4-(Bromomethyl)tetrahydropyran
- Product Name
- 4-(Bromomethyl)tetrahydropyran
- CAS No.
- 125552-89-8
- Chemical Name
- 4-(Bromomethyl)tetrahydropyran
- Synonyms
- 4-(broMoMethyl)oxane;4-bromomethytetrahydropyran;4-(BroMoMethyl)tetrahydro...;4-BROMOMETHYLTETRAHYDROPYRAN;4-(Bromomethyl)tetrahydropyrane;4-Bromomethyltetrahydropyran, 96%;4-(Bromomethyl)tetrahydropyran ,97%;4-(BROMOMETHYL)-TETRAHYDRO-2H-PYRAN;2H-Pyran, 4-(broMoMethyl)tetrahydro-;Tetrahydro-2H-pyran-4-yl-MethylbroMide
- CBNumber
- CB0436966
- Molecular Formula
- C6H11BrO
- Formula Weight
- 179.05
- MOL File
- 125552-89-8.mol
4-(Bromomethyl)tetrahydropyran Property
- Boiling point:
- 88 °C
- Density
- 1.359±0.06 g/cm3(Predicted)
- refractive index
- 1.49
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- liquid
- color
- Light beige/brown
- InChI
- InChI=1S/C6H11BrO/c7-5-6-1-3-8-4-2-6/h6H,1-5H2
- InChIKey
- LMOOYAKLEOGKJR-UHFFFAOYSA-N
- SMILES
- C1OCCC(CBr)C1
- CAS DataBase Reference
- 125552-89-8(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 36/37/38-34-22
- Safety Statements
- 26-36/37/39-45-23
- RIDADR
- 3265
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B6596
- Product name
- 4-(Bromomethyl)tetrahydro-2H-pyran
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $146
- Updated
- 2025/07/31
- Product number
- B6596
- Product name
- 4-(Bromomethyl)tetrahydro-2H-pyran
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $438
- Updated
- 2025/07/31
- Product number
- B697768
- Product name
- 4-Bromomethyltetrahydropyran
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 037029
- Product name
- 4-(Bromomethyl)tetrahydropyran
- Purity
- 95%
- Packaging
- 250mg
- Price
- $14
- Updated
- 2021/12/16
- Product number
- P000132139
- Product name
- 4-(Bromomethyl)tetrahydropyran
- Purity
- 95%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
4-(Bromomethyl)tetrahydropyran Chemical Properties,Usage,Production
Chemical Properties
Viscous liquid
Uses
4-(Bromomethyl)tetrahydropyran is an important organic synthesis intermediate, widely used in the fields of medicine, pesticides and dyes. It can be used to synthesize a variety of biologically active compounds, such as antibacterial agents, anti-tumor drugs, nervous system drugs and fluorescent dyes. In addition, 4-(Bromomethyl)tetrahydropyran can also be used to synthesize organic pigments and functional materials.
Application
4-(Bromomethyl)tetrahydropyran can be used as an intermediate in the synthesis of compounds with antibacterial activity. For example, it can be used to introduce other functional groups through nucleophilic substitution reactions to construct molecules with antibacterial activity. Certain compounds containing tetrahydropyran rings have been studied for their potential to inhibit bacterial growth and reproduction.
Synthesis
To a solution of Tetrahydropyran-4-methanol and N-bromobutanimide (NBS) in DCM was added PPh3 at 0°C. The reaction mixture was stirred at room temperature for 1–2h. The resulting mixture was washed with water (20mL) and brine (3×20mL). The organic layer was concentrated and the residue was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2–5%) to give 4-(Bromomethyl)tetrahydropyran as a colorless oil.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 896 - 916
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 5512,5514
[3] Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 80
[4] Chem.Abstr., 1940, p. 4396
[5] Journal of the American Chemical Society, 1993, vol. 115, # 18, p. 8401 - 8408
4-(Bromomethyl)tetrahydropyran Preparation Products And Raw materials
Raw materials
Preparation Products
4-(Bromomethyl)tetrahydropyran Suppliers
- Tel
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- Fax
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- interchim@interchim.com
- Country
- France
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- 6302
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View Lastest Price from 4-(Bromomethyl)tetrahydropyran manufacturers
- Product
- 4-BroMoMethyltetrahydropyran 125552-89-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 4-(Bromomethyl) tetrahydropyran 125552-89-8
- Price
- US $1500.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-02
- Product
- 4-(Bromomethyl)tetrahydropyran 125552-89-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-10