ChemicalBook > CAS DataBase List > 5-Amino-2-chloropyridine

5-Amino-2-chloropyridine

Product Name
5-Amino-2-chloropyridine
CAS No.
5350-93-6
Chemical Name
5-Amino-2-chloropyridine
Synonyms
6-CHLOROPYRIDIN-3-AMINE;6-chloro-3-pyridinamine;Tobrasix;5-Amino-2-chL;TIMTEC-BB SBB004234;AMINO CHLOROPYRIDINE;5-Amino-2-chlorpyridin;2-Chloro-5-pyridinamine;5- BROMO-2-METHOXYPHENOL;2-CHLORO-5-AMINOPYRIDINE
CBNumber
CB0687779
Molecular Formula
C5H5ClN2
Formula Weight
128.56
MOL File
5350-93-6.mol
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5-Amino-2-chloropyridine Property

Melting point:
81-83 °C(lit.)
Boiling point:
205.39°C (rough estimate)
Density 
1.2417 (rough estimate)
refractive index 
1.5110 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
1.94±0.10(Predicted)
color 
White to Brown
BRN 
108891
InChI
InChI=1S/C5H5ClN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2
InChIKey
QAJYCQZQLVENRZ-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC=C1N
CAS DataBase Reference
5350-93-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
188778
Product name
5-Amino-2-chloropyridine
Purity
98%
Packaging
5g
Price
$75.5
Updated
2025/07/31
Sigma-Aldrich
Product number
188778
Product name
5-Amino-2-chloropyridine
Purity
98%
Packaging
1g
Price
$85
Updated
2023/06/20
TCI Chemical
Product number
A1155
Product name
5-Amino-2-chloropyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
A1155
Product name
5-Amino-2-chloropyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$98
Updated
2025/07/31
TRC
Product number
A603585
Product name
3-Amino-6-chloropyridine
Packaging
1g
Price
$130
Updated
2021/12/16
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5-Amino-2-chloropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brown crystalline powder

Uses

5-Amino-2-chloropyridine was used in the synthesis of [2H5]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine. It was used in identification and evaluation of molecularly imprinted polymers for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals.

Definition

ChEBI: 3-Amino-6-chloropyridine is an aminopyridine.

General Description

5-Amino-2-chloropyridine undergoes Suzuki-Miyaura coupling with sterically hindered 2,6-dimethylphenylboronic acid. It undergoes facile temperature dependent displacement of chloride by bromide via Sandmeyer reaction to yield 2,5-dibromopyridine.

Synthesis

4548-45-2

5350-93-6

General method: 2-chloro-5-nitropyridine (1 eq.), hexafluoroisopropanol (HFIP, 10 eq.) and iron powder (5 eq.) were added to the reaction tube and mixed. Subsequently, 2N aqueous hydrochloric acid solution was slowly added to the reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes and then neutralized with saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was extracted three times with saturated aqueous sodium bicarbonate solution and combined. The organic layers were subsequently washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford the target product 2-chloro-5-aminopyridine.

References

[1] Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 1, p. 51 - 54
[2] Organic Letters, 2009, vol. 11, # 6, p. 1345 - 1348
[3] ACS Catalysis, 2014, vol. 4, # 6, p. 1777 - 1782
[4] New Journal of Chemistry, 2015, vol. 39, # 11, p. 8498 - 8504
[5] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3646 - 3649

5-Amino-2-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID 2-Chloro-5-fluoropyridine 5-AMINOPYRIDINE-2-BORONIC ACID PINACOL ESTER 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
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5-Amino-2-chloropyridine Suppliers

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View Lastest Price from 5-Amino-2-chloropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Amino-2-chloropyridine 5350-93-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Amino-2-chloropyridine 5350-93-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100kg/month
Release date
2021-10-28
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Amino-2-chloropyridine 5350-93-6
Price
US $8.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28

5350-93-6, 5-Amino-2-chloropyridineRelated Search:

4-Dimethylaminopyridine ALTRENOGEST Clopidol 3-Aminophenol 2-Chloro-5-chloromethylpyridine Glycine 3-Aminopyridine 6-Aminocaproic acid 2-Chloro-5-nitropyridine 2-Chloro-3-cyanopyridine 2-Aminopyridine 2-Chloropyridine Tris(hydroxymethyl)aminomethane 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine 3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 6-Chloro-2-methyl-3-nitropyridine

  • 3-PYRIDINAMINE, 6-CHLORO-
  • 3-AMINO-6-CHLOROPYRIDINE
  • 6-CHLOROPYRIDIN-3-AMINE
  • 6-CHLORO-PYRIDIN-3-YLAMINE
  • 5-AMINO-2-CHLOROPYRIDINE
  • 2-CHLORO-5-AMINOPYRIDINE
  • TIMTEC-BB SBB004234
  • AMINO CHLOROPYRIDINE
  • 6-chloro-3-pyridinamine
  • 3-Pyridinamine,6-chloro-(9CI)
  • 5- BROMO-2-METHOXYPHENOL
  • 5-Amino-2-chloropyridine ,98%
  • 2-Chloro-5-pyridinamine
  • 2-Chloropyridine-5-amine
  • 3-Amino-6-chloropyridine,98%
  • 5-Amino-2-chL
  • 5-Amino-2-chloropyridine &gt
  • 6-Chloro-4-methyl-5-pyridinecarboxylic acid
  • 5-Amino-2-chloropyridine ISO 9001：2015 REACH
  • 5-Amino-2-chlorpyridin
  • Tobrasix
  • 5-Amino-2-chloropyridine, 95%
  • 5350-93-6
  • 5350-93-2
  • 5350-96-6
  • 226-322-3
  • Building Blocks
  • HETERO CHLORIDE
  • Pyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Halopyridines
  • Chloropyridines
  • Chloropyridines
  • Halopyridines
  • Boronic Acid
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines derivates
  • PYRIDINE
  • Amines
  • blocks
  • Pyridines
  • pyridine derivative
  • Pyridine Series
  • Amino-pyridine series
  • compounds of pyridine
  • bc0001