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Z-VAD-FMK

Product Name
Z-VAD-FMK
CAS No.
187389-52-2
Chemical Name
Z-VAD-FMK
Synonyms
CS-2005;CS-1507;Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I
CBNumber
CB0203438
Molecular Formula
C22H30FN3O7
Formula Weight
467.49
MOL File
Mol file
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Z-VAD-FMK Property

Boiling point:
732.4±60.0 °C(Predicted)
Density 
1.214±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
396.7℃
storage temp. 
−20°C
solubility 
DMSO: 20 mg/mL
pka
11.05±0.46(Predicted)
form 
powder
color 
white
InChIKey
MIFGOLAMNLSLGH-QOKNQOGYSA-N
CAS DataBase Reference
187389-52-2
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
627610
Product name
Caspase Inhibitor I
Packaging
1mg
Price
$249
Updated
2020/08/18
Sigma-Aldrich
Product number
SAB2501669
Product name
Anti-CASP3 antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100 μg
Price
$460
Updated
2021/03/22
Sigma-Aldrich
Product number
627610
Product name
Caspase Inhibitor I
Packaging
5mg
Price
$521
Updated
2020/08/18
Sigma-Aldrich
Product number
V116
Product name
Z-VAD-FMK
Purity
solid
Packaging
2 mg
Price
$682
Updated
2021/03/22
Cayman Chemical
Product number
14463
Product name
Z-VAD(OMe)-FMK
Purity
≥95%
Packaging
5mg
Price
$421
Updated
2021/03/22
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Z-VAD-FMK Chemical Properties,Usage,Production

Uses

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Enzyme inhibitor

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

Z-VAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Z-VAD-FMK manufacturers

career henan chemical co
Product
Z-VAD-FMK 187389-52-2
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

187389-52-2, Z-VAD-FMKRelated Search:


  • Z-VADC(OME)-FMK
  • methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-phenylmethoxycarbonylamino-butanoyl]amino]propanoyl]amino]-4-oxo-pentanoate
  • N-BENZYLOXYCARBONYL-VAL-ALA-ASP FLUOROMETHYL KETONE
  • Z-VAD-FLUOROMETHYLKETONE
  • Z-VAD-FMK
  • Z-VAD-FMK, METHYL ESTER
  • Z-VAD(OME)-FLUOROMETHYLKETONE
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-
  • N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide z-vad -fmk
  • Anti-CASP3 antibody produced in goat
  • caspase 3, apoptosis-related cysteine peptidase
  • caspase 3, apoptosis-related cysteine protease
  • HGNC:1504
  • Z-VAD-FMK, >=98%
  • Z-VAD-FMK, 98%, an irreversible pan-caspase inhibitor
  • Z-VAD(OME)-FMK;Z-VAL-ALA-ASP(OME)-FMK
  • Z-VAD(OME)-FMK
  • Z-VAL-ALA-ASP-FLUOROMETHYLKETONE
  • Z-VAL-ALA-ASP-FMK
  • Z-VAL-ALA-ASP(OCH3)-FLUOROMETHYLKETONE
  • Z-VAL-ALA-ASP(OME)-CH2F
  • Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
  • Z-VAL-ALA-ASP-(OME)-FMK
  • Z-VAL-ALA-DL-ASP-FLUOROMETHYLKETONE
  • Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE
  • Z-VA(OME)D-FMK
  • N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
  • BENZYLOXYCARBONYL-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
  • CARBOBENZOXY-VALYL-ALANYL-ASPARTYL-[O-METHYL]-FLUOROMETHYLKETONE
  • CASPASE-1, INHIBITOR
  • CASPASE-1 INHIBITOR VI (FLUOROMETHYLKETONE)
  • CASPASE INHIBITOR I
  • CASPASE INHIBITOR VI
  • Z-VAD-FMK, Non-methylated
  • PN: WO2005039629 PAGE: 18 claimed protein
  • Z-VAD-FMK (Cell perMeable)
  • 3: PN: WO0158526 SEQID: 3 claimed sequence
  • N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide
  • Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONEZ-Val-Ala-DL-Asp-fluoroMethylketone
  • CS-2005
  • CS-1507
  • Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK)
  • Methyl (S)-3-[(S)-2-[(S)-2-(Cbz-amino)-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate
  • (5S,8S,11S)-Methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate
  • Z-VAD-FMK USP/EP/BP
  • 187389-52-2
  • C22H30FN3O7
  • C21H28N3O7F
  • C22H30N3O7F
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Caspases
  • Caspase 3
  • Inhibitors
  • Inhibitors
  • Caspases/Apoptosis