Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Chemical Properties

Boiling point:

674.2±55.0 °C(Predicted)

Density 

1.440±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO (up to 25 mg/ml).

form 

White to off-white powder.

pka

4.01±0.19(Predicted)

color 

white

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

WGK Germany 

3

MSDS

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Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Usage And Synthesis

Description

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.

Uses

Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor.

References

1) Dolle et al. (1994) P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme; J.Med.Chem. 37 563

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