ChemicalBook > CAS DataBase List > NVP-CGM097

NVP-CGM097

Product Name
NVP-CGM097
CAS No.
1313363-54-0
Chemical Name
NVP-CGM097
Synonyms
CGM097;CS-2423;CS-1248;NVP-CGM097;NVP-CGM097 (CGM097);NVP-CGM097 (FREE BASE);NVP-CGM097 HYDROCHLORIDE (HCL SALT);CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097;(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-[methyl[4-(4-methyl-3-oxopiperazin-1-yl)-trans-cyclohexylmethyl]amino]phenyl)-1,4-dihydro-2H-isoquinolin-3-one;(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one
CBNumber
CB22715661
Molecular Formula
C38H47ClN4O4
Formula Weight
659.26
MOL File
1313363-54-0.mol
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NVP-CGM097 Property

Boiling point:
830.1±65.0 °C(Predicted)
Density 
1.210±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:50.0(Max Conc. mg/mL);75.84(Max Conc. mM)
pka
8.31±0.20(Predicted)
form 
Powder
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
29519
Product name
NVP-CGM097
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29519
Product name
NVP-CGM097
Packaging
10mg
Price
$593
Updated
2024/03/01
Cayman Chemical
Product number
29519
Product name
NVP-CGM097
Packaging
5mg
Price
$321
Updated
2024/03/01
ChemScene
Product number
CS-3138
Product name
NVP-CGM097
Purity
98.32%
Packaging
2mg
Price
$144
Updated
2021/12/16
ApexBio Technology
Product number
B4677
Product name
NVP-CGM097
Packaging
2mg
Price
$189
Updated
2021/12/16
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NVP-CGM097 Chemical Properties,Usage,Production

Biological Activity

NVP-CGM097 is a potent and selective MDM2 inhibitor with a Ki value of 1.3 nM. It binds to the p53-binding site of the MDM2 protein, disrupting its protein-protein interactions, leading to activation of the p53 pathway.

in vitro

The binding ability of NVP-CGM097 to MDM2 varies among different species. The selectivity of it for p53:MDM2 interaction is 1176-fold for p53:MDM4 interaction, 3000-fold for Ras:Raf interaction, and 1176-fold for Bcl-2:Bak, Bcl-2:Bad, Mcl- The interaction of 1:Bak, Mcl-1:NOXA, XIAP:BIR3, c-IAP:BIR3 is inactive, therefore, it is highly selective for p53:MDM2. It can significantly promote the entry of wild-type p53 into the nucleus with IC50 of 0.224 μM, indicating that it can inhibit the p53:MDM2 interaction in living cells. It promotes p53 as nucleus, resulting in cellular p53-dependent growth inhibition.

in vivo

After intravenous injection, the serum clearance of NVP-CGM097 was 5 mL/min/kg in mice, 7 mL/min/kg in rats, 3 mL/min/kg in dogs, and 3 mL/min/kg in monkeys. 4 mL/min/kg. Serum clearance of NVP-CGM097 was low in all species compared to hepatic blood flow (typically 5-10% hepatic blood flow). The half-life of NVP-CGM097 in rodents and monkeys is 6-12 hours; in dogs, the half-life is 20 hours, which is relatively longer.

target

TargetValue
hMDM2
(Cell-free assay)		 1.7 nM

NVP-CGM097 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-CGM097 Suppliers

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1313363-54-0, NVP-CGM097Related Search:

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  • CS-1248
  • CS-2423
  • CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097
  • (S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one
  • NVP-CGM097
  • CGM097
  • NVP-CGM097 (CGM097)
  • (S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-[methyl[4-(4-methyl-3-oxopiperazin-1-yl)-trans-cyclohexylmethyl]amino]phenyl)-1,4-dihydro-2H-isoquinolin-3-one
  • (S)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4r)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one hydrochloride
  • 3(2H)-Isoquinolinone, 1-(4-chlorophenyl)-1,4-dihydro-6-methoxy-7-(1-methylethoxy)-2-[4-[methyl[[trans-4-(4-methyl-3-oxo-1-piperazinyl)cyclohexyl]methyl]amino]phenyl]-, (1S)-
  • (1S)-1-(4-chlorophenyl)-1,4-dihydro-6-methoxy-7-(1-methylethoxy)-2-[4-[methyl[[<em>trans</em>-4-(4-methyl-3-oxo-1-piperazinyl)cyclohexyl]methyl]amino]phenyl]-3(2H)-isoquinolinone
  • NVP-CGM097,Ubiquitin ligase,inhibit,MDM-2/p53,E3 ligating enzyme,NVP-CGM-097,CGM 097,Ubiquitin activating enzyme,NVP CGM097,Inhibitor,E1/E2/E3 Enzyme,CGM-097,E2 conjugating enzyme,NVPCGM097,E1 activating enzyme,Ubiquitin conjugating enzyme
  • (S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,4-dihydroisoquinolin-3(2H)-one
  • NVP-CGM097 (FREE BASE)
  • NVP-CGM097 HYDROCHLORIDE (HCL SALT)
  • 1313363-54-0
  • C38H47ClN4O4