4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

Product Name: 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
CAS No.: 349085-82-1
Chemical Name: 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
Synonyms: CS-2460;SK 137647;GSK137647;GSK137647A;GSK137647A, >98%;FFA4 (GPR120) agonist GS137647A;FFA4 (GPR120) agonist GSK137647A;Benzenesulfonamide, 4-methoxy-N-(2,4,6-trimethylphenyl)-;GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97%
CBNumber: CB22635143
Molecular Formula: C16H19NO3S
Formula Weight: 305.39
MOL File: 349085-82-1.mol

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4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Property

Boiling point:: 438.1±55.0 °C(Predicted)
Density: 1.214±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol.
form: powder
pka: 9.23±0.10(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference: 349085-82-1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1152
Product name: GSK137647A
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1152
Product name: GSK137647A
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Alfa Aesar

Product number: H57808
Product name: 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97%
Packaging: 250mg
Price: $80.6
Updated: 2021/12/16

Alfa Aesar

Product number: H57808
Product name: 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97%
Packaging: 1g
Price: $255
Updated: 2021/12/16

Cayman Chemical

Product number: 17712
Product name: GSK137647A
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

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4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Chemical Properties,Usage,Production

Description

GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2

Uses

4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.

in vitro

gsk137647a (50 μm) induced a concentration-dependent increase in glucose (25 mm)-stimulated insulin secretion in min6 mouse insulinoma cell line [1]. in addition, gsk137647a (100 μm) induced a modest increase in glp-1 secretion in the human intestinal cell line nci-h716. moreover, gsk137647a induced intracellular calcium accumulation in u2os cells [1].

in vivo

gsk137647a (50 μm) induced active glp-1 release by mouse circumvallate papillae (cvps) [2].

target

ffa4/gpr120

storage

Store at RT

References

1) Martin?et al. (2012),?Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res.,?53?2256 2) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Suppliers

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View Lastest Price from 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% manufacturers

Career Henan Chemical Co

Product: 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% 349085-82-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

349085-82-1, 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%Related Search:

GF109203X Fatostatin A EFAROXAN HYDROCHLORIDE Amlexanox N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide GSK-2126458 ABT 702 Dihydrochloride Danirixin daprodustat,GSK1278863 GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Benzyl methyl ether 4-Methoxybenzoic acid

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

GSK137647A

GSK137647

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97%

GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647

GSK137647A, >98%

CS-2460

FFA4 (GPR120) agonist GS137647A

Benzenesulfonamide, 4-methoxy-N-(2,4,6-trimethylphenyl)-

FFA4 (GPR120) agonist GSK137647A

SK 137647

349085-82-1

API