Basic information Safety Supplier Related

2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide

Basic information Safety Supplier Related

2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide Basic information

Product Name:
2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Synonyms:
  • 2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
  • VU0134992
  • Acetamide, 2-[2-bromo-4-(1-methylethyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)-
  • natriuresis,hypertension,electrophysiology,whole-cell,selective,VU0134992,diuresis,Potassium Channel,oral,VU-0134992,patch-clamp,KcsA,Inhibitor,inhibit,Kir4.1,kaliuresis
  • 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
  • VU0134992, 10 mM in DMSO
  • VU0134992 (VU 0134992)
CAS:
755002-90-5
MF:
C20H31BrN2O2
MW:
411.38
Mol File:
755002-90-5.mol
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2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide Chemical Properties

solubility 
Soluble to 100 mM in DMSO and to 100 mM in ethanol
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2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide Usage And Synthesis

Uses

VU0134992 is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV[1].

in vivo

VU0134992 (50-100 mg/kg; oral gavage) statistically significantly increased urinary Na+ as well as K+ excretion[1].

Animal Model:Male Sprague-Dawley rats (250-300 g)[1]
Dosage:50 and 100 mg/kg
Administration:Oral gavage
Result:Statistically significantly increased urinary Na+ as well as K+ excretion

storage

Store at -20°C

References

[1] Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937. DOI:10.1124/mol.118.112359

2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamideSupplier

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2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide(755002-90-5)Related Product Information