ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties

Boiling point:

342.2±37.0 °C(Predicted)

Density 

1.465±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

DMSO: 22 mg/mL, soluble

form 

solid

pka

12.07±0.20(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Usage And Synthesis

Uses

PETCM is a caspace-3 activator in cell extracts.

Definition

ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.

Biological Activity

petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].

storage

Room temperature

References

[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL(10129-56-3)Related Product Information

• AC-LEU-GLU-HIS-ASP-AMC
• Z-PHE-DL-ALA-FLUOROMETHYLKETONE
• AC-VDVAD-PNA
• Z-VAD-FMK
• AC-YVAD-PNA
• CASPASE INHIBITOR3
• AC-VEID-AMC
• Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
• Z-YVAD-AFC
• AC-VDVAD-CHO
• AC-DEVD-AFC
• PAC1
• AC-DEVD-CHO
• AC-LEHD-AFC
• AC-LEU-GLU-THR-ASP-AFC
• 4-Pyridineethanol
• 4-(3-Chloropropyl)pyridine hydrochloride
• ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL