CASPASE-9 Chemical Properties

storage temp. 

-70°C

solubility 

PBS with 15% glycerol: 1units/μL

form 

lyophilized

Specific Activity

≥400units/mg protein

Safety Information

WGK Germany 

WGK 1

Storage Class

12 - Non Combustible Liquids

CASPASE-9 Usage And Synthesis

Biological Activity

When cells receive apoptotic stimuli, such as activation of the TNFα/Fas cell surface receptor, caspase 8 activation, Bid processing and its translocation to the mitochondria ensue. As a result mitochondria release cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP. The resultant complex recruits caspase 9 leading to its activation. It then cleaves downstream caspases such as caspase 3, 6, and 7, initiating the caspase cascade. Caspase 9 exhibits basal activity. It can be further activated via interaction of its N-terminal prodomain with the activator protein Apaf-1 in the presence of cytochrome c and dATP. Caspases have been implicated in many disorders including cancer, inflammatory disease, neurodegenerative diseases, stroke and myocardial infarction.

CASPASE-9(265294-58-4)Related Product Information

• COBALT(II) ACETYLACETONATE
• PHENYLSELENOL
• METHYL ISOCYANOACETATE
• N-BUTYLISOCYANIDE
• Tris(2,4-pentanedionato)chroMiuM(III)
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Tosylmethyl isocyanide
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• Ethyl isocyanoacetate
• Cupric acetylacetonate
• Aluminum acetylacetonate
• TERT-BUTYL ISOCYANIDE
• Benzyl isocyanide
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Ferric acetylacetonate
• PROTEASE