2-[2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Chemical Properties

Boiling point:

473.6±40.0 °C(Predicted)

Density 

1.097±0.06 g/cm3(Predicted)

refractive index 

1.4920 to 1.4960

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DMSO, DCM, DMF

pka

14.36±0.10(Predicted)

form 

clear liquid

color 

Colorless to Light yellow

InChI

InChI=1S/C19H32O7/c20-6-7-21-8-9-22-10-11-23-12-13-24-14-15-25-16-17-26-18-19-4-2-1-3-5-19/h1-5,20H,6-18H2

InChIKey

VVBQKDDPSXBMMZ-UHFFFAOYSA-N

SMILES

C(O)COCCOCCOCCOCCOCCOCC1=CC=CC=C1

CAS DataBase Reference

24342-68-5

Safety Information

HS Code 

2909.30.6000

2-[2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Usage And Synthesis

Description

Benzyl-PEG7-alcohol is a PEG chain containing a benzyl protecing group and a primary alcohol group. The benzyl is an alcohol protecting group and can be removed via hydrogenolysis. The alcohol group can react to further derivatize the compound. The hydrophilic PEG chains increase the water solubility of the compound in aqueous media. Longer PEG chains have better water solubility properties relative to shorter PEG chains.

Uses

BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BnO-PEG6-OH is also a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

Biological Activity

BnO-PEG6-OH is a non-cleavable ADC linker containing 6-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

target

IC 50

Non-cleavable Linker; PEGs

References

[1] Shaoyun Xiang, et al. Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses there. Patent WO2016197946A1.
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

2-[2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL(24342-68-5)Related Product Information

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