Basic information Safety Supplier Related

ML246

Basic information Safety Supplier Related

ML246 Basic information

Product Name:
ML246
Synonyms:
  • ML246
  • Metarrestin (ML246)
  • Cyclohexanol, 4-[4,7-dihydro-4-imino-5,6-diphenyl-7-(phenylmethyl)-3H-pyrrolo[2,3-d]pyrimidin-3-yl]-, trans-
  • trans-4-(7-benzyl-4-imino-5,6-diphenylpyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol
  • ML-246,breast,perinucleolar,HeLa,Metarrestin,nucleolar,Inhibitor,DNA/RNA Synthesis,PANC1,orally,metastatic,transcription,inhibit,eEF1A2,PC3M,compartment,pancreatic,ML 246
  • trans-4-(7-Benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol
  • Metarrestin, 10 mM in DMSO
  • Metarrestin (ML246) ，S3472
CAS:
1443414-10-5
MF:
C31H30N4O
MW:
474.6
Mol File:
1443414-10-5.mol
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ML246 Chemical Properties

Boiling point:
651.7±65.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 31.25 mg/mL (65.84 mM)
form 
Solid
pka
14.93±0.40(Predicted)
color 
White to off-white
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ML246 Usage And Synthesis

Uses

ML246 is a perinucleolar compartment (PNC) modulator/ Inhibitor.

in vivo

Metarrestin (ML246; 5-25 mg/kg; IP; once daily; continuing for six weeks) displays a decrease in metastatic burden in both liver (p <0.01) and lung with 25 mg/kg[2].
? Metarrestin (drug-infused chow; 10 mg/kg; 70 ppm) extends survival in the NSG PANC1 pancreatic cancer metastasis mice model[2].
? Metarrestin (5, 25 mg/kg; ip; for 4 additional week) reduces metastasis of prostate cancer (PC3M) and growth of metastatic breast cancer PDX mice models[2].
? Metarrestin (5 and 25 mg/kg; IP) has a half-life of 4.6 to 5.5 hours[2].

Animal Model:NOD/IL2 gamma (null) PANC1 mice over primary tumor tissues[2]
Dosage:5 and 25 mg/kg
Administration:IP; once daily; continuing for six weeks
Result:Displayed a decrease in metastatic burden in both liver (p <0.01) and lung with 25 mg/kg.
Demonstrated a significant reduction of perinucleolar compartment prevalence in metastatic and primary tumor tissues.
Animal Model:Female BALB/c mice[2]
Dosage:5 and 25 mg/kg (Pharmacokinetic Analysis)
Administration:IP
Result:Indicated good exposure, distribution, and tolerability in vivo, with a half-life of 4.6 to 5.5 hours.

ML246Supplier

Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Email
2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Email
sales@rechemscience.com
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ML246(1443414-10-5)Related Product Information