Phthalimide

ChemicalBook > CAS DataBase List > Phthalimide

Product Name: Phthalimide
CAS No.: 85-41-6
Chemical Name: Phthalimide
Synonyms: Isoindoline-1,3-dione;PHTALIMIDE;ISOINDOLE-1,3-DIONE;Phthalimid;o-Phthalimide;PHTHALIC ACID IMIDE;2H-Isoindole-1,3-dione;1H-ISOINDOLE-1,3(2H)-DIONE;Benzoimide;Ftalimmide
CBNumber: CB1280074
Molecular Formula: C8H5NO2
Formula Weight: 147.13
MOL File: 85-41-6.mol

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Phthalimide Property

Melting point:: 232-235 °C(lit.)
Boiling point:: 366 °C
Density: 1.21
vapor pressure: 0.001Pa at 25℃
refractive index: 1.4700 (estimate)
Flash point:: 165 °C
storage temp.: Store below +30°C.
solubility: water: slightly soluble(lit.)
pka: 8.3(at 25℃)
form: Crystalline Flakes
color: White to slightly yellow
PH: 3.8 (0.6g/l, H2O)
Water Solubility: <0.1 g/100 mL at 19.5 ºC
Sublimation: 366 ºC
Merck: 14,7373
BRN: 118522
InChIKey: XKJCHHZQLQNZHY-UHFFFAOYSA-N
LogP: 1.15
CAS DataBase Reference: 85-41-6(CAS DataBase Reference)
NIST Chemistry Reference: Phthalimide(85-41-6)
EPA Substance Registry System: Phthalimide (85-41-6)

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Safety

Risk Statements: 20/21/22-36/37/38-40
Safety Statements: 22-24/25
WGK Germany: 1
RTECS: TI3920000
Autoignition Temperature: >500 °C
TSCA: Yes
HS Code: 29251995
Hazardous Substances Data: 85-41-6(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.07303
Product name: Phthalimide
Purity: for synthesis
Packaging: 100g
Price: $30.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.07303
Product name: Phthalimide
Purity: for synthesis
Packaging: 500g
Price: $65.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.07303
Product name: Phthalimide
Purity: for synthesis
Packaging: 1kg
Price: $99.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.07303
Product name: Phthalimide
Purity: for synthesis
Packaging: 50kg
Price: $3240
Updated: 2024/03/01

Sigma-Aldrich

Product number: 240230
Product name: Phthalimide
Purity: ≥99%
Packaging: 50g
Price: $13.9
Updated: 2024/03/01

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Phthalimide Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellowish crystalline flakes

Uses

Phthalimide, C6H4(CO)2NH, is an imide of commercial and industrial importance, forming a number of interesting derivatives. With alcoholic potash, phthalimide forms a potassium derivative, C6H4 (CO)2 NK, which, when reacted with ethyl iodide (or other alkyl halides), yields ethylphthalimide, C6H4(CO)2 N C2H5. The latter product, when hydrolyzed with an acid or alkali, further yields ethylamine [CAS: 75-04-7] C2H7N. Such reaction chains are useful in the preparation of certain primary amines and their derivatives.

Uses

Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities. Dyes and metabolites, Environmental Testing.

Definition

ChEBI: A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.

Synthesis Reference(s)

Journal of the American Chemical Society, 111, p. 3725, 1989 DOI: 10.1021/ja00192a034
The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038
Tetrahedron Letters, 34, p. 6907, 1993 DOI: 10.1016/S0040-4039(00)91827-6

General Description

White to light tan powder. Slightly acidic.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

O-Phthalimide is an imide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). O-Phthalimide forms salts with bases.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition O-Phthalimide emits toxic fumes of nitrogen oxides.

Fire Hazard

Literature sources indicate that O-Phthalimide is combustible.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the imide from EtOH (20mL/g) (charcoal), or sublime it. For potassium phthalimide see entry in “Metal-organic Compounds”, Chapter 5. [Beilstein 21/10 V 270.]

Phthalimide Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Mini-efficient pulverizer Urea Phthalic anhydride Ammonium bicarbonate Ammonia

Preparation Products

PHTHALAMIC ACID N-(Hydroxymethyl)phthalimide 1-(1H-pyrazol-1-yl)propan-2-amine Fmoc-8-amino-3,6-dioxaoctanoic acid Phthalonitrile C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE Phthalide 4-Nitrophthalimide N-(Chloromethyl)phthalimide Captan N-(2-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]ETHYL)-3-METHOXYBENZAMIDE Benzylamine (Aminomethyl)phosphonic acid 4-Fluorobenzylamine 2-(1-Methyl-2-oxopropyl)-1H-isoindole-1,3-(2H)-dione N-Morpholinothio Phthaldamide Phosmet Ofloxacin 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE 2-(Phenoxymethyl)benzoic acid Folpet 5-Aminophthalide 1,4-DIAMINOBUTANE 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE Cyclohexylthiophthalimide

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View Lastest Price from Phthalimide manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Phthalimide 85-41-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-28

Hebei Weibang Biotechnology Co., Ltd

Product: Phthalimide 85-41-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-11-29

Hebei Yanxi Chemical Co., Ltd.

Product: Phthalimide 85-41-6
Price: US $25.00-9.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-15

85-41-6, PhthalimideRelated Search:

PHTHALAMIDE Phthalic acid N-(2-Ethylhexyl)-5-norbornene-2,3-dicarboximide Maleimide Succinimide Dibutyl phthalate N-Hydroxysuccinimide Potassium phthalimide Phthalhydrazide N,N'-1,3-Phenylene bismaleimide Phthalic anhydride Bismaleimide 2,5-Diaminobenzenesulfonic acid 1-[2-(Trifluoromethyl)phenyl]hydrazine 2-Nitrodiphenylamine Dimethyl phthalate 9-Oxo Epinastine HBr 6-Chloromethylmorphanthridine

Potassium phthalylimide

LABOTEST-BB LTBB000782

ISOINDOLE-1,3-DIONE

1,3-dihydro-1,3-dioxoisoindole

PHTHALIMIDE,REAGENT

PHTHALIMIDE / 2,5-ISOINDOLEDIONE

2H-Isoindole-1,3-dione

Isoindoline-1,3-dione

Phthalimide, extra pure

PhthaliMide, 99% 100GR

The developMent of forMyl iMine

PhthaliMide 0

The adjacent benzene twoMethyl iMide

PhthaliMide, CP,98.0%

O-Phthalimide- 15N

Phthalimide Solution, 1000ppm

O-PHTHALIC IMIDE

o-Phthalimide

Phenylimide

phthalic dicarboximide

PHTHALIMIDE

PHTHALIC ACID IMIDE

PHTHALYLIMIDE

2,5-Isoindoledione

Benzene-1,2-dicarboxylic acid imide

PHTALIMIDE

PHTHALIMIDE PESTANAL

PHTHALIMIDE, 99+%

Phthalylimide99%

PhthalimideForSynthesis

COPY1,2-Benzenedicarboximide

1,2-PHTHALIC IMIDE

1,2-BENZENEDICARBOXIMIDE

1,3-DIHYDROISOINDOLE-1,3-DIONE

1,3-ISOINDOLEDIONE

1H-ISOINDOLE-1,3(2H)-DIONE

1,3-Isoindolinedione

2-Diazoindan-1,3-dione

Benzoimide

Ftalimmide

Phthalimid

Phthalimide&gt

Phthalimide,98%

PHTHALIMIDE FOR SYNTHESIS 1 KG

PHTHALIMIDE FOR SYNTHESIS 100 G

PHTHALIMIDE FOR SYNTHESIS 500 G

hthalimide

Phthalimide, GR 98%+

Rivaroxaban Impurity 85 (Phthalimide)

Epinastine Impurity 17

C16190000 Phthalimide

Rivaroxaban Impurity 51 (Phthalimide)

Butyphthalide Impurity 55

85-41-6

98%85-41-2

85-41-5

C8H4NO2K

COC6H4CONH