ChemicalBook > CAS DataBase List > Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2

Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2

Product Name: Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2
CAS No.: 1088715-84-7
Chemical Name: Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2
Synonyms: CS-2675;LY2510924;LY2510924 TFA salt;LY-2510924 (LY2510924);LY2510924; LY-2510924; LY 2510924;Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2;Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2A;L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7→1)-lactam;(2S,5S,8S,11R,14S,20R)-N-((S)-1-Amino-6-(isopropylamino)-1-oxohexan-2-yl)-2-benzyl-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-8-(4-(isopropylamino)butyl)-14-(naphthalen-2-ylmethyl)-3,6,9,12,15,18,23-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosane-20-carboxamide
CBNumber: CB23164837
Molecular Formula: C62H88N14O10
Formula Weight: 1189.47
MOL File: 1088715-84-7.mol

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Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Property

Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 125 mg/mL (105.09 mM)
form: Solid
pka: 9.89±0.15(Predicted)
color: White to off-white
InChIKey: IJHWVENTEFSNBC-QBSDWBABNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: L503155
Product name: LY2510924
Packaging: 1mg
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-6878
Product name: LY2510924
Purity: 99.91%
Packaging: 10mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-6878
Product name: LY2510924
Purity: 99.91%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6878
Product name: LY2510924
Purity: 99.91%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6878
Product name: LY2510924
Purity: 99.91%
Packaging: 25mg
Price: $1440
Updated: 2021/12/16

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Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Chemical Properties,Usage,Production

Uses

LY2510924 is a CXC chemokine receptor 4 inhibitor and a potential antineoplastic agent.

in vivo

LY2510924 specifically blocks SDF-1 binding to CXCR4 with IC₅₀ value of 0.079 nM, and inhibits SDF-1–induced GTP binding with K_b value of 0.38 nM. In human lymphoma U937 cells expressing endogenous CXCR4, LY2510924 inhibits SDF-1–induced cell migration with IC₅₀ value of 0.26 nM and inhibits SDF-1/CXCR4-mediated intracellular signaling. LY2510924 exhibits a concentration-dependent inhibition of SDF-1–stimulated phospho-ERK and phospho-Akt in tumor cells. Biochemical and cellular analyses reveals that LY2510924 has no apparent agonist activity^[1]. LY2510924 chiefly inhibits the proliferation of AML cells with little induction of cell death and reduces protection against chemotherapy by stromal cells^[2].

IC 50

¹²⁵I-SDF-1α-CXCR4: 79.7 pM (IC₅₀); ¹²⁵I-SDF-1α-CXCR4: 49.5 pM (Ki)

Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Suppliers

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View Lastest Price from Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 manufacturers

Career Henan Chemical Co

Product: Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2A 1088715-84-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-12

1088715-84-7, Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2Related Search:

LY 294002 Hydrochloride LY-2940094 LY2828360 LY-2562175 LY2228820 Etalocib LY2584702 LY 2784544 LY2409881 trihydrochloride LY-364947 LY 88074 (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide LY-3177833 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol LY3214996 LY2409881 LY3023414 LY2955303

Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2

LY2510924

LY2510924; LY-2510924; LY 2510924

CS-2675

Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2A

L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7→1)-lactam

(2S,5S,8S,11R,14S,20R)-N-((S)-1-Amino-6-(isopropylamino)-1-oxohexan-2-yl)-2-benzyl-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-8-(4-(isopropylamino)butyl)-14-(naphthalen-2-ylmethyl)-3,6,9,12,15,18,23-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosane-20-carboxamide

LY2510924 TFA salt

LY-2510924 (LY2510924)

1088715-84-7

C62H88N14O10