Boc-NH-PEG2-CH2COOH
- Product Name
- Boc-NH-PEG2-CH2COOH
- CAS No.
- 108466-89-3
- Chemical Name
- Boc-NH-PEG2-CH2COOH
- Synonyms
- 2,2-DiMethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid;Boc-AEEA-OH;2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylaMino]ethoxy]ethoxy]acetic acid;Boc-O 2 Oc-OH;2-diMethyl-4-oxo-;BocNH-PEG2-CH2COOH;NHBoc-PEG2-CH2COOH;Boc-N-amido-PEG2-CH2CO2H;t-Boc-N-amido-PEG2-CH2CO2H;t-Boc-N-Amido-PEG2-CH2COOH
- CBNumber
- CB02639228
- Molecular Formula
- C11H21NO6
- Formula Weight
- 263.29
- MOL File
- 108466-89-3.mol
Boc-NH-PEG2-CH2COOH Property
- Boiling point:
- 425.7±30.0 °C(Predicted)
- Density
- 1.145±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 3.40±0.10(Predicted)
- form
- liquid
- color
- Yellow
- InChI
- InChI=1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)
- InChIKey
- OMBVJVWVXRNDSL-UHFFFAOYSA-N
- SMILES
- C(O)(=O)COCCOCCNC(=O)OC(C)(C)C
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 901577
- Product name
- t-Boc-N-amido-PEG2-CH2CO2H
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $34.4
- Updated
- 2023/06/20
- Product number
- B694050
- Product name
- 8-tert-Butyloxycarbonylamino-3,6-dioxaoctanoicAcid
- Packaging
- 2.5g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- PEG8080
- Product name
- Boc-O2Oc
- Packaging
- 25g
- Price
- $1350
- Updated
- 2021/12/16
- Product number
- 280209
- Product name
- Boc-AEEA
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- BIPG1825
- Product name
- t-Boc-N-amido-PEG2-CH2CO2H
- Packaging
- 5g
- Price
- $540
- Updated
- 2021/12/16
Boc-NH-PEG2-CH2COOH Chemical Properties,Usage,Production
Description
t-Boc-N-amido-PEG2-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
t-Boc-N-amido-PEG2-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG2-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Synthesis
To a stirred solution of 2-(2-(2-Aminoethoxy)ethoxy)acetic acid (5.0 g, 30.6 mmol) in 1,4-Dioxane (50 mL), Sodium carbonate (8.12 g, 76.5 mmol, dissolved in 10 mL water) and (Boc)2O (9.98 mL, 45.7 mmol) were added and stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. The reaction mass was partitioned between diethyl ether and water. Then, the aqueous layer was made acidic (pH = 3) by 3N HC1 solution and was extracted with DCM (2 x 200 mL). The organic layer was washed with water, and brine, dried over Na2504 and evaporated under reduced pressure to yield 50 g of pure Boc-NH-PEG2-CH2COOH (Yield:62.1 per cent).
Boc-NH-PEG2-CH2COOH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boc-NH-PEG2-CH2COOH manufacturers
- Product
- 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid 108466-89-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000 kgs
- Release date
- 2024-05-20
- Product
- 2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic acid 108466-89-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25