S-Methyl-L-thiocitrulline dihydrochloride
S-Methyl-L-thiocitrulline dihydrochloride Basic information
- Product Name:
- S-Methyl-L-thiocitrulline dihydrochloride
- Synonyms:
-
- S-MTC dihydrochloride
- JNZHDSKJUXGYRG-XRIGFGBMSA-N
- (S,E)-2-Amino-5-((amino(methylthio)methylene)amino)pentanoic acid dihydrochloride
- L-Ornithine, N5-[imino(methylthio)methyl]-, hydrochloride (1:2)
- CAS:
- 209589-59-3
- MF:
- C7H15N3O2S.2HCl
- MW:
- 278.2
- Mol File:
- 209589-59-3.mol
S-Methyl-L-thiocitrulline dihydrochloride Chemical Properties
- storage temp.
- Freezer (-20°C)
- solubility
- DMF: >14 mg/ml; DMSO: >20 mg/ml; Ethanol: >75 mg/ml; PBS pH 7.2: >25 mg/ml
- form
- White to off-white solid.
- color
- white to off-white
- Water Solubility
- water: 50mg/mL
S-Methyl-L-thiocitrulline dihydrochloride Usage And Synthesis
Chemical Properties
white to tan amorphous powder
Uses
S-Methyl-L thiocitrulline, Dihydrochloride is a potent inhibitor of NOS1 and NOS3.
Definition
ChEBI: S-methyl-L-Thiocitrulline (hydrochloride) is a L-alpha-amino acid.
Biological Activity
Cell permeable: yes', 'Primary Target
R at neuronal nitric oxide synthase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 300 nM for r at neuronal nitric oxide synthase
in vivo
S-MTC dihydrochloride (S-methyl-L-thiocitrulline) is a selective neuronal NOS-inhibitor. Following pretreatment with S-MTC dihydrochloride (i.c.v.), the HBO2-induced antinociception is significantly antagonized. In Experiment #2, different groups of mice are pretreated with naltrexone hydrochloride (NTX) (3.0 mg/kg, i.p.), L-NAME (1.0 μg/mouse, i.c.v.), S-MTC dihydrochloride (1.0 μg/mouse, i.c.v.) or N5-(1-iminoethyl)-L-ornithine (L-NIO) (3.0 mg/kg, s.c.) 15-30 min prior to HBO2 treatment. The antinociceptive effect assessed 90 min after HBO2 treatment is completely abolished by NTX and L-NAME, antagonized by two-thirds by S-MTC dihydrochloride and largely unaffected by L-NIO (F=25.57, p<0.0001)[2]. At a dose of 0.3 mg/kg, S-MTC dihydrochloride (SMTC) causes a rise in mean blood pressure (BP). At doses of 1.0, 3.0 and 10 mg/kg, S-MTC dihydrochloride causes falls in heart rate, rises in BP and vasoconstriction in all three vascular beds[3].
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