Uses
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1-Boc-3-(Amino)azetidine

Uses
Product Name
1-Boc-3-(Amino)azetidine
CAS No.
193269-78-2
Chemical Name
1-Boc-3-(Amino)azetidine
Synonyms
TERT-BUTYL 3-AMINOAZETIDINE-1-CARBOXYLATE;Boc-3-(Amino)azetidine;1-Boc-azetidin-3-amine;1-Boc-3-Aminoazatidine;3-AMINO-1-BOC-AZETIDINE;1-BOC-3-(AMINO)AZETIDINE;1-N-Boc-3-aminoazetidine;3-AMINO-1-N-BOC-AZETIDINE;1-Boc-3-Aminoazetidine Hy;1-Boc-3-aminoazetidine ,97%
CBNumber
CB2131519
Molecular Formula
C8H16N2O2
Formula Weight
172.22
MOL File
193269-78-2.mol
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1-Boc-3-(Amino)azetidine Property

Boiling point:
79-81 3mm
Density 
1.1g/ml
refractive index 
1.4650
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO, Methanol, Water
form 
Oil
pka
8.29±0.20(Predicted)
color 
Clear Colourless to Pale Yellow
InChI
InChI=1S/C8H16N2O2/c1-8(2,3)12-7(11)10-4-6(9)5-10/h6H,4-5,9H2,1-3H3
InChIKey
WPGLRFGDZJSQGI-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC(N)C1
CAS DataBase Reference
193269-78-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
34-51-22
Safety Statements 
26-36-45-36/37/39
RIDADR 
2735
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3706
Product name
tert-Butyl 3-Aminoazetidine-1-carboxylate
Purity
min. 98.0 %
Packaging
1G
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
B3706
Product name
tert-Butyl 3-Aminoazetidine-1-carboxylate
Purity
min. 98.0 %
Packaging
10G
Price
$181
Updated
2025/07/31
TRC
Product number
B600900
Product name
1-Boc-3-aminoazetidine
Packaging
250mg
Price
$120
Updated
2021/12/16
Usbiological
Product number
262870
Product name
1-Boc-3-aminoazetidine
Packaging
100mg
Price
$383
Updated
2021/12/16
TRC
Product number
B600900
Product name
1-Boc-3-aminoazetidine
Packaging
2.5g
Price
$950
Updated
2021/12/16
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1-Boc-3-(Amino)azetidine Chemical Properties,Usage,Production

Uses

1-Boc-3-(Amino)azetidine are widely used and valued as pharmaceutical intermediates. In recent years, numerous new compounds have been successfully prepared and tested through various functional group modifications, many of which exhibit good pharmaceutical activity. For example, 1-diphenylmethyl-3-aminoazacyclic butane and 1-diphenylmethyl-3-hydroxy-3-aminomethylazacyclic butane have been used in the synthesis of some antibacterial and antidepressant drugs. 1-tert-butoxycarbonyl-3-aminocyclobutane is also an important pharmaceutical intermediate used in the synthesis of IRAK-4 inhibitors.

Chemical Properties

Clear Colourless to Pale Yellow Oil

Synthesis

429672-02-6

193269-78-2

General procedure for the synthesis of tert-butyl 3-aminoazetidine-1-carboxylate from 1-BOC-3-azidoazetidine: tert-butyl 3-azidoazetidine-1-carboxylate (0.420 g, 2.19 mmol) was dissolved in EtOAc (20 mL) and 10% Pd/C (100 mg) was added. The reaction mixture was stirred under hydrogen atmosphere (balloon). After 12 h of reaction, the catalyst was removed by filtration through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give a colorless oily product (1.76 g, 99% yield), which could be used in subsequent reactions without further purification.1H NMR (CDCl3): δ 1.50 (s, 9H).

References

[1] Patent: WO2004/74283, 2004, A1. Location in patent: Page 40
[2] Patent: US2011/166121, 2011, A1. Location in patent: Page/Page column 56
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22

1-Boc-3-(Amino)azetidine Preparation Products And Raw materials

Raw materials

Xylene 3-Hydroxyazetidine hydrochloride Ethanol N,N-Dimethylformamide Potassium iodide Toluene Di-tert-butyl dicarbonate Hydrazine hydrate Triethylamine Palladium Methanesulfonyl chloride 1,4-Dioxane Imidazole Iodine Ethyl acetate Benzhydrylamine Methanol Dimethyl sulfoxide Cetyltributylphosphonium bromide Epichlorohydrin Triphenylphosphine Potassium phthalimide Citric acid

Preparation Products

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1-Boc-3-(Amino)azetidine Suppliers

Austria 1 Canada 2 China 239 Europe 1 France 1 Germany 5 India 5 Japan 1 South Korea 1 Ukraine 2 United Kingdom 11 United States 37 Global 306
Suzhou ChonTech Biopharma Co.,Ltd
Tel
0512-63101022 13912623614
Fax
86-512-6310 1035
Email
sales@chontech.com
Country
Austria
ProdList
220
Advantage
58
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View Lastest Price from 1-Boc-3-(Amino)azetidine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-Boc-3-(Amino)azetidine 193269-78-2
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-25
Hebei Chuanghai Biotechnology Co., Ltd
Product
1-Boc-3-(Amino)azetidine 193269-78-2
Price
US $10.00-8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-06
Career Henan Chemical Co
Product
1-Boc-3-(Amino)azetidine 193269-78-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
200KG
Release date
2018-08-19

193269-78-2, 1-Boc-3-(Amino)azetidineRelated Search:

RESMETHRIN ALTRENOGEST tert-Butyl carbazate Butyl acetate Salbutamol Diethylene glycol monobutyl ether Azetidine Buprofezin 3-Aminophenol BUTYL OLEATE N-Carbobenzyloxyglycine Dibutyl phthalate 6-Aminocaproic acid DOBUTAMINE Glycine Cyhalofop-butyl Tris(hydroxymethyl)aminomethane 3-(4-BROMO-PHENYLAMINO)-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

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  • 193269-78-2
  • Amines
  • Azetidine
  • Heterocyclic Compounds
  • Ring Systems
  • Heterocycles
  • Miscellaneous Reagents
  • pharmacetical
  • Heterocycles series