1-Boc-3-(Amino)azetidine

Uses

Product Name: 1-Boc-3-(Amino)azetidine
CAS No.: 193269-78-2
Chemical Name: 1-Boc-3-(Amino)azetidine
Synonyms: TERT-BUTYL 3-AMINOAZETIDINE-1-CARBOXYLATE;Boc-3-(Amino)azetidine;1-Boc-azetidin-3-amine;1-Boc-3-Aminoazatidine;3-AMINO-1-BOC-AZETIDINE;1-BOC-3-(AMINO)AZETIDINE;1-N-Boc-3-aminoazetidine;3-AMINO-1-N-BOC-AZETIDINE;1-Boc-3-Aminoazetidine Hy;1-Boc-3-aminoazetidine ,97%
CBNumber: CB2131519
Molecular Formula: C8H16N2O2
Formula Weight: 172.22
MOL File: 193269-78-2.mol

More

Less

1-Boc-3-(Amino)azetidine Property

Boiling point:: 79-81 3mm
Density: 1.1g/ml
refractive index: 1.4650
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO, Methanol, Water
form: Oil
pka: 8.29±0.20(Predicted)
color: Clear Colourless to Pale Yellow
InChI: InChI=1S/C8H16N2O2/c1-8(2,3)12-7(11)10-4-6(9)5-10/h6H,4-5,9H2,1-3H3
InChIKey: WPGLRFGDZJSQGI-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(N)C1
CAS DataBase Reference: 193269-78-2(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 34-51-22
Safety Statements: 26-36-45-36/37/39
RIDADR: 2735
Hazard Note: Irritant
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3706
Product name: tert-Butyl 3-Aminoazetidine-1-carboxylate
Purity: min. 98.0 %
Packaging: 1G
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: B3706
Product name: tert-Butyl 3-Aminoazetidine-1-carboxylate
Purity: min. 98.0 %
Packaging: 10G
Price: $181
Updated: 2025/07/31

TRC

Product number: B600900
Product name: 1-Boc-3-aminoazetidine
Packaging: 250mg
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 262870
Product name: 1-Boc-3-aminoazetidine
Packaging: 100mg
Price: $383
Updated: 2021/12/16

TRC

Product number: B600900
Product name: 1-Boc-3-aminoazetidine
Packaging: 2.5g
Price: $950
Updated: 2021/12/16

More

Less

1-Boc-3-(Amino)azetidine Chemical Properties,Usage,Production

Uses

1-Boc-3-(Amino)azetidine are widely used and valued as pharmaceutical intermediates. In recent years, numerous new compounds have been successfully prepared and tested through various functional group modifications, many of which exhibit good pharmaceutical activity. For example, 1-diphenylmethyl-3-aminoazacyclic butane and 1-diphenylmethyl-3-hydroxy-3-aminomethylazacyclic butane have been used in the synthesis of some antibacterial and antidepressant drugs. 1-tert-butoxycarbonyl-3-aminocyclobutane is also an important pharmaceutical intermediate used in the synthesis of IRAK-4 inhibitors.

Chemical Properties

Clear Colourless to Pale Yellow Oil

Synthesis

429672-02-6

193269-78-2

General procedure for the synthesis of tert-butyl 3-aminoazetidine-1-carboxylate from 1-BOC-3-azidoazetidine: tert-butyl 3-azidoazetidine-1-carboxylate (0.420 g, 2.19 mmol) was dissolved in EtOAc (20 mL) and 10% Pd/C (100 mg) was added. The reaction mixture was stirred under hydrogen atmosphere (balloon). After 12 h of reaction, the catalyst was removed by filtration through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give a colorless oily product (1.76 g, 99% yield), which could be used in subsequent reactions without further purification.1H NMR (CDCl3): δ 1.50 (s, 9H).

References

[1] Patent: WO2004/74283, 2004, A1. Location in patent: Page 40
[2] Patent: US2011/166121, 2011, A1. Location in patent: Page/Page column 56
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22

1-Boc-3-(Amino)azetidine Preparation Products And Raw materials

Raw materials

Xylene 3-Hydroxyazetidine hydrochloride Ethanol N,N-Dimethylformamide Potassium iodide Toluene Di-tert-butyl dicarbonate Hydrazine hydrate Triethylamine Palladium Methanesulfonyl chloride 1,4-Dioxane Imidazole Iodine Ethyl acetate Benzhydrylamine Methanol Dimethyl sulfoxide Cetyltributylphosphonium bromide Epichlorohydrin Triphenylphosphine Potassium phthalimide Citric acid

Preparation Products

More

Less

1-Boc-3-(Amino)azetidine Suppliers

Austria 1 Canada 2 China 239 Europe 1 France 1 Germany 5 India 5 Japan 1 South Korea 1 Ukraine 2 United Kingdom 11 United States 37 Global 306

A. B. Enterprises

Tel: --
Fax: --
Email: mlbang@rediffmail.com
Country: India
ProdList: 1394
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

SL Drugs and Pharmaceuticals Pvt. Ltd.

Tel: --
Fax: --
Email: enquiry@sldrugs.com
Country: India
ProdList: 2683
Advantage: 50

More

Less

View Lastest Price from 1-Boc-3-(Amino)azetidine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Boc-3-(Amino)azetidine 193269-78-2
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-25

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Boc-3-(Amino)azetidine 193269-78-2
Price: US $10.00-8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-06

Career Henan Chemical Co

Product: 1-Boc-3-(Amino)azetidine 193269-78-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 200KG
Release date: 2018-08-19

193269-78-2, 1-Boc-3-(Amino)azetidineRelated Search:

RESMETHRIN ALTRENOGEST tert-Butyl carbazate Butyl acetate Salbutamol Diethylene glycol monobutyl ether Azetidine Buprofezin 3-Aminophenol BUTYL OLEATE N-Carbobenzyloxyglycine Dibutyl phthalate 6-Aminocaproic acid DOBUTAMINE Glycine Cyhalofop-butyl Tris(hydroxymethyl)aminomethane 3-(4-BROMO-PHENYLAMINO)-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-Azetidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester

1-Boc-3-aminoazetidine ,97%

1-Boc-azetidin-3-amine

1-tert-Butoxycarbonyl-3-aminoazetidine

tert-Butyl 3-aminoazetidine-1-carboxylate, 3-Amino-1-(tert-butoxycarbonyl)azetidine, 3-Amino-1-(tert-butoxycarbonyl)azetane

Boc-3-(Amino)azetidine

1-Boc-3-Aminoazetidine Hy

1-Boc-3-amino-azetidine HCl

1,1-DiMethylethyl 3-AMinoazetidine-1-carboxylate

3-AMino-1-azetidinecarboxylic Acid 1,1-DiMethylethyl Ester

tert-Butyl 3-AMino-1-azetidinecarboxylate

3-Aminoazetidine,N1-BOCprotected97%

3-aminoazetidine-1-carboxylate

3-AMINO-1-N-BOC-AZETIDINE

3-AMINO-1-BOC-AZETIDINE

3-AMINO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

3-AMINO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

3-AMINOAZETIDINE, N1-BOC PROTECTED

1-BOC-3-(AMINO)AZETIDINE

1-BOC-3-AMINOAZETIDINE HYDROCHLORIDE

TERT-BUTYL 3-AMINOAZETIDINE-1-CARBOXYLATE

1-N-Boc-3-aminoazetidine

3-amino-1-azetidinecarboxylate

3-Aminoazetidine, N1-BOC protected 97%

1-Boc-3-Aminoazatidine

3-AMINO-1-BOC-AZETIDINE 98%

N-BOC-3-AMINOAZETIDINE HYDROCHLORIDE

ert-butyl3-aminoazetidine-1-carboxylate

4-Isoxazoleethanol,3,10-dimethyl-

1-tert butoxycarbonylazetidine-3-amine

3-Amino-1-(N-BOC)azetidine - [A3070]

193269-78-2

Amines

Azetidine

Heterocyclic Compounds

Ring Systems

Heterocycles

Miscellaneous Reagents

pharmacetical

Heterocycles series