PHRIXOTOXIN 3

Product Name: PHRIXOTOXIN 3
CAS No.: 880886-00-0
Chemical Name: PHRIXOTOXIN 3
Synonyms: PHRIXOTOXIN 3
CBNumber: CB14724231
Molecular Formula: C176H269N51O48S6
Formula Weight: 0
MOL File: Mol file

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PHRIXOTOXIN 3 Property

storage temp.: Store at -20°C
form: Powder
Water Solubility: Soluble to 1 mg/ml in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4914
Product name: Phrixotoxin3
Packaging: 100U
Price: $292
Updated: 2021/12/16

Usbiological

Product number: 256242
Product name: Phrixotoxin 3
Packaging: 100ug
Price: $593
Updated: 2021/12/16

ApexBio Technology

Product number: B5764
Product name: Phrixotoxin3
Packaging: 100ug
Price: $423
Updated: 2021/12/16

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PHRIXOTOXIN 3 Chemical Properties,Usage,Production

Description

Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV2, NaV3 and NaV5 respectively). Blocks inward sodium currents in a voltage-dependent manner.

Uses

Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].

IC 50

Nav1.3: 42 nM (IC₅₀); Nav1.4: 72 nM (IC₅₀); Nav1.5: 610 nM (IC₅₀); Nav1.2: 0.6 nM (IC₅₀); Nav1.1: 288 nM (IC₅₀)

storage

Store at -20°C

References

[1] Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69(2): 419-29. DOI:10.1124/mol.105.015941

PHRIXOTOXIN 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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PHRIXOTOXIN 3 Suppliers

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PHRIXOTOXIN 3

880886-00-0

C176H269N51O48S6