C-REACTIVE PROTEIN, HUMAN Chemical Properties

Boiling point:

~100 °C

storage temp. 

2-8°C

solubility 

aqueous buffer: soluble

form 

buffered aqueous solution

biological source

rabbit

Water Solubility 

water: soluble

Safety Information

Hazard Codes 

Xn,B

Risk Statements 

20/21/22-32-21/22-22

Safety Statements 

36/37-7

RIDADR 

UN 3264 8 / PGIII

WGK Germany 

-

HS Code 

3504009000

MSDS

• Language:English Provider:SigmaAldrich

C-REACTIVE PROTEIN, HUMAN Usage And Synthesis

Uses

For immunological applications in the preparation of antisera

Uses

Human C-Reactive Protein ELISA Kit has been used to measure C-reactive protein (CRP) levels in serum.

General Description

Recombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca²⁺-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.

Biochem/physiol Actions

C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.

Description

Human CRP produced in Human plasma having a molecular mass of 114 kDa.
It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease.

Source

Human Plasma

Background

CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically ( up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.

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