ChemicalBook > CAS DataBase List > 5-Fluoro-2-methylbenzoic acid

5-Fluoro-2-methylbenzoic acid

Product Name
5-Fluoro-2-methylbenzoic acid
CAS No.
33184-16-6
Chemical Name
5-Fluoro-2-methylbenzoic acid
Synonyms
5-fluoro-2-met;RARECHEM AL BO 0443;5-FLUORO-O-TOLUIC ACID;5-Fluoro-2-methylbenzoic;JVBLXLBINTYFPR-UHFFFAOYSA-N;2-METHYL-5-FLUOROBENZOIC ACID;5-FLUORO-2-METHYLBENZOIC ACID;5-Fluoro-2-methylbenzoicacid99%;5-Fluoro-2-methylbenzoicAcid>Benzoic acid, 5-fluoro-2-Methyl-
CBNumber
CB0753120
Molecular Formula
C8H7FO2
Formula Weight
154.14
MOL File
33184-16-6.mol
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5-Fluoro-2-methylbenzoic acid Property

Melting point:
130-132 °C (lit.)
Boiling point:
262.1±20.0 °C(Predicted)
Density 
1.258±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
3.53±0.25(Predicted)
form 
Crystalline Powder
color 
Beige to light gray
BRN 
2249813
InChI
InChI=1S/C8H7FO2/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,1H3,(H,10,11)
InChIKey
JVBLXLBINTYFPR-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(F)=CC=C1C
CAS DataBase Reference
33184-16-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
366625
Product name
5-Fluoro-2-methylbenzoic acid
Purity
99%
Packaging
1g
Price
$33.3
Updated
2023/06/20
TCI Chemical
Product number
F0844
Product name
5-Fluoro-2-methylbenzoic Acid
Purity
>98.0%(GC)
Packaging
5g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
F0844
Product name
5-Fluoro-2-methylbenzoic Acid
Purity
>98.0%(GC)
Packaging
25g
Price
$176
Updated
2025/07/31
TRC
Product number
F595260
Product name
5-Fluoro-2-methylbenzoic acid
Packaging
50g
Price
$1230
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0024056
Product name
5-FLUORO-2-METHYLBENZOIC ACID
Purity
95.00%
Packaging
100G
Price
$2639.18
Updated
2021/12/16
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5-Fluoro-2-methylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

5-Fluoro-2-methylbenzoic acid may be used in the preparation of:

  • 5-fluoro-3-hydroxy-2-methylbenzoic acid
  • 5-fluoro-2-methyl-3-nitrobenzoic acid methyl ester
  • 5-fluoro-N,2-dimethylbenzamide

Uses

5-Fluoro-2-methylbenzoic acid is used in preparation of novel iminothiazole derivatives as cannabinoid receptor ligands.

Synthesis

124-38-9

33184-16-6

General procedure for the synthesis of 2-methyl-5-fluorobenzoic acid from carbon dioxide: Commercially available 2-bromo-4-fluorotoluene (5 g) was dissolved in ether (appropriate amount). About 1/3 of this solution was taken and magnesium shavings (761 mg) were added and covered with ether (25 ml). Once the reaction was initiated, the remaining 2-bromo-4-fluorotoluene solution was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. The resulting Grignard reagent was poured into a mixture of ether (750 ml) containing crushed dry ice. The reaction mixture was allowed to warm up gradually to room temperature. Subsequently, the solvent was removed by evaporation and the resulting residue was dissolved in ethyl acetate (100 ml) and extracted with 1N aqueous hydrochloric acid (100 ml). The organic phase was dried with magnesium sulfate, filtered and concentrated to give 2-methyl-5-fluorobenzoic acid (2.3 g; 56% yield).1H-NMR (CDCl3) δ: 2.5 (s, 3H), 7.0-7.2 (m, 2H), 7.7 (m, 1H).

References

[1] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 83

5-Fluoro-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

2-Bromo-4-fluorotoluene N,N-Dimethylformamide Sodium chloride Sodium perborate Tetrahydrofuran Ethyl acetate Acetic acid Magnesium sulfate n-Butyllithium

Preparation Products

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View Lastest Price from 5-Fluoro-2-methylbenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Fluoro-2-methylbenzoic acid 33184-16-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Fluoro-2-methylbenzoic acid 33184-16-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
5-Fluoro-2-methylbenzoic acid 33184-16-6
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-19

33184-16-6, 5-Fluoro-2-methylbenzoic acidRelated Search:

METHYL 2-METHYL-5-FLUOROBENZOATE o-Toluic acid 4-Bromomethylbenzoic acid p-Toluic acid m-Toluic acid 2-(Trifluoromethyl)benzoic acid 4-(Chloromethyl)benzoic acid EPA 4-(Aminomethyl)benzoic acid Methyl 5-fluoro-2-methyl-3-nitrobenzoate 5-FLUORO-2-METHOXYBENZONITRILE 5-Fluoro-2-methoxyphenyl acetic acid 5-Fluoro-2-methoxyphenol 5-FLUORO-2-METHOXYACETOPHENONE 5-FLUORO-2-METHOXYBENZALDEHYDE Fluorine 5-FLUORO-2-(TRIFLUOROMETHYL)BENZOIC ACID Benzoic acid, 2-cyano-5-fluoro- (9CI)

  • 2-METHYL-5-FLUOROBENZOIC ACID
  • RARECHEM AL BO 0443
  • 5-Fluoro-2-Methyl Benzoic Acid 2-Methyl-5-Fluorobenzoic Acid
  • 5-Fluoro-2-methylbenzoic acid 99%
  • 5-Fluoro-2-methylbenzoicacid99%
  • 5-FLUORO-2-METHYLBENZOIC ACID
  • 5-FLUORO-O-TOLUIC ACID
  • Benzoic acid, 5-fluoro-2-Methyl-
  • 5-Fluoro-2-Methylbenzoic acid, 99% 5GR
  • 2-Carboxy-4-fluorotoluene, 5-Fluoro-o-toluic acid
  • 5-Fluoro-2-Methylbenzoic Acid, 97+%
  • 5-Fluoro-2-methylbenzoic
  • 5-fluoro-2-met
  • JVBLXLBINTYFPR-UHFFFAOYSA-N
  • 5-Fluoro-2-methylbenzoicAcid&gt
  • 33184-16-6
  • CARBOXYLIC ACID
  • C8
  • Carboxylic Acids
  • Carbonyl Compounds
  • Building Blocks
  • Organic Building Blocks
  • Aromatics
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Benzene series
  • Benzoic acid
  • C8
  • Carbonyl Compounds
  • Carboxylic Acids