.

brand name

Erbitux

Clinical Use

Monoclonal antibody:
Treatment of EGFR-expressing metastatic colorectal cancer in combination with irinotecan after failure of irinotecan-including cytotoxic therapy

Treatment of head and neck cancer

Toxicology

The majority of skin toxicities were mild to moderate, symptomatic treatments were effective in controlling them. The skin discomfort caused by cetuximab can affect the quality of life temporarily; with long term treatment, severity of skin toxicity may decrease.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid with live vaccines.

Metabolism

Several pathways have been described that may contribute to the metabolism of antibodies. All of these pathways involve the biodegradation of the antibody to smaller molecules, i.e. small peptides or amino acids.

CETUXIMABSupplier

Hefei Hirisun Pharmatech Co., Ltd. Gold
Tel
+86-0551-62678551 +86-15056975894
Email
sales@hirisunpharm.com
Taizhou KEDE Chemical Co., Ltd Gold
Tel
0576-84613060 13093829633
Email
sales@kedechemical.com
Hubei wei shi reagent group ltd., company Gold
Tel
027-027-59102966 18717199209
Email
2853877583@qq.com
Shanghai Aladdin Biochemical Technology Co.,Ltd. Gold
Tel
+86-18521732826
Email
market@aladdin-e.com
Shanghai Hanjing Chemicals Co., Ltd. Gold
Tel
021-54285032 13641685631
Email
gerry.shu@hanjingchemicals.com