ChemicalBook > CAS DataBase List > 2-Hydroxymethylmorpholine

2-Hydroxymethylmorpholine

Product Name
2-Hydroxymethylmorpholine
CAS No.
103003-01-6
Chemical Name
2-Hydroxymethylmorpholine
Synonyms
2-MORPHOLINEMETHANOL;2-Morpholinylmethanol;MORPHOLIN-2-YL-METHANOL;-Hydroxymethylmorpholine;2-HYDROXYMETHYLMORPHOLINE;Morpholin-2-ylMethanol-HCl;2-HYDROXYMETHYLMORPHOLINE 95%
CBNumber
CB0264099
Molecular Formula
C5H11NO2
Formula Weight
117.15
MOL File
103003-01-6.mol
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2-Hydroxymethylmorpholine Property

Boiling point:
220.1±15.0 °C(Predicted)
Density 
1.045±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
14.36±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
H972975
Product name
2-Hydroxymethylmorpholine
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
X8636
Product name
2-Hydroxymethylmorpholine
Packaging
100mg
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
073626
Product name
Morpholin-2-ylmethanol
Purity
95+%
Packaging
250mg
Price
$163
Updated
2021/12/16
AK Scientific
Product number
X8636
Product name
2-Hydroxymethylmorpholine
Packaging
1g
Price
$320
Updated
2021/12/16
Matrix Scientific
Product number
073626
Product name
Morpholin-2-ylmethanol
Purity
95+%
Packaging
1g
Price
$395
Updated
2021/12/16
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2-Hydroxymethylmorpholine Chemical Properties,Usage,Production

Uses

2-Hydroxymethylmorpholine is used to study structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B.

Synthesis

189321-66-2

103003-01-6

The general procedure for the synthesis of 2-hydroxymethylmorpholine from 4-Boc-2-morpholinecarboxylic acid was as follows: to a solution of N-Boc-2-morpholinecarboxylic acid (2 g) in tetrahydrofuran (THF, 5 mL) was slowly added a borane-THF complex (1N, 10.38 eq.) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and continued stirring for 2 hours. Upon completion of the reaction, the reaction was quenched by careful addition of water (200 mL) and then extracted with dichloromethane (CH2Cl2). The organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 490 mg of the crude product (26% yield). Finally, the crude product was dissolved in 4N hydrochloric acid/dioxolane solution with stirring to give the amine salt of 2-hydroxymethylmorpholine.

References

[1] Patent: WO2004/33440, 2004, A1. Location in patent: Page 173

2-Hydroxymethylmorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Hydroxymethylmorpholine manufacturers

Career Henan Chemical Co
Product
2-Hydroxymethylmorpholine 103003-01-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-20

103003-01-6, 2-HydroxymethylmorpholineRelated Search:

2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Indeloxazine Indeloxazine hydrochloride Teniloxazine Nafoxadol Reboxetine mesylate viloxazine (S)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester,(S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE (R )-2-Hydroxymethylmorpholine 4-N-BOC-2-HYDROXYMETHYLMORPHOLINE (R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE,(R)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (R)-4-Boc-3-hydroxymethylmorpholine FMOC-COP 4-BOC-2-MORPHOLINECARBOXYLIC ACID 4-CBZ-2-HYDROXYMETHYLMORPHOLINE (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE (R)-3-Hydroxymethylmorpholine,3(R)-HYDROXYMETHYLMORPHOLINE HCL,,3(R)-HYDROXYMETHYLMORPHOLINE 3(S)-HYDROXYMETHYLMORPHOLINE,(S)-3-Hydroxymethylmorpholine

  • MORPHOLIN-2-YL-METHANOL
  • 2-HYDROXYMETHYLMORPHOLINE 95%
  • Morpholin-2-ylMethanol-HCl
  • 2-HYDROXYMETHYLMORPHOLINE
  • 2-MORPHOLINEMETHANOL
  • -Hydroxymethylmorpholine
  • 2-Morpholinylmethanol
  • 103003-01-6
  • pharmacetical