ChemicalBook > CAS DataBase List > 2-Bromo-5-fluoroaniline

2-Bromo-5-fluoroaniline

Product Name
2-Bromo-5-fluoroaniline
CAS No.
1003-99-2
Chemical Name
2-Bromo-5-fluoroaniline
Synonyms
2-Bromo-5-fluoro-phenylamine;2-Bromo-5-fluoroanil;Vandetanib Impurity 3;2-BROMO-5-FLUOROANILINE;13-Cyanophenyl&isocyanate;2-Bromo-5-fluoroaniline98%;2-Bromo-5-fluoroaniline >2-Bromo-5-fluoroaniline 98%;2-BROMO-5-FLUOROBENZENAMINE;2-Bromo-5-fluoroaniline,99%
CBNumber
CB0184425
Molecular Formula
C6H5BrFN
Formula Weight
190.01
MOL File
1003-99-2.mol
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2-Bromo-5-fluoroaniline Property

Melting point:
43-47 °C (lit.)
Boiling point:
154 °C / 23mmHg
Density 
1.694±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
1.52±0.10(Predicted)
color 
White to Light yellow to Dark green
InChI
InChI=1S/C6H5BrFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
InChIKey
FWTXFEKVHSFTDQ-UHFFFAOYSA-N
SMILES
C1(N)=CC(F)=CC=C1Br
CAS DataBase Reference
1003-99-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN2811
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
528900
Product name
2-Bromo-5-fluoroaniline
Purity
97%
Packaging
25g
Price
$50.4
Updated
2023/01/07
TCI Chemical
Product number
B2163
Product name
2-Bromo-5-fluoroaniline
Purity
>98.0%(GC)
Packaging
5g
Price
$56
Updated
2024/03/01
TCI Chemical
Product number
B2163
Product name
2-Bromo-5-fluoroaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$166
Updated
2024/03/01
Alfa Aesar
Product number
B24901
Product name
2-Bromo-5-fluoroaniline, 98%
Packaging
5g
Price
$51.65
Updated
2024/03/01
Alfa Aesar
Product number
B24901
Product name
2-Bromo-5-fluoroaniline, 98%
Packaging
25g
Price
$190.65
Updated
2024/03/01
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2-Bromo-5-fluoroaniline Chemical Properties,Usage,Production

Description

2-bromo-5-fluoroaniline: a intermediate of antitumor drug.
2-bromo-5-fluoroaniline is the intermediate of antitumor drug Phortress, phortress is the benzothiazoles CYP1A1 antitumor drugs targeting by Univ Nottingham UK invention, solution becomes lipophilic compound 5F2O3(10 in the sensitive cells but Phortress enters), the latter is as potential aromatic hydrocarbon receptor (AhR) agonist, induce CYP1A1 to express, CYP1A1 metabolism through expressing produces and has high electrophilic active substance again, finally causes DNA damage and apoptosis. The method that, at present, synthetic 2-bromo-5-fluoronitrobenzene prepares 2-bromo-5-fluoroaniline is divided into two large classes:
The one: adopt a chemical reduction method, utilizing the chemical reducing agent reductase 2-bromo-5-fluoronitrobenzenes such as protochloride glass putty, iron powder, vat powder, hydrazine, and sodium borohydride (potassium), which is 2-bromo-5-fluoroaniline.
The 2nd: adopt hydro-reduction. What we do more often both at home and abroad at present is chloride or the catalytic hydrogenation of fluorine-containing arylamine, and the brominated less report of arylamine hydrogenation mainly is easily by hydrogenolysis because of bromine.

Chemical Properties

Yellow to brown crystalline powder

Uses

2-Bromo-5-fluoroaniline may be used to synthesize:

  • orthobromothiobenzanilide of 5-fluoronitrobenzothiazole
  • 2-bromo-5-fluorobenzo[14C]nitrile
  • [3-14C]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
  • 2-bromo-5-fluoro-phenyl)-(2-methoxy-6-pentadecyl-benzyl)amine

Synthesis

A preparation method of 2-Bromo-5-fluoroaniline is as follows: methanol, 2-bromo-5-fluoronitrobenzene, W-4 type Raney nickel and bromine inhibitor are put into a hydrogenation kettle to carry out hydrogenation reaction. After the reaction is completed, the reaction solution is filtered under nitrogen protection. The filtered filtrate is then distilled under reduced pressure to remove methanol, and n-hexane is added. Then, the product is washed with process water, and after washing, the product is allowed to stand and separate. Then, the organic phase is cooled and crystallized, an off-white to brownish-yellow solid is precipitated, and a wet product is obtained by suction filtration. The wet product is dried to obtain the finished product 2-Bromo-5-fluoroaniline.

2-Bromo-5-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-fluoroaniline Suppliers

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View Lastest Price from 2-Bromo-5-fluoroaniline manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
2-Bromo-5-fluoroaniline 1003-99-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-18
Suzhou Nordica Biopharma CO.,LTD
Product
2-bromo-5-fluoroaniline 1003-99-2
Price
US $0.00-0.00/kg
Min. Order
0.005kg
Purity
0.98
Supply Ability
2 tons
Release date
2024-11-15
Hebei Weibang Biotechnology Co., Ltd
Product
2-Bromo-5-fluoroaniline 1003-99-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-11

1003-99-2, 2-Bromo-5-fluoroanilineRelated Search:

4-Fluoroaniline 2-Fluoroaniline 4-(Trifluoromethoxy)aniline 2-Bromoaniline 2-Aminobenzotrifluoride 3-Fluoroaniline Diphenylamine Ethyl bromodifluoroacetate Bromine 2,4,5-TRIFLUORO-6-BROMOANILINE 2-AMINO-3,5-DIBROMO-6-FLUOROBENZOIC ACID 2-Bromo-4,5-difluoronitrobenzene 1-BROMO-4-FLUORO-2-NITROBENZENE 3-Fluoro-4-broMoaniline 5-BROMO-2-FLUOROANILINE 2-BROMO-6-FLUOROANILINE 3-BROMO-4-FLUOROANILINE 2-BROMO-4,5,6-TRIFLUOROANILINE

  • 2-BROMO-5-FLUOROBENZENAMINE
  • 2-BROMO-5-FLUOROANILINE
  • 2-Bromo-5-fluoro-phenylamine
  • 2-Bromo-5-fluoroaniline 98%
  • 2-Bromo-5-fluoroaniline98%
  • 2-Bromo-5-fluoroaniline,99%
  • 2-Bromo-5-fluoroanil
  • BenzenaMine, 2-broMo-5-fluoro-
  • 2-BroMo-5-fluoroaniline, 99% 25GR
  • 2-broMo-5-fluoroaniline, 2-broMo-5-fluoro-phenylaMine, 2-broMo-5-fluorobenzeneaMine, 2-broMo-5-fluorobenzenaMine, 2-broMo-5-fluoro aniline, 2-broMo-5-fluoro-aniline, 2-BroM-5-fluor-anilin
  • 2-Bromo-5-fluoroaniline &gt
  • 2-Bromo-5-fluoroaniline ISO 9001：2015 REACH
  • 13-Cyanophenyl&isocyanate
  • Vandetanib Impurity 3
  • Nitazoxanide Impurity 4（SU 3327）
  • 1003-99-2
  • Nitrogen Compounds
  • Organic Building Blocks
  • C2 to C6
  • Amines
  • Building Blocks
  • amine| alkyl bromide| alkyl Fluorine
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • C6
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Nitrogen Compounds
  • Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Other Fluorinated Organic Building Blocks
  • Amines
  • C2 to C6
  • Nitrogen Compounds
  • Aniline
  • Anilines, Amides & Amines
  • Bromine Compounds
  • Fluorine Compounds
  • Pharmaceutical intermediate
  • bc0001