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4-Fluoro-2-methoxybenzonitrile

Product Name
4-Fluoro-2-methoxybenzonitrile
CAS No.
191014-55-8
Chemical Name
4-Fluoro-2-methoxybenzonitrile
Synonyms
BUTTPARK 80\07-22;4-Fluoro-o-anisonitrile;4-Fluoro-2-methoxybenzonitril;4-FLUORO-2-METHOXYBENZONITRILE;Benzonitrile, 4-fluoro-2-methoxy-;Benzonitrile, 4-fluoro-2-methoxy- (9CI);4-Fluoro-o-anisonitrile, 2-Cyano-5-fluoroanisole
CBNumber
CB0298137
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
191014-55-8.mol
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4-Fluoro-2-methoxybenzonitrile Property

Melting point:
75 °C
Boiling point:
239.2±20.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
crystalline solid
color 
White to off-white
CAS DataBase Reference
191014-55-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
23-36/37/39
RIDADR 
3276
Hazard Note 
Irritant
HazardClass 
6.1
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
F599358
Product name
4-Fluoro-2-methoxybenzonitrile
Packaging
500mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-3-X1
Product name
4-Fluoro-2-methoxybenzonitrile
Packaging
25g
Price
$232
Updated
2021/12/16
AK Scientific
Product number
X2776
Product name
4-Fluoro-2-methoxybenzonitrile
Packaging
25g
Price
$237
Updated
2021/12/16
Matrix Scientific
Product number
131684
Product name
4-Fluoro-2-methoxybenzonitrile
Purity
97%
Packaging
25g
Price
$468
Updated
2021/12/16
AK Scientific
Product number
X2776
Product name
4-Fluoro-2-methoxybenzonitrile
Packaging
100g
Price
$571
Updated
2021/12/16
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4-Fluoro-2-methoxybenzonitrile Chemical Properties,Usage,Production

Chemical Properties

off-white crytalline

Synthesis

450-88-4

544-92-3

191014-55-8

General procedure for the synthesis of 2-methoxy-4-fluorobenzonitrile from 2-bromo-5-fluoroanisole and cuprous cyanide: to a solution of N-methylpyrrolidone (100 mL, Sure Seal; Aldrich) containing 1-bromo-4-fluoro-2-methoxybenzene (9.0 g) was added cuprous cyanide (6.6 g, 73.7 mmol, 1.8 equiv. Aldrich). The reaction mixture was stirred at 180 °C for 5.5 h in an anhydrous nitrogen atmosphere. After completion of the reaction, it was cooled to room temperature, a 14% aqueous ammonia solution (330 mL) was added, and stirring was continued at room temperature for 45 min. The reaction mixture was extracted with ether (100 mL x 3), and the organic phases were combined, washed sequentially with dilute ammonia, dilute hydrochloric acid and brine, and then dried with anhydrous magnesium sulfate, and concentrated to give 2-methoxy-4-fluorobenzonitrile (5.2 g, 85% yield in two steps). The product was a white solid with the following 1H NMR (CDCl3,500MHz) data: δ 3.91 (3H, s, OMe), 6.69 (1H, dd, J = 2.3Hz, J = 10.5Hz, Ar-H), 6.72 (1H, dt, J = 2.5Hz, J = 8.0Hz, Ar-H), 7.55 (1H, dd, J = 6.5 Hz, J = 8.5 Hz, Ar-H); 13C NMR (CDCl3,125.8 Hz) data as follows: δ 56.49, 98.16, 100.06, 100.27, 108.31, 108.50, 115.83, 135.37, 135.46, 163.25, 163.34, 165.47, 167.50. 167.50. analytical samples were obtained by ether milling. Calculated values for elemental analysis (C8H6FNO): C, 63.57; H, 4.00; N, 9.26; measured values: C, 63.36; H, 3.91; N, 9.16.

References

[1] Patent: US2005/267105, 2005, A1. Location in patent: Page/Page column 67
[2] Patent: EP1510516, 2005, A1. Location in patent: Page/Page column 88
[3] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 32-33
[4] Patent: US2007/129379, 2007, A1. Location in patent: Page/Page column 26
[5] Patent: WO2007/64316, 2007, A1. Location in patent: Page/Page column 152

4-Fluoro-2-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoro-2-methoxybenzonitrile Suppliers

China 114 Europe 1 Germany 2 India 3 Italy 1 United Kingdom 16 United States 17 Global 154
HBCChem, Inc.
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View Lastest Price from 4-Fluoro-2-methoxybenzonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Fluoro-2-methoxybenzonitrile 191014-55-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-06
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Fluoro-2-methoxybenzonitrile 191014-55-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2025-03-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Fluoro-2-methoxybenzonitrile 191014-55-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

191014-55-8, 4-Fluoro-2-methoxybenzonitrileRelated Search:

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  • 4-FLUORO-2-METHOXYBENZONITRILE
  • BUTTPARK 80\07-22
  • 4-Fluoro-2-methoxybenzonitril
  • Benzonitrile, 4-fluoro-2-methoxy- (9CI)
  • 4-Fluoro-o-anisonitrile, 2-Cyano-5-fluoroanisole
  • Benzonitrile, 4-fluoro-2-methoxy-
  • 4-Fluoro-o-anisonitrile
  • 191014-55-8
  • Fluorine series
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Fluorine Compounds
  • Nitriles
  • HALIDE
  • Aromatic Nitriles