ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Basic information
- Product Name:
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- Synonyms:
-
- PETCM
- APOPTOSIS ACTIVATOR I
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- 1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE
- 1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL
- a-(Trichloromethyl)-4-pyridineethanol
- α-(Trichloromethyl)-4-pyridineethanol
- α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
- CAS:
- 10129-56-3
- MF:
- C8H8Cl3NO
- MW:
- 240.51
- Product Categories:
-
- Caspase/Related products.
- Mol File:
- 10129-56-3.mol
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties
- Boiling point:
- 342.2±37.0 °C(Predicted)
- Density
- 1.465±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: 22 mg/mL, soluble
- form
- solid
- pka
- 12.07±0.20(Predicted)
- color
- Light yellow to light brown
MSDS
- Language:English Provider:SigmaAldrich
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Usage And Synthesis
Uses
PETCM is a caspace-3 activator in cell extracts.
Definition
ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.
Biological Activity
petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].
storage
Room temperature
References
[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.
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ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL(10129-56-3)Related Product Information
- AC-LEU-GLU-HIS-ASP-AMC
- Z-PHE-DL-ALA-FLUOROMETHYLKETONE
- AC-VDVAD-PNA
- Z-VAD-FMK
- AC-YVAD-PNA
- CASPASE INHIBITOR3
- AC-VEID-AMC
- Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
- Z-YVAD-AFC
- AC-VDVAD-CHO
- AC-DEVD-AFC
- PAC1
- AC-DEVD-CHO
- AC-LEHD-AFC
- AC-LEU-GLU-THR-ASP-AFC
- 4-Pyridineethanol
- 4-(3-Chloropropyl)pyridine hydrochloride
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL