C-REACTIVE PROTEIN, HUMAN Chemical Properties

Boiling point:

~100 °C

storage temp. 

2-8°C

form 

buffered aqueous solution

Safety Information

Hazard Codes 

Xn,B

Risk Statements 

20/21/22-32-21/22-22

Safety Statements 

36/37-7

RIDADR 

UN 3264 8 / PGIII

WGK Germany 

-

HS Code 

3504009000

MSDS

• Language:English Provider:SigmaAldrich

C-REACTIVE PROTEIN, HUMAN Usage And Synthesis

Uses

For immunological applications in the preparation of antisera

Uses

Human C-Reactive Protein ELISA Kit has been used to measure C-reactive protein (CRP) levels in serum.

General Description

Recombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca²⁺-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.

Biochem/physiol Actions

C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.

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