N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID Chemical Properties

Boiling point:

410℃

Density 

1.18

refractive index 

1.4620 (estimate)

Flash point:

202℃

storage temp. 

2-8°C(protect from light)

pka

3.36±0.20(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C11H20N2O4/c1-10(2,3)17-9(16)13-11(8(14)15)4-6-12-7-5-11/h12H,4-7H2,1-3H3,(H,13,16)(H,14,15)

InChIKey

RAENIWWUAIMXSI-UHFFFAOYSA-N

SMILES

N1CCC(NC(OC(C)(C)C)=O)(C(O)=O)CC1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

MSDS

• Language:English Provider:ACROS

N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White to off-white crystalline powder

Uses

N-Boc-amino-piperidinyl-1,1-carboxylic acid is used in pharmaceutical synthesis.

Synthesis

The synthesis of N-BOC-amino-piperidinyl-1,1-carboxylic acid usually starts with piperidine-4-carboxylic acid. Sodium bicarbonate and di-tert-butyl dicarbonate (Boc₂O) are added to the reaction system, and the amino protection reaction is carried out in a solvent such as tetrahydrofuran (THF) or 1,4-dioxane. The reaction is stirred at room temperature for several hours until the reaction is completed. Subsequently, the crude product is obtained by steps such as ethyl acetate extraction, pH adjustment of the aqueous phase, drying of the organic phase and reduced pressure concentration, and then purified by column chromatography using a mixed solvent of ethyl acetate and n-hexane as an eluent to finally obtain a high-purity target compound.

N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID(252720-31-3)Related Product Information

• TERT-BUTYL ISOCYANIDE
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Tris(2,4-pentanedionato)chroMiuM(III)
• Benzyl isocyanide
• COBALT(II) ACETYLACETONATE
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• METHYL ISOCYANOACETATE
• Ferric acetylacetonate
• Cupric acetylacetonate
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• PHENYLSELENOL
• N-BUTYLISOCYANIDE
• Tosylmethyl isocyanide
• SALCOMINE
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• Aluminum acetylacetonate
• Ethyl isocyanoacetate