PHRIXOTOXIN 3
- Product Name
- PHRIXOTOXIN 3
- CAS No.
- 880886-00-0
- Chemical Name
- PHRIXOTOXIN 3
- Synonyms
- PHRIXOTOXIN 3
- CBNumber
- CB14724231
- Molecular Formula
- C176H269N51O48S6
- Formula Weight
- 0
- MOL File
- Mol file
PHRIXOTOXIN 3 Property
- storage temp.
- Store at -20°C
- form
- Powder
- Water Solubility
- Soluble to 1 mg/ml in water
N-Bromosuccinimide Price
- Product number
- 4914
- Product name
- Phrixotoxin3
- Packaging
- 100U
- Price
- $292
- Updated
- 2021/12/16
- Product number
- 256242
- Product name
- Phrixotoxin 3
- Packaging
- 100ug
- Price
- $593
- Updated
- 2021/12/16
- Product number
- B5764
- Product name
- Phrixotoxin3
- Packaging
- 100ug
- Price
- $423
- Updated
- 2021/12/16
PHRIXOTOXIN 3 Chemical Properties,Usage,Production
Description
Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV2, NaV3 and NaV5 respectively). Blocks inward sodium currents in a voltage-dependent manner.
Uses
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].
IC 50
Nav1.3: 42 nM (IC50); Nav1.4: 72 nM (IC50); Nav1.5: 610 nM (IC50); Nav1.2: 0.6 nM (IC50); Nav1.1: 288 nM (IC50)
storage
Store at -20°C
References
[1] Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69(2): 419-29. DOI:10.1124/mol.105.015941