ChemicalBook > CAS DataBase List > Phthalimide

Phthalimide

Product Name
Phthalimide
CAS No.
85-41-6
Chemical Name
Phthalimide
Synonyms
Isoindoline-1,3-dione;PHTALIMIDE;ISOINDOLE-1,3-DIONE;Phthalimid;o-Phthalimide;PHTHALIC ACID IMIDE;2H-Isoindole-1,3-dione;1H-ISOINDOLE-1,3(2H)-DIONE;Benzoimide;Ftalimmide
CBNumber
CB1280074
Molecular Formula
C8H5NO2
Formula Weight
147.13
MOL File
85-41-6.mol
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Phthalimide Property

Melting point:
232-235 °C(lit.)
Boiling point:
366 °C
Density 
1.21
vapor pressure 
0.001Pa at 25℃
refractive index 
1.4700 (estimate)
Flash point:
165 °C
storage temp. 
Store below +30°C.
solubility 
water: slightly soluble(lit.)
pka
8.3(at 25℃)
form 
Crystalline Flakes
color 
White to slightly yellow
PH
3.8 (0.6g/l, H2O)
Water Solubility 
<0.1 g/100 mL at 19.5 ºC
Sublimation 
366 ºC
Merck 
14,7373
BRN 
118522
InChIKey
XKJCHHZQLQNZHY-UHFFFAOYSA-N
LogP
1.15
CAS DataBase Reference
85-41-6(CAS DataBase Reference)
NIST Chemistry Reference
Phthalimide(85-41-6)
EPA Substance Registry System
Phthalimide (85-41-6)
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Safety

Risk Statements 
20/21/22-36/37/38-40
Safety Statements 
22-24/25
WGK Germany 
1
RTECS 
TI3920000
Autoignition Temperature
>500 °C
TSCA 
Yes
HS Code 
29251995
Hazardous Substances Data
85-41-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.07303
Product name
Phthalimide
Purity
for synthesis
Packaging
100g
Price
$30.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07303
Product name
Phthalimide
Purity
for synthesis
Packaging
500g
Price
$65.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07303
Product name
Phthalimide
Purity
for synthesis
Packaging
1kg
Price
$99.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07303
Product name
Phthalimide
Purity
for synthesis
Packaging
50kg
Price
$3240
Updated
2024/03/01
Sigma-Aldrich
Product number
240230
Product name
Phthalimide
Purity
≥99%
Packaging
50g
Price
$13.9
Updated
2024/03/01
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Phthalimide Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellowish crystalline flakes

Uses

Phthalimide, C6H4(CO)2NH, is an imide of commercial and industrial importance, forming a number of interesting derivatives. With alcoholic potash, phthalimide forms a potassium derivative, C6H4 (CO)2 NK, which, when reacted with ethyl iodide (or other alkyl halides), yields ethylphthalimide, C6H4(CO)2 N C2H5. The latter product, when hydrolyzed with an acid or alkali, further yields ethylamine [CAS: 75-04-7] C2H7N. Such reaction chains are useful in the preparation of certain primary amines and their derivatives.

Uses

Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities. Dyes and metabolites, Environmental Testing.

Uses

Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities.

Definition

ChEBI: A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.

Synthesis Reference(s)

Journal of the American Chemical Society, 111, p. 3725, 1989 DOI: 10.1021/ja00192a034
The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038
Tetrahedron Letters, 34, p. 6907, 1993 DOI: 10.1016/S0040-4039(00)91827-6

General Description

White to light tan powder. Slightly acidic.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

O-Phthalimide is an imide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). O-Phthalimide forms salts with bases.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition O-Phthalimide emits toxic fumes of nitrogen oxides.

Fire Hazard

Literature sources indicate that O-Phthalimide is combustible.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the imide from EtOH (20mL/g) (charcoal), or sublime it. For potassium phthalimide see entry in “Metal-organic Compounds”, Chapter 5. [Beilstein 21/10 V 270.]

Phthalimide Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Mini-efficient pulverizer Urea Phthalic anhydride Ammonium bicarbonate Ammonia

Preparation Products

PHTHALAMIC ACID N-(Hydroxymethyl)phthalimide 1-(1H-pyrazol-1-yl)propan-2-amine Fmoc-8-amino-3,6-dioxaoctanoic acid Phthalonitrile C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE Phthalide 4-Nitrophthalimide N-(Chloromethyl)phthalimide Captan N-(2-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]ETHYL)-3-METHOXYBENZAMIDE Benzylamine (Aminomethyl)phosphonic acid 4-Fluorobenzylamine 2-(1-Methyl-2-oxopropyl)-1H-isoindole-1,3-(2H)-dione N-Morpholinothio Phthaldamide Phosmet Ofloxacin 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE 2-(Phenoxymethyl)benzoic acid Folpet 5-Aminophthalide 1,4-DIAMINOBUTANE 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE Cyclohexylthiophthalimide
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View Lastest Price from Phthalimide manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
Phthalimide 85-41-6
Price
US $100.00-1000.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-08
Hebei Yanxi Chemical Co., Ltd.
Product
Phthalimide 85-41-6
Price
US $25.00-9.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-15
Hebei Guanlang Biotechnology Co., Ltd.
Product
Phthalimide 85-41-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2023-02-14

85-41-6, PhthalimideRelated Search:

PHTHALAMIDE Phthalic acid N-(2-Ethylhexyl)-5-norbornene-2,3-dicarboximide Maleimide Succinimide Dibutyl phthalate N-Hydroxysuccinimide Potassium phthalimide Phthalhydrazide N,N'-1,3-Phenylene bismaleimide Phthalic anhydride Bismaleimide 2,5-Diaminobenzenesulfonic acid 1-[2-(Trifluoromethyl)phenyl]hydrazine 2-Nitrodiphenylamine Dimethyl phthalate 9-Oxo Epinastine HBr 6-Chloromethylmorphanthridine

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  • 85-41-6
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  • C8H4NO2K
  • COC6H4CONH
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