Basic information Safety Supplier Related

Benzyl-PEG6-azide

Basic information Safety Supplier Related

Benzyl-PEG6-azide Basic information

Product Name:
Benzyl-PEG6-azide
Synonyms:
  • Benzyl-PEG6-azide
  • Benzyl-PEG6-N3
  • CAS_86770-73-2
  • 2,5,8,11,14,17-Hexaoxanonadecane, 19-azido-1-phenyl-
CAS:
86770-73-2
MF:
C19H31N3O6
MW:
397.47
Mol File:
86770-73-2.mol
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Benzyl-PEG6-azide Usage And Synthesis

Biological Activity

Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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