Basic information Safety Supplier Related

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

Basic information Safety Supplier Related

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Basic information

Product Name:
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
Synonyms:
  • PETCM
  • APOPTOSIS ACTIVATOR I
  • ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
  • 1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE
  • 1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL
  • a-(Trichloromethyl)-4-pyridineethanol
  • α-(Trichloromethyl)-4-pyridineethanol
  • α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
CAS:
10129-56-3
MF:
C8H8Cl3NO
MW:
240.51
Product Categories:
  • Caspase/Related products.
Mol File:
10129-56-3.mol
More
Less

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties

Boiling point:
342.2±37.0 °C(Predicted)
Density 
1.465±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 22 mg/mL, soluble
form 
solid
pka
12.07±0.20(Predicted)
color 
Light yellow to light brown
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3

MSDS

More
Less

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Usage And Synthesis

Uses

PETCM is a caspace-3 activator in cell extracts.

Definition

ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.

Biological Activity

petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].

storage

Room temperature

References

[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOLSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
VDM Biochemicals
Tel
0330-2528181
Email
sales@vdmbio.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com