2-Hydroxymethylmorpholine
- Product Name
- 2-Hydroxymethylmorpholine
- CAS No.
- 103003-01-6
- Chemical Name
- 2-Hydroxymethylmorpholine
- Synonyms
- 2-MORPHOLINEMETHANOL;2-Morpholinylmethanol;MORPHOLIN-2-YL-METHANOL;-Hydroxymethylmorpholine;2-HYDROXYMETHYLMORPHOLINE;Morpholin-2-ylMethanol-HCl;2-HYDROXYMETHYLMORPHOLINE 95%
- CBNumber
- CB0264099
- Molecular Formula
- C5H11NO2
- Formula Weight
- 117.15
- MOL File
- 103003-01-6.mol
2-Hydroxymethylmorpholine Property
- Boiling point:
- 220.1±15.0 °C(Predicted)
- Density
- 1.045±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 14.36±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- H972975
- Product name
- 2-Hydroxymethylmorpholine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- X8636
- Product name
- 2-Hydroxymethylmorpholine
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 073626
- Product name
- Morpholin-2-ylmethanol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $163
- Updated
- 2021/12/16
- Product number
- X8636
- Product name
- 2-Hydroxymethylmorpholine
- Packaging
- 1g
- Price
- $320
- Updated
- 2021/12/16
- Product number
- 073626
- Product name
- Morpholin-2-ylmethanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $395
- Updated
- 2021/12/16
2-Hydroxymethylmorpholine Chemical Properties,Usage,Production
Uses
2-Hydroxymethylmorpholine is used to study structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B.
Synthesis
189321-66-2
103003-01-6
The general procedure for the synthesis of 2-hydroxymethylmorpholine from 4-Boc-2-morpholinecarboxylic acid was as follows: to a solution of N-Boc-2-morpholinecarboxylic acid (2 g) in tetrahydrofuran (THF, 5 mL) was slowly added a borane-THF complex (1N, 10.38 eq.) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and continued stirring for 2 hours. Upon completion of the reaction, the reaction was quenched by careful addition of water (200 mL) and then extracted with dichloromethane (CH2Cl2). The organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 490 mg of the crude product (26% yield). Finally, the crude product was dissolved in 4N hydrochloric acid/dioxolane solution with stirring to give the amine salt of 2-hydroxymethylmorpholine.
References
[1] Patent: WO2004/33440, 2004, A1. Location in patent: Page 173
2-Hydroxymethylmorpholine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxymethylmorpholine Suppliers
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
- 76
View Lastest Price from 2-Hydroxymethylmorpholine manufacturers
- Product
- 2-Hydroxymethylmorpholine 103003-01-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20