Ald--Ph-PEG6-acid Chemical Properties

Boiling point:

682.4±55.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DMF

pka

4.28±0.10(Predicted)

form 

Viscous Liquid

color 

Colorless to light yellow

Ald--Ph-PEG6-acid Usage And Synthesis

Description

Ald-Ph-PEG6-acid is an aldehyde PEG reagent. The benzaldehyde group is reactive with hydrazide and aminooxy moiety. The terminal carboxylic acid can couple with primary amines in the presence of activators such as EDC or HATU to form a stable amide bond. PEG6 linker increases the solubility of compounds in aqueous media.

Uses

Ald-Ph-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Ald--Ph-PEG6-acid(2055013-55-1)Related Product Information

• Ald-Ph-PEG4-t-butyl ester
• Acid-PEG4-t-butyl ester
• Ald--Ph-PEG2-acid
• Ald-Ph-PEG4-acid
• Ald-Ph-PEG2-t-butyl ester
• Ald-PEG4-t-butyl ester
• Acid-PEG3-t-butyl ester
• Acid-PEG6-t-butyl ester
• Ald-PEG5-t-butyl ester
• Acid-PEG5-t-butyl ester
• Ald-Ph-PEG2-amine
• m-PEG4-benzaldehyde
• Ald--Ph-PEG2-NHS
• Ald-PEG4-NHS ester
• Ald-Ph-PEG6-t-butyl ester
• Ald-Ph-PEG3-Azide
• m-PEG4-CH2-aldehyde
• Ald-PEG5-Azide