1,1'-Carbonyldiimidazole

Product Name: 1,1'-Carbonyldiimidazole
CAS No.: 530-62-1
Chemical Name: 1,1'-Carbonyldiimidazole
Synonyms: CDI;CARBONYLDIIMIDAZOLE;1,1'-CARBONYLDIIMIDAZOLE (CDI);DI(1H-IMIDAZOL-1-YL)METHANONE;N,N-CARBONYLDIIMIDAZOLE;Diimidazolyl ketone;1,1-CARBONYL DIIMIDAZOLE;5% Pd-BaSO4;CARBODIIMIDAZOLE;Di-imidazol-1-yl-methanone
CBNumber: CB0215374
Molecular Formula: C7H6N4O
Formula Weight: 162.15
MOL File: 530-62-1.mol

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1,1'-Carbonyldiimidazole Property

Melting point:: 117-122 °C(lit.)
Boiling point:: 288.83°C (rough estimate)
Density: 1.303 g/mL at 25 °C
vapor pressure: 0.006-0.012Pa at 20-25℃
refractive index: n20/D1.434
storage temp.: 2-8°C
solubility: Soluble in dimethylformamide.
pka: 2.90±0.10(Predicted)
form: Crystalline Powder
color: White to light cream
PH Range: 7.7 at 50 g/l
PH: 7.7 (50g/l, H2O, 20℃)
Water Solubility: Insoluble in water
Sensitive: Moisture Sensitive
Merck: 14,1819
BRN: 6826
Stability:: Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water.
InChIKey: PFKFTWBEEFSNDU-UHFFFAOYSA-N
CAS DataBase Reference: 530-62-1(CAS DataBase Reference)
EPA Substance Registry System: 1H-Imidazole, 1,1'-carbonylbis- (530-62-1)

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Safety

Hazard Codes: C,Xi,Xn
Risk Statements: 22-34-36/37/38-40-36/38
Safety Statements: 26-36/37/39-45-37/39-27-36/37
RIDADR: UN 3263 8/PG 2
WGK Germany: 2
F: 10-21
Hazard Note: Harmful/Corrosive/Moisture Sensitive
TSCA: T
HazardClass: 8
PackingGroup: III
HS Code: 29332990
Toxicity: LD50 orally in Rabbit: 1071 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.02301
Product name: 1,1′-Carbonyldiimidazole
Purity: for synthesis
Packaging: 2G
Price: $32.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.51054
Product name: CDI
Purity: 1,1′-Carbonyldiimidazole Novabiochem?
Packaging: 25g
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02301
Product name: 1,1′-Carbonyldiimidazole
Purity: for synthesis
Packaging: 5G
Price: $34.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.51054
Product name: CDI
Purity: 1,1′-Carbonyldiimidazole Novabiochem?
Packaging: 100g
Price: $514
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02301
Product name: 1,1′-Carbonyldiimidazole
Purity: for synthesis
Packaging: 25G
Price: $124
Updated: 2024/03/01

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1,1'-Carbonyldiimidazole Chemical Properties,Usage,Production

Chemical Properties

The substance appears as a white to slightly pale-yellow crystalline powder with a melting point range of 115.5-116°C. It exhibits poor solubility in water, while displaying solubility in alcohol and ether.

Uses

CDI, also known as 1,1'-carbonyldiimidazole, is a commonly used peptide coupling reagent in the synthesis of peptides and nucleoside triphosphates. It usually contains approximately 10% imidazole and reacts rapidly with carboxylic acids to produce acyl imidazoles. Later, it readily reacts with amines to create amides. In addition, CDI is useful in converting alcohols and amines into a range of chemical compounds, including carbamates, esters, and ureas.

Application

Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate.

Preparation

1,1'-Carbonyldiimidazole has been prepared by the reaction of imidazole and phosgene in anhydrous benzene and anhydrous tetrahydrofuran. It has also been obtained by the reaction of 1-(trimethylsilyl)imidazole and phosgene in anhydrous benzene, but that method offers no advantages that justify the more extensive preparative effort required.
DOI: 10.15227/orgsyn.048.0044

General Description

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.

Purification Methods

Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]

Precautions

1,1'-Carbonyldiimidazole is incompatible with oxidizing agents and strong acids and should not be stored or handled near them. Store in a refrigerator, under inert gas and protected from moisture. This substance is heat sensitive and moisture sensitive.

1,1'-Carbonyldiimidazole Preparation Products And Raw materials

Raw materials

Imidazole

Preparation Products

2-(Boc-aminomethyl)-piperidine 3-oxo-3-phenyl-propanamide 5-(Pyridin-3-yl)-1H-pyrazole-3-carboxamide ,97% 3-Cyanomethylthiophene 4-AMINOMETHYL-BENZAMIDE 2,8-DICHLOROPYRIMIDO[5,4-D]PYRIMIDINE Progabide 2-AMINO-5-BROMOBENZAMIDE 2-Ethylpiperazine 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE Pazufloxacin 5-BROMOTHIOPHENE-2-CARBONITRILE N-Heptafluorobutyrylimidazole 4-(Boc-Aminomethyl)piperidine 8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE 2-chloro-5-cyanopyridine 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE 1-Boc-2-Methylpiperazine 3-(1H-INDOL-3-YL)-1-PROPANAMINE 1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE 5-BROMO-2-BENZOXAZOLINONE 97 isoglutamine 3-BROMOTHIOPHENE-2-CARBOXAMIDE 1-Boc-4-(aminomethyl)piperidine 2,3-diaminonaphthalene 4-N-BOC-Aminopiperidine 5-AMINO-3-PYRIDINECARBONITRILE 4-Cyanopiperidine 1,3-THIAZOLIDIN-2-ONE

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1,1'-Carbonyldiimidazole Suppliers

Americas 1 Australia 1 Belgium 4 Canada 4 China 773 Czech 1 Europe 7 France 6 Germany 22 India 124 Ireland 1 Italy 1 Japan 16 Poland 2 Russia 1 Slovakia 1 South Korea 3 Switzerland 4 The Netherlands 3 Ukraine 1 United Kingdom 28 United States 96 Global 1100

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View Lastest Price from 1,1'-Carbonyldiimidazole manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 1,1'-Carbonyldiimidazole 530-62-1
Price: US $1000.00-400.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-12

Jinan Finer Chemical Co., Ltd

Product: 1,1'-Carbonyldiimidazole 530-62-1
Price: US $5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200mt
Release date: 2022-02-24

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1,1'-Carbonyldiimidazole 530-62-1
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-28

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