NVP-CGM097
- Product Name
- NVP-CGM097
- CAS No.
- 1313363-54-0
- Chemical Name
- NVP-CGM097
- Synonyms
- CGM097;CS-2423;CS-1248;NVP-CGM097;NVP-CGM097 (CGM097);NVP-CGM097 (FREE BASE);NVP-CGM097 HYDROCHLORIDE (HCL SALT);CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097;(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-[methyl[4-(4-methyl-3-oxopiperazin-1-yl)-trans-cyclohexylmethyl]amino]phenyl)-1,4-dihydro-2H-isoquinolin-3-one;(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one
- CBNumber
- CB22715661
- Molecular Formula
- C38H47ClN4O4
- Formula Weight
- 659.26
- MOL File
- 1313363-54-0.mol
NVP-CGM097 Property
- Boiling point:
- 830.1±65.0 °C(Predicted)
- Density
- 1.210±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:50.0(Max Conc. mg/mL);75.84(Max Conc. mM)
- pka
- 8.31±0.20(Predicted)
- form
- Powder
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 29519
- Product name
- NVP-CGM097
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29519
- Product name
- NVP-CGM097
- Packaging
- 10mg
- Price
- $593
- Updated
- 2024/03/01
- Product number
- 29519
- Product name
- NVP-CGM097
- Packaging
- 5mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- CS-3138
- Product name
- NVP-CGM097
- Purity
- 98.32%
- Packaging
- 5mg
- Price
- $264
- Updated
- 2021/12/16
- Product number
- CS-3138
- Product name
- NVP-CGM097
- Purity
- 98.32%
- Packaging
- 10mg
- Price
- $444
- Updated
- 2021/12/16
NVP-CGM097 Chemical Properties,Usage,Production
Biological Activity
NVP-CGM097 is a potent and selective MDM2 inhibitor with a Ki value of 1.3 nM. It binds to the p53-binding site of the MDM2 protein, disrupting its protein-protein interactions, leading to activation of the p53 pathway.
in vitro
The binding ability of NVP-CGM097 to MDM2 varies among different species. The selectivity of it for p53:MDM2 interaction is 1176-fold for p53:MDM4 interaction, 3000-fold for Ras:Raf interaction, and 1176-fold for Bcl-2:Bak, Bcl-2:Bad, Mcl- The interaction of 1:Bak, Mcl-1:NOXA, XIAP:BIR3, c-IAP:BIR3 is inactive, therefore, it is highly selective for p53:MDM2. It can significantly promote the entry of wild-type p53 into the nucleus with IC50 of 0.224 μM, indicating that it can inhibit the p53:MDM2 interaction in living cells. It promotes p53 as nucleus, resulting in cellular p53-dependent growth inhibition.
in vivo
After intravenous injection, the serum clearance of NVP-CGM097 was 5 mL/min/kg in mice, 7 mL/min/kg in rats, 3 mL/min/kg in dogs, and 3 mL/min/kg in monkeys. 4 mL/min/kg. Serum clearance of NVP-CGM097 was low in all species compared to hepatic blood flow (typically 5-10% hepatic blood flow). The half-life of NVP-CGM097 in rodents and monkeys is 6-12 hours; in dogs, the half-life is 20 hours, which is relatively longer.
target
| Target | Value |
| hMDM2 (Cell-free assay) | 1.7 nM |
NVP-CGM097 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-CGM097 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58