ChemicalBook > CAS DataBase List > 4,6-Dichloro-5-methoxypyrimidine

4,6-Dichloro-5-methoxypyrimidine

Product Name: 4,6-Dichloro-5-methoxypyrimidine
CAS No.: 5018-38-2
Chemical Name: 4,6-Dichloro-5-methoxypyrimidine
Synonyms: 2,4-dimethoxy-2-methylmercapyrimidine;6-Dichloro-5-MethoxypyriMidine;4,6-Dichlor-5-methoxypyrimidin;5-methox-4,6-Dichloropyrimidin;2,4-Dichloro-5-MetoxyPyriMidine;5-Methoxy-4,6-dichloropyriMidine;4,6-DICHLORO-5-METHOXYPYRIMIDINE;4,6-Dichloro-5-methoxy-1,3-diazine;Pyrimidine, 4,6-dichloro-5-methoxy-;4,6 -Dicholoro-5 Methoxy Pyrimidine
CBNumber: CB2390639
Molecular Formula: C5H4Cl2N2O
Formula Weight: 179
MOL File: 5018-38-2.mol

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4,6-Dichloro-5-methoxypyrimidine Property

Melting point:: 54-58 °C
Boiling point:: 257.8±35.0 °C(Predicted)
Density: 1.446±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Dichloromethane (Slightly)
form: Solid
pka: -4.13±0.26(Predicted)
color: White
InChI: InChI=1S/C5H4Cl2N2O/c1-10-3-4(6)8-2-9-5(3)7/h2H,1H3
InChIKey: IJQIGKLDBGKSNT-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C(OC)C(Cl)=N1
CAS DataBase Reference: 5018-38-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706485
Product name: 4,6-Dichloro-5-methoxypyrimidine
Purity: 97%
Packaging: 1g
Price: $80.9
Updated: 2023/06/20

TCI Chemical

Product number: D4723
Product name: 4,6-Dichloro-5-methoxypyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: D4723
Product name: 4,6-Dichloro-5-methoxypyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $104
Updated: 2025/07/31

TRC

Product number: D435285
Product name: 4,6-Dichloro-5-methoxypyrimidine
Packaging: 10g
Price: $110
Updated: 2021/12/16

Usbiological

Product number: 295951
Product name: 4,6-Dichloro-5-methoxypyrimidine
Packaging: 5g
Price: $345
Updated: 2021/12/16

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4,6-Dichloro-5-methoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Uses

4,6-Dichloro-5-methoxypyrimidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

5193-84-0

5018-38-2

Example 3.2 Preparation of 4,6-dichloro-5-methoxypyrimidine: 5-methoxypyrimidine-4,6-diol (96.0 g, 676 mmol) and triethylamine (95.0 mL, 680 mmol) were suspended in anhydrous toluene (1.2 L) and heated to 100-105°C. A solution of anhydrous toluene (200 mL) with trichlorophosphate (140 mL, 1.5 mol) was added slowly and dropwise over 30 min. The reaction mixture was refluxed for 1 hour and cooled to room temperature. The toluene layer was decanted and ice water was added to the residue. The heavier black oil layer was separated, dilution was continued with ice water, and the mixture was extracted with toluene (2 x 200 mL). The toluene extracts were combined and the aqueous layer discarded. The organic phase was washed sequentially with saturated sodium bicarbonate solution (2×300 mL), saturated saline (400 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the title compound 4,6-dichloro-5-methoxypyrimidine (103.4 g, 86% yield) as a white solid.1H NMR (CDCl3) δ 4.00 (s, 3H), 8.55 (s, 1H).

References

[1] Patent: US2009/286816, 2009, A1. Location in patent: Page/Page column 12
[2] Patent: EP714896, 1996, A1
[3] Patent: US2006/52398, 2006, A1. Location in patent: Page/Page column 39
[4] Patent: US5300506, 1994, A
[5] Patent: US5077293, 1991, A

4,6-Dichloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxy-5-methoxypyrimidine Phosphorus oxitrichloride

Preparation Products

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View Lastest Price from 4,6-Dichloro-5-methoxypyrimidine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,6-Dichloro-5-methoxypyrimidine 5018-38-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

R&D Scientific Inc.

Product: 4,6-Dichloro-5-methoxypyrimidine 5018-38-2
Price: US $520.00/Kg
Min. Order: 0.100Kg
Purity: 99 %
Supply Ability: 5000 Kg
Release date: 2025-04-09

Shaanxi Dideu New Materials Co. Ltd

Product: 4,6-Dichloro-5-methoxypyrimidine 5018-38-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-27

5018-38-2, 4,6-Dichloro-5-methoxypyrimidineRelated Search:

2,4-Dichloro-5-methylpyrimidine (Trifluoromethoxy)benzene 4-Methoxyphenylacetone 3-Methoxybenzaldehyde Anisole 4,6-Dichloropyrimidine p-Anisaldehyde p-Anisidine 4-Methoxybenzylchloride Sulfadiazine Pyrimidine 2,4-DICHLORO-5-METHOXYPYRIMIDINE, 98+%,2,4-Dichloro-5-methoxypyrimidine,2,4-DICHLORO-5-METHOXYPYRIMIDINE, 98+%,2,4-Dichloro-5-methoxypyrimidine 2,4-Dichloro-6-methoxypyrimidine,2,4-Dichloro-6-methoxypyrimidine 2-Methoxy-4,6-dichloropyrimidine 5-Hydroxypyrimidine 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 4,6-Dichloro-5-methoxypyrimidine

2,4-dimethoxy-2-methylmercapyrimidine

4,6-Dichlor-5-methoxypyrimidin

4,6-DICHLORO-5-METHOXYPYRIMIDINE

4,6-DICHLORO-5-METHOXYPYRIMIDINE 99%

Pyrimidine, 4,6-dichloro-5-methoxy-

2,4-Dichloro-5-MetoxyPyriMidine

5-Methoxy-4,6-dichloropyriMidine

4,6-Dichloro-5-methoxy-1,3-diazine

6-Dichloro-5-MethoxypyriMidine

4,6 -Dicholoro-5 Methoxy Pyrimidine

4,6-Dichloro-5-methoxypyrimidine &gt

4,6-Dichloro-5-methoxypyrimidine ISO 9001：2015 REACH

5-methox-4,6-Dichloropyrimidin

5018-38-2 4,6-Dichloro-5-methoxypyrimidine

4,6-Dichloro-5-methoxypyrimidine, CAS 5018-38-2

5018-38-2

C5H4N2OCl2

Heterocycle-Pyrimidine series

Halides

Pyrazines, Pyrimidines & Pyridazines

Pyrimidine Derivertives

Pyrimidine series

APIs & Intermediate

Pyrimidine