ChemicalBook > CAS DataBase List > (S)-(-)-2-Azetidinecarboxylic acid

(S)-(-)-2-Azetidinecarboxylic acid

Product Name
(S)-(-)-2-Azetidinecarboxylic acid
CAS No.
2133-34-8
Chemical Name
(S)-(-)-2-Azetidinecarboxylic acid
Synonyms
(S)-AZETIDINE-2-CARBOXYLIC ACID;H-AZE-OH;L-AZETIDINE-2-CARBOXYLIC ACID;L-H-Aze-OH;H-AZE(2)-OH;(S)-(-)-2-Azetidinec;N,3-Methylene-L-alanine;L-AZETIDINECARBOXYLIC ACID;l-2-azetidinecarboxylicaci;azetidyl-2-carboxylic acid
CBNumber
CB0128117
Molecular Formula
C4H7NO2
Formula Weight
101.1
MOL File
2133-34-8.mol
More
Less

(S)-(-)-2-Azetidinecarboxylic acid Property

Melting point:
~215 °C (dec.)
alpha 
-125 º (c=1, water 25 ºC)
Boiling point:
189.47°C (rough estimate)
Density 
1.2245 (rough estimate)
refractive index 
-122 ° (C=4, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
pka
2.35±0.20(Predicted)
form 
Crystalline Powder or Crystals
color 
White to light beige
Water Solubility 
5 g/100 mL
Merck 
14,908
BRN 
80678
InChIKey
IADUEWIQBXOCDZ-VKHMYHEASA-N
CAS DataBase Reference
2133-34-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
CM4310500
Hazard Note 
Irritant
HS Code 
29339900
Hazardous Substances Data
2133-34-8(Hazardous Substances Data)
Toxicity
LD50 scu-mus: 1000 mg/kg 85GDA2 8(1),101,82
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0760
Product name
L-Azetidine-2-carboxylic acid
Purity
≥99%
Packaging
50mg
Price
$85.9
Updated
2024/03/01
Sigma-Aldrich
Product number
A0760
Product name
L-Azetidine-2-carboxylic acid
Purity
≥99%
Packaging
1g
Price
$711
Updated
2024/03/01
TCI Chemical
Product number
A1043
Product name
L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline]
Purity
>98.0%(T)
Packaging
1g
Price
$279
Updated
2024/03/01
TCI Chemical
Product number
A1043
Product name
L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline]
Purity
>98.0%(T)
Packaging
100mg
Price
$49
Updated
2024/03/01
Alfa Aesar
Product number
L09668
Product name
(S)-(-)-Azetidine-2-carboxylic acid, 98%
Packaging
250mg
Price
$120.65
Updated
2024/03/01
More
Less

(S)-(-)-2-Azetidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Specific proline antagonist. Used in synthesis of abnormally high molecular weight polypeptides.

Uses

L-Azetidine-2-carboxylic acid has been used as a:

  • collagen synthesis inhibitor
  • protein folding antagonist
  • as a standard in liquid chromatography-mass spectrometry

Uses

(S)-(-)-2-Azetidinecarboxylic acid is a four-membered ring analog of L-Proline, It is a useful intermediate in the synthesis of polypeptides,Used in synthesis of abnormally high molecular weight polypeptides.

Definition

ChEBI: The (S)-enantiomer of azetidine-2-carboxylic acid.

General Description

L-Azetidine-2-carboxylic acid is a non-protein amino acid and teratogenic agent. It is toxic in nature.

Biochem/physiol Actions

Azetidine-2-carboxylic acid (AZC) triggers protein aggregation or upregulates the expression of an aggregation-prone mutant protein, upon interference with nascent protein folding.

Safety Profile

Moderately toxic by subcutaneousroute. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.

(S)-(-)-2-Azetidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide Acetonitrile 2-Bromoethanol Potassium carbonate Palladium L-1-Phenylethylamine Tetrahydrofuran Diethyl ether Ammonium chloride Ethyl acetate Hydrochloric acid Bromoacetonitrile Sodium bicarbonate Dichloromethane Methanol Dimethyl sulfoxide Thionyl chloride PETROLEUM ETHER

Preparation Products

More
Less

(S)-(-)-2-Azetidinecarboxylic acid Suppliers

Americas 1 Belgium 1 Canada 1 China 225 Europe 3 Germany 3 India 9 Japan 8 Slovakia 1 South Korea 1 Sweden 2 Switzerland 7 The Netherlands 1 United Kingdom 19 United States 54 USA 1 Global 337
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
18478
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Bachem Americas, Inc.
Tel
--
Fax
--
Email
sales.us@bachem.com
Country
United States
ProdList
161
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Kaneka America LLC (part of Kaneka Corporation Japan)
Tel
--
Fax
--
Email
alexis.mercado@kaneka.com
Country
United States
ProdList
51
Advantage
58
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Chem-Impex International, Inc. (CII)
Tel
--
Fax
--
Email
Customer@chemimpex.com
Country
United States
ProdList
893
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
AAPPTEC
Tel
--
Fax
--
Email
info@aapptec.com
Country
United States
ProdList
533
Advantage
0
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Active Biopharma Corp
Tel
--
Fax
--
Email
support@activebiopharma.com
Country
United States
ProdList
82
Advantage
0
Gainbiotech, LLC
Tel
--
Fax
--
Email
sales@gainbiotech.com
Country
United States
ProdList
616
Advantage
0
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
More
Less

View Lastest Price from (S)-(-)-2-Azetidinecarboxylic acid manufacturers

Honest Joy Holdings Limited
Product
(S)-L-Azetidine-2-carboxylic acid 2133-34-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
100 tons
Release date
2022-01-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-(-)-2-Azetidinecarboxylic acid 2133-34-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline] 2133-34-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

2133-34-8, (S)-(-)-2-Azetidinecarboxylic acidRelated Search:

Citric acid Calconcarboxylic acid Albuterol sulfate 2,5-PYRIDINEDICARBOXYLIC ACID Cyclobutylamine DOBUTAMINE ISOBUTANE TRIMETHYLENE OXIDE AMIKACIN Quinolinic acid Azetidine n-Butane Salbutamol 1-Chloro-2-methylpropane 3-Azetidinecarboxylic acid Ascoric Acid (S)-BENZYL 2-AZETIDINONE-4-CARBOXYLATE 1-Boc-L-azetidine-2-carboxylic acid

  • (S)-(-)-2-AZETIDINECARBOXYLIC ACID
  • (S)-2-AZETIDINE CARBOXYLIC ACID
  • (S)-(-)-AZETIDINE-2-CARBOXYLIC ACID
  • (S)-AZETIDINE-2-CARBOXYLIC ACID
  • (S)-L-2-AZETIDINE CARBOXYLIC ACID
  • (2S)-(-)-AZETIDINE-2-CARBOXYLIC ACID
  • L-TRIMETHYLENEIMINE-2-CARBOXYLIC ACID
  • L-AZETIDINE-2-CARBOXYLIC ACID
  • L-AZETIDINECARBOXYLIC ACID
  • L-2-AZETIDINECARBOXYLIC ACID
  • H-AZE(2)-OH
  • H-AZE-OH
  • (S)-Azetidine-2-carboxylic acid, L-2-Azetidinecarboxylic acid, L-Azetidine-2-carboxylic acid
  • (2S)-2-Azetidinecarboxylic acid
  • N,3-Methylene-L-alanine
  • (s)-2-azetidinecarboxylicaci
  • 2-Azetidinecarboxylic acid, (2S)-
  • L-Azetidine-2-carboxylic acid ,98%
  • L-Azetidine-2-carboxylic acid ,99%
  • (S)-(-)-2-Azetidinec
  • (S)-(-) Azetidine-2-carbo...
  • (S)-L-Azetidine-2-carboxylic acid
  • (S) - (-) - 2- carboxy cyclobutylaMine
  • (S)-2-Azetidine-2-carboxylic acid
  • L-Azetidine-2-carboxylic acid≥ 97% (Assay)
  • acidel-azetidine-2-carboxylic
  • acidel-azetidine-2-carboxylic(french)
  • l-2-azetidinecarboxylicaci
  • l-azetidine-2-carboxylicaci
  • L-AZETIDINE-2-CARBOXYLIC ACID*CRYSTALLIN E
  • (S)-(-)-2-AZETIDINECARBOXYLIC ACID, 99+%
  • (S)-(-)-2-Azetidinecarboxylic
  • azetidyl-2-carboxylic acid
  • L-H-Aze-OH
  • L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline]
  • L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline]&gt
  • (S)-(-)-2-Azetidinecarboxylic acid ISO 9001：2015 REACH
  • (S)-Azetidine-2-carboxylic acid/(S)-2-Azetidine carboxylic acid/L-Azetidine-2-carboxylic acid
  • (S)-azetidine-2-carboxylicaci
  • (-)-Azetidinecarboxylic acid
  • (S)-Azetidine carboxylic acid
  • 2133-34-8
  • Chiral Building Blocks
  • Carboxylic Acids (Chiral)
  • Simple 4-Membered Ring Compounds
  • Azetidines
  • Cell Biology
  • Angiogenesis Regulators
  • BioChemical
  • Cell Signaling and Neuroscience
  • Extracellular Matrix
  • Cytoskeleton and Extracellular Matrix
  • Others
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Amino Acids 13C, 2H, 15N
  • Carboxylic Acids (Chiral)