VUF 10166 Chemical Properties

Boiling point:

389.6±42.0 °C(Predicted)

Density 

1.279±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

≥26.3 mg/mL in EtOH; insoluble in H2O; ≥38.8 mg/mL in DMSO

form 

solid

pka

6.55±0.42(Predicted)

color 

Light yellow to yellow

VUF 10166 Usage And Synthesis

Uses

VUF 10166 is a 5-HT3 receptor antagonist. VUF 10166 exhibits partial agonist activity at 5-HT3A receptors at higher concentrations. VUF 10166 is also histamine H4 receptor antagonist.

Biological Activity

vuf10166 is a novel, potent and competitive antagonist for 5-ht3a receptor with ki of 0.04 nm, its affinity at 5-ht3ab receptor is significantly lower.

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