Oxacycloheptadec-8-en-2-one Property

Boiling point:

355.57°C (rough estimate)

Density 

0.9615 (rough estimate)

refractive index 

1.6000 (estimate)

FEMA 

2555 | OMEGA-6-HEXADECENLACTONE

Odor

at 100.00 %. musty animal musk ambrette

Odor Type

musk

JECFA Number

240

LogP

5.516 (est)

NIST Chemistry Reference

Oxacycloheptadec-8-en-2-one(123-69-3)

EPA Substance Registry System

(Z)-Oxacycloheptadec-8-en-2-one (123-69-3)

Safety

Toxicity

LD50 orl-rat: 339 mg/kg YAKUD522,1513,80

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Oxacycloheptadec-8-en-2-one Chemical Properties,Usage,Production

Description

Although used at one time in fruit flavors, is more extensively used in perfumes and fragrances. The use of musk ambrette has been discontinued due to the toxic nature of the substance. It was removed from GRAS status by FEMA in 1984.

Uses

Musk ambrette is previously used as fragrance and fixative in after-shave lotions, perfumes, food flavor, etc.

Uses

Musk Ambrette is a reactant in the preparation of musk macrolactones, catalyzed by Candida antartica lipase B (Novozym 435).

Definition

ChEBI: (Z)-7-Hexadecen-1,16-olide is a macrolide.

Safety Profile

Poison by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.