trans-1,2-Cyclohexanedicarboxylic acid

Product Name: trans-1,2-Cyclohexanedicarboxylic acid
CAS No.: 2305-32-0
Chemical Name: trans-1,2-Cyclohexanedicarboxylic acid
Synonyms: TRANS-HEXAHYDRO-PHTHALIC ACID;TRANS-CYCLOHEXANE-1,2-DICARBOXYLIC ACID;trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid;Lura;trans-CycL;REMAINDER CIS;RSYY（Avanafil)-15;ohexane-1,2-dicarboxyL;Lurasidone InterMediate(1);1,2-cyclohexanedicarboxylic
CBNumber: CB0376262
Molecular Formula: C8H12O4
Formula Weight: 172.18
MOL File: 2305-32-0.mol

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trans-1,2-Cyclohexanedicarboxylic acid Property

Melting point:: 228-230 °C (lit.)
Boiling point:: 262.49°C (rough estimate)
Density: 1.2104 (rough estimate)
refractive index: 1.4450 (estimate)
storage temp.: Store below +30°C.
solubility: Acetone (Slightly), DMSO (Slightly)
form: Solid
pka: pK1:4.18;pK2: 5.93 (20°C)
color: White
Water Solubility: 2g/L(20 ºC)
BRN: 3200609
InChIKey: QSAWQNUELGIYBC-WDSKDSINSA-N
CAS DataBase Reference: 2305-32-0(CAS DataBase Reference)
NIST Chemistry Reference: 1,2-Cyclohexanedicarboxylic acid, trans-(2305-32-0)
EPA Substance Registry System: 1,2-Cyclohexanedicarboxylic acid, (1R,2R)-rel- (2305-32-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: GU9065000
TSCA: Yes
HS Code: 29172000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.41088
Product name: trans-Cyclohexane-1,2-dicarboxylic acid
Purity: for synthesis
Packaging: 5G
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: 147516
Product name: trans-1,2-Cyclohexanedicarboxylic acid
Purity: 95%
Packaging: 25g
Price: $311
Updated: 2023/01/07

TCI Chemical

Product number: C0474
Product name: trans-1,2-Cyclohexanedicarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $129
Updated: 2024/03/01

TCI Chemical

Product number: C0474
Product name: trans-1,2-Cyclohexanedicarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $1217
Updated: 2024/03/01

Alfa Aesar

Product number: L11288
Product name: trans-1,2-Cyclohexanedicarboxylic acid
Purity: 98%
Packaging: 5g
Price: $56.65
Updated: 2024/03/01

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trans-1,2-Cyclohexanedicarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

trans-1,2-cyclohexanedicarboxylic acid be used as organic intermediates.

Uses

trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.

Purification Methods

It is purified by recrystallisation from EtOH or H2O. It is formed by hydrolyzing the anhydride with water. The dimethyl ester has m 95-96o (from *C6H6/pet ether). [Abell J Org Chem 22 769 1957, Smith & Byrne J Am Chem Soc 72 4406 1950, Linstead et al. J Am Chem Soc 64 2093 1942, Beilstein 9 III 3812, 9 IV 2801.] The 1R,2R-(-)-trans-cyclohexane-1,2-acid [46022-05-3] has m 171-182o and [ ] D -20o (c 1, Me2CO). cis-Cyclohexane-1,2-dicarboxylic anhydride (cis-hexahydrophthalic anhydride) [85-42-7, 13149-00-3] M 154.2, m 32-34o, b 158o/17mm. It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]

trans-1,2-Cyclohexanedicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from trans-1,2-Cyclohexanedicarboxylic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price: US $1.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-06-15

Hebei Mojin Biotechnology Co., Ltd

Product: trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

2305-32-0, trans-1,2-Cyclohexanedicarboxylic acidRelated Search:

Potassium hydrogen phthalate Dimethyl phthalate CYCLOHEXANE-1,1-DICARBOXYLIC ACID Phthalic acid Bis(2-ethylhexyl) phthalate Isophthalic acid trans,trans-2,4-Undecadienal Cyclohexane (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione (1R,2R)-1,2-CYCLOHEXANEDIMETHANOL TRANS-CYCLOBUTANE-1,2-DICARBOXYLIC ACID Cyclobutane-1α,3β-dicarboxylic acid CIS/TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID MONOMETHYL ESTER 1,2,3,4,5,6-Cyclohexanehexacarboxylic acid TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID 1,2-CYCLOHEXANEDICARBOXYLIC ACID TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID

trans-Cyclohexane-1,2-dicarboxylic acid for synthesis

TRANS-HEXAHYDRO-PHTHALIC ACID

TRANS-CYCLOHEXANE-1,2-DICARBOXYLIC ACID

TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID

trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid

TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID, 95%, REMAINDER CIS

rel-(1R*)-1β*,2α*-Cyclohexanedicarboxylic acid

rel-(1R*,2R*)-1,2-Cyclohexanedicarboxylic acid

rel-Cyclohexane-1β*,2α*-dicarboxylic acid

trans-1,2-Cyclohexanedicarboxylic acid, remainder cis, 95%

TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI

Trans-1,2-cyclohexane carboxylic acid

1,2-cyclohexanedicarboxylic

1,2-Cyclohexanedicarboxylicacid, (1R,2R)-rel-

trans-1,2-Cyclohexanedicarboxylic acid ,98%

Lurasidone InterMediate(1)

Lura

REMAINDER CIS

trans-1,2-Cyclohexanedicarboxylic acid, reMainder cis TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI

<i>trans</i>-1,2-Cyclohexanedicarboxylic acid

trans-1,2-Cyclohexanedicarboxylic acid 95%

(1S,2S)-2-Carbamoyl-cyclohexanecarboxylic acid

trans-1,2-Cyclohexanedicarboxylic Acid &gt

ohexane-1,2-dicarboxyL

trans-CycL

rans-1,2-Cyclohexanedicarboxylicaci

Trans-1,2-Cyclohexanedicarboxylic acid(For export only)

Tans-1,2-Cyclohexanedicarboxylic acid

RSYY（Avanafil)-15

Trans racemic 1,2-cyclohexanedicarboxylic acid

2305-32-0

CARBOXYLIC ACID

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts