Z-VAD-FMK

ChemicalBook > CAS DataBase List > Z-VAD-FMK

Product Name: Z-VAD-FMK
CAS No.: 187389-52-2
Chemical Name: Z-VAD-FMK
Synonyms: CS-2005;CS-1507;Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I
CBNumber: CB0203438
Molecular Formula: C22H30FN3O7
Formula Weight: 467.49
MOL File: Mol file

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Z-VAD-FMK Property

Melting point:: >190°C (dec.)
Boiling point:: 732.4±60.0 °C(Predicted)
Density: 1.214±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 396.7℃
storage temp.: -20°C
solubility: DMSO: 20 mg/mL
form: powder
pka: 11.05±0.46(Predicted)
color: white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey: MIFGOLAMNLSLGH-QOKNQOGYSA-N
SMILES: C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(OC)=O)C(=O)CF
CAS DataBase Reference: 187389-52-2

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V116
Product name: Z-VAD-FMK
Purity: solid
Packaging: 2mg
Price: $814
Updated: 2024/03/01

Sigma-Aldrich

Product number: 627610
Product name: Caspase Inhibitor I
Packaging: 1mg
Price: $318
Updated: 2024/03/01

Sigma-Aldrich

Product number: SAB2501669
Product name: Anti-CASP3 antibody produced in goat
Purity: affinity isolated antibody, buffered aqueous solution
Packaging: 100μg
Price: $568
Updated: 2024/03/01

Sigma-Aldrich

Product number: 627610
Product name: Caspase Inhibitor I
Packaging: 5mg
Price: $662
Updated: 2024/03/01

Cayman Chemical

Product number: 14463
Product name: Z-VAD(OMe)-FMK
Purity: ≥95%
Packaging: 1mg
Price: $100
Updated: 2024/03/01

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Z-VAD-FMK Chemical Properties,Usage,Production

Description

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

Uses

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

Uses

Z-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.

Definition

ChEBI: Z-Val-Ala-Asp(OMe)-CH2F is a tripeptide consisting of Z-Val-Ala-Asp(OMe) in which the C-terminal OH group has been replaced by a fluoromethyl group. An irreversible pan-caspase inhibitor. It has a role as an apoptosis inhibitor and a protease inhibitor. It is a carbamate ester, a tripeptide and an organofluorine compound.

General Description

A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Biochem/physiol Actions

Cell permeable: yes

Enzyme inhibitor

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

storage

-20°C

References

1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD-FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21 2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5 3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608

Z-VAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Z-VAD-FMK manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Z-VAD-FMK 187389-52-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-08

Career Henan Chemical Co

Product: Z-VAD-FMK 187389-52-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-21

187389-52-2, Z-VAD-FMKRelated Search:

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Z-VAD-FLUOROMETHYLKETONE

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Anti-CASP3 antibody produced in goat

caspase 3, apoptosis-related cysteine peptidase

caspase 3, apoptosis-related cysteine protease

HGNC:1504

Z-VAD-FMK, >=98%

Z-VAD-FMK, 98%, an irreversible pan-caspase inhibitor

Z-VAD(OME)-FMK;Z-VAL-ALA-ASP(OME)-FMK

Z-VAD(OME)-FMK

Z-VAL-ALA-ASP-FLUOROMETHYLKETONE

Z-VAL-ALA-ASP-FMK

Z-VAL-ALA-ASP(OCH3)-FLUOROMETHYLKETONE

Z-VAL-ALA-ASP(OME)-CH2F

Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

Z-VAL-ALA-ASP-(OME)-FMK

Z-VAL-ALA-DL-ASP-FLUOROMETHYLKETONE

Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE

Z-VA(OME)D-FMK

N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

BENZYLOXYCARBONYL-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

CARBOBENZOXY-VALYL-ALANYL-ASPARTYL-[O-METHYL]-FLUOROMETHYLKETONE

CASPASE-1, INHIBITOR

CASPASE-1 INHIBITOR VI (FLUOROMETHYLKETONE)

CASPASE INHIBITOR I

CASPASE INHIBITOR VI

Z-VAD-FMK, Non-methylated

PN: WO2005039629 PAGE: 18 claimed protein

Z-VAD-FMK (Cell perMeable)

3: PN: WO0158526 SEQID: 3 claimed sequence

N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide

Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONEZ-Val-Ala-DL-Asp-fluoroMethylketone

CS-2005

CS-1507

Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK)

Methyl (S)-3-[(S)-2-[(S)-2-(Cbz-amino)-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate

(5S,8S,11S)-Methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate

Z-VAD-FMK USP/EP/BP

Caspase 3/7 Activity Assay Kit

Methyl (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate

Inhibitor,ZVAD(OMe)FMK,inhibit,Caspase,Z VAD(OMe) FMK

Z-Val-Ala-Dl-Asp(Ome)-FMK

187389-52-2

67465-36-3

C22H30FN3O7

C21H28N3O7F

C22H30N3O7F

BioChemical

Apoptosis and Cell Cycle

Cell Biology

Cell Signaling and Neuroscience