Basic information Safety Supplier Related

Amphomycin

Basic information Safety Supplier Related

Amphomycin Basic information

Product Name:
Amphomycin
Synonyms:
  • Amphomycin
  • Nsc267431
CAS:
1402-82-0
MF:
C58H91N13O20
MW:
1290.43
EINECS:
215-760-0
Mol File:
1402-82-0.mol
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Amphomycin Chemical Properties

alpha 
D25 +7.5° (c = 1 at pH 6)
Boiling point:
854.06°C (rough estimate)
Density 
1.0985 (rough estimate)
refractive index 
1.6700 (estimate)
color 
Crystals
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Safety Information

Toxicity
LD50 orl-mus: 500 mg/kg 85GDA2 4(1),317,80
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Amphomycin Usage And Synthesis

Originator

Amphocortrin CR,Warner Lambert,US,1963

Uses

Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is active against Gram positive bacteria, inhibiting peptidoglycan synthesis and blocking cell wall development. Amphomycin is closely related to a number of “lost” antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.

Manufacturing Process

The process for producing amphomycin comprises cultivating a strain of Streptomyces canus in an aqueous, nutrient-containing carbohydrate solution under submerged aerobic conditions until substantial antibacterial activity is imparted to the solution and then recovering the so-produced amphomycin from the fermentation broth.
The process of decolorizing solutions of amphomycin then involves treatment with activated charcoal, followed by the steps of (1) extracting the antibiotic into a water-immiscible organic solvent under strongly acid conditions or precipitating the amphomycin from aqueous solution by adjusting the pH to a point within the range of pH 3.0 to 4.0, (2) removing impurities from strongly acid, aqueous solution of amphomycin by extraction of the impurities with methyl isobutyl ketone and amyl acetate, (3) extracting the amphomycin from a strongly acid solution in butanol by the use of water having a pH higher than 4, (4) extracting the amphomycin from solution in water-immiscible organic solvent into water whose pH is greater than 6.0, (5) precipitating amphomycin from solution by formation of insoluble derivatives of the basic function, and (6) precipitating amphomycin from solution by formation of insoluble derivates of the acidic function.
The amphomycin is then converted to the calcium salt with calcium hydroxide.

Therapeutic Function

Antibiotic

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Induces hemolysis. Active against gram-positive bacteria.Suggested as a topical agent for animal and plantinfections. When heated to decomposition it emits acridsmoke and

Amphomycin Supplier

ChemStrong Scientific Co.,Ltd
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0755-66853366-
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Novachemistry
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+44 (0)208 191 7890
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info@novachemistry.com
Shenzhen Polymeri Biochemical Technology Co., Ltd.
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400-002-6226
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sales@biochemall.cn
BOC Sciences
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16314854226
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inquiry@bocsci.com
Career Henan Chemica Co
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0371-86658258
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Laboratory@coreychem.com