Alachlor
description Chemical Properties Uses Toxicity Preparation Precaution- Product Name
- Alachlor
- CAS No.
- 15972-60-8
- Chemical Name
- Alachlor
- Synonyms
- La20;Lazo;CDMA;Nudor;LASSO;Lariat;Alagan;CURFEW;CATTCH;LACORN
- CBNumber
- CB2437008
- Molecular Formula
- C14H20ClNO2
- Formula Weight
- 269.77
- MOL File
- 15972-60-8.mol
Alachlor Property
- Melting point:
- 39-42°C
- Boiling point:
- 100°C (0.02 mmHg)
- Density
- d2515.6 1.133
- refractive index
- 1.5388 (estimate)
- Flash point:
- -18 °C
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml,DMSO: 30 mg/ml
- pka
- 1.20±0.50(Predicted)
- Water Solubility
- 0.024 g/100 mL
- Merck
- 13,201
- BRN
- 2944476
- CAS DataBase Reference
- 15972-60-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Alachlor(15972-60-8)
- EPA Substance Registry System
- Alachlor (15972-60-8)
Safety
- Hazard Codes
- Xn;N,N,Xn,F,T
- Risk Statements
- 22-40-43-50/53-67-65-38-11-52/53-39/23/24/25-23/24/25-51/53
- Safety Statements
- 36/37-46-60-61-62-45-16
- RIDADR
- UN 3077
- WGK Germany
- 3
- RTECS
- AE1225000
- HazardClass
- 9
- PackingGroup
- III
- Hazardous Substances Data
- 15972-60-8(Hazardous Substances Data)
- Toxicity
- LD50 orally in rats: 1200 mg/kg (Evans)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H351Suspected of causing cancer
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 08288
- Product name
- Alachlor
- Purity
- certified reference material, TraceCERT
- Packaging
- 100mg
- Price
- $366
- Updated
- 2024/03/01
- Product number
- 41089
- Product name
- Alachlor solution
- Purity
- certified reference material, 1000?μg/mL in methanol
- Packaging
- 1mL
- Price
- $34
- Updated
- 2022/05/15
- Product number
- 45316
- Product name
- Alachlor
- Purity
- PESTANAL?, analytical standard
- Packaging
- 250mg
- Price
- $36.5
- Updated
- 2024/03/01
- Product number
- A450800
- Product name
- Alachlor
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- S247
- Product name
- Alachlor
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
Alachlor Chemical Properties,Usage,Production
description
Alachlor is a pre- and postemergence herbicide used to control annual grasses and many broad-leaved weeds in corn and in many other crops. There are liquid, dry flowable, microencapsulated, and granular formulations. Alachlor is applied by ground, aerial, and chemigation equipment. It can also be mixed with dry bulk fertilizer. It is lost from soil mainly through volatilization, photodegradation, and biodegradation. Alachlor and its degradation products may be found in soil, groundwater, and surface water.
Chemical Properties
Alachlor is a cream-colored or white solid that dissolves readily in acetone, benzene, and ethanol, but dissolves only slightly in water. It resists breakdown by ultraviolet radiation, but reacts with water under strongly acidic or alkaline conditions.
Uses
It can be used as selective herbicide for dryland bud. If a plant bud absorbs the agent, it can inhibit the activity of the protease and hinder protein synthesis, resulting in the death of weeds. It is mainly used for the germination of weeds in the soil before the seedlings, which is basically ineffective for the unearthed weeds. It can prevent annual grasses in the fields of dryland crops such as soybean, cotton, sugar beet, corn, peanut and rape, such as barnyard grass, Goosegrass, autumn grass, crabgrass, Goosegrass, Setaria, Brachiaria etc.
Toxicity
Alachlor is slightly to practically nontoxic to birds, mammals, and honey bees; highly to moderately toxic to freshwater fish; and highly toxic to aquatic plants.
The acute oral LD50 for rats is 1200mg/kg. The acute percutaneous LD50 for rabbits is 5000mg/kg (13300mg/kg). Acute inhalation is LC50>1.04mg/L in rats. The non action dose of 90d in rats is 17mg/kg, and the chronic non action dose is 2.5mg/kg. It is of no teratogenicity and mutagenesis. Bronchioloalveolar tumors and liver and lung tumors can be found at 15mg/kg and 240 ~ 260mg/kg doses in mice. For carp it is LC503.72mg/L.
Preparation
Alachlor can be synthesized in the following manner:
Precaution
- If there is no rain in the half month after the use of Methamide, watering or shallow mixed soil should be carried out to ensure the efficacy. But the accumulation of soil water is easy to take place.
- Methamide has a certain stimulating effect on the eyes and skin. Care should be paid to the administration and dispensation. If splashed into the eyes and skin, it should be cleaned immediately.
- Sorghum, millet, cucumber, melon, carrots, spinach, leeks are sensitive to alachlor and it should not be used for these plants.
- Methamide should be kept at the temperature above 0℃, and the crystallization will appear at less than 0℃. The crystallized Methamide emulsion can be recovered at 15 - 20 ℃, which does not affect the efficacy of the drug. 5. Alachlor emulsion can dissolve poly vinyl chloride, acrylonitrile, butadiene, styrene plastic and other plastic products. Therefore, this kind of material can not be used as a packing container, without corrosion to metal such as aluminum, iron, stainless steel etc.
Description
Alachlor is a herbicide. Occupational contact dermatitis was rarely observed in agricultural workers.
Chemical Properties
Alachlor is a colorless to yellow crystal chemical substance. It is soluble in most organic solvents, but sparingly in water. Alachlor is an RUP, therefore it should be purchased and used only by certified, trained workers and plant protection applicators. The US EPA categorizes it as toxicity class III, meaning slightly toxic. However, alachlor products bear the signal word danger on their labels because of their potential to cause cancer in laboratory animals. Alachlor is an aniline herbicide used to control annual grasses and broadleaf weeds in field corn, soybeans, and peanuts. It is a selective systemic herbicide, absorbed by germinating shoots and roots. It works by interfering with a plant's ability to produce protein and by interfering with root elongation. Alachlor has extensive use as a herbicide in the United States. It is available as granules or emulsifiable concentrate.
Uses
Alachlor is used pre- or early post-emergence to control annual grasses and many broadleaved weeds mainly in maize, but also in cotton, brassicas, oilseed rape, peanuts, radish, soy beans, and sugar-cane.
Uses
Alachlor is one of the most widely used herbicides in the United States and is used as an herbicide for grasses, broadleaf seeds, corn, sorghum, soybeans, peanuts, cotton, vegetables, and forage crops.
Uses
Preemergence, early postemergence or soil-incorporated herbicide used to control most annual grasses and many annual broad-leaved weeds in beans, corn, cotton, milo, peanuts, peas, soybeans, sunflower and certain woody ornamentals.
Definition
ChEBI: An aromatic amide that is N-(2,6-diethylphenyl)acetamide substituted by a methoxymethyl group at at the nitrogen atom while one of the hydrogens of the methyl group has been replaced by a chlorine atom.
General Description
Crystalline solid. Melting point 104-106°F (40-41°C). Used as a herbicide.
Air & Water Reactions
Hydrolyzes under strongly acidic and strongly basic conditions.
Reactivity Profile
A halogenated acetamide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
Alachlor is a slightly toxic herbicide. It causes slight to moderate degrees of skin irritation. While a 90-day study on laboratory rats and dogs given diets containing low to moderate amounts of alachlor (1–100 mg/kg/day) showed no adverse effects, a 1-year study indicated that at a dose above 1 mg/kg/day, alachlor causes damage in the liver, spleen, and kidney.
Agricultural Uses
Herbicide: A pre-emergence herbicide for corn, soybeans, and peanuts, and other field crops. It is a selective systemic herbicide, absorbed by germinating shoots and by roots. It works by interfering with a plant's ability to produce protein and by interfering with root elongation. It is available as granules or emulsifiable concentrate. Alachlor is used in mixed formulations with atrazine, glyphosate, trifluralin, and imaquin. Not approved for use in the EU. A U.S. EPA restricted Use Pesticide (RUP).
Trade name
AGIMIX® Araclor; ALAGAM®; ALAGAN®; ALANEX®; ALAPAZ®, suspended; ALAZINE®; ALATOX 480®; ALCLOR 48 LE®; CHIMICHLOR®; LARIAT®; LASAGRIN®; LASSAGRIN®; LASSO®; LASSO MICRO-TECH®; METACHLOR®; PARTNER® Arachlor; PILLARZO®; SANACHLOR®
Contact allergens
Alachlor is a herbicide. Occupational contact dermatitis was rarely observed in agricultural workers.
Safety Profile
Moderately toxic by ingestion, skin contact, and possibly other routes. Questionable carcinogen with experimental carcinogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.
Potential Exposure
A chloracetanilide herbicide. In manufacture, formulation and application of this preemergence herbicide, personnel may be exposed. Its major use (99%) is as a preemergence herbicide for field crops (corn, soybeans, and peanuts, etc.).
Environmental Fate
Alachlor dissipates from soil mainly through volatilization, photodegradation, and biodegradation. Many metabolites have been identified; diethylaniline, detected in some soil studies, interacts rapidly with humic substances in the soil. A half-life in soil of 7-38 days has been reported. Under certain conditions, alachlor can leach beyond the root zone and migrate to groundwater.
Metabolic pathway
The metabolism of alachlor using in vitro incubations
with microsomal fractions prepared from liver and
nasal turbinate tissues of rat and mouse (m1) results
in conversion to 3,5-diethylbenzoquinone-4-imine via
the key intermediate of 2,6-diethylaniline, the formation of which requires catalysis by microsomal
arylamidases. 2,6-Diethylaniline is oxidized to 4-amino-
3,5-diethylphenol resulting in quinone imine by further
oxidation. Rat nasal tissue possesses high enzymatic
activity which can promote the formation of the
reactive quinone imine. A methylsulfide metabolite of
alachlor is shown to be a precursor to 2,6-
diethylaniline. The deposition of radioactivity in the rat
nasal tissue is more pronounced following oral
administration of the methylsulfide metabolite of
alachlor.
The extent of DNA adduct formation by alachlor
and its metabolites is used as a guide to deduce the
causal agent(s) in the carcinogenicity of this herbicide.
Metabolic studies (m2) indicate that 2-chloro-N-
hydroxymethoxymethyl-N-(2,6-diethylphenyl)-
acetamide is an intermediate in forming 2-chloro-N-
(2,6-diethylphenyl)acetamide and presumably
formaldehyde in the mouse liver microsomal mixed-
function oxidase system and in yielding O-glucuronide of 2-chloro-N-hydroxymethyl-N-(2,6-
diethylphenyl)acetamide in the urine of alachlor-treated
mice.
Incubation of alachlor in the presence of
glutathione (GSH) with the cytosolic fraction from rat,
mouse, and monkey (m3) produces the GSH
conjugate of alachlor as the initial metabolite. The
conjugation occurs through thiol displacement of the
chlorine atom of alachlor and is catalyzed by
glutathione S-transferase (GST). Kidney cell-free
preparations of rats and monkeys readily degrade the
alachlor GSH conjugate through the mercapturic acid
pathway to the corresponding cysteinylglycine,
cysteine, and N-acetylcysteine conjugates of alachlor.
Upon UV irradiation, 14/13C-alachlor is
dechlorinated and forms a number of intermediates
that retain the aromatic ring and carbonyl carbons.
These compounds include hydroxyalachlor,
norchloralachlor, 2' ,6'-diethylacetanilide, 2-hydroxy-
2' ,6' -diethyl-N-methylacetanilide, and a lactam. The
fungus transforms 98.6% of 14C-alachlor added to the
fermentation broth, and metabolism occurs
predominantly by benzylic hydroxylation of one of the
arylethyl side chains. Two major metabolites are
isomers of 2-chloro-N-(methoxymethyl)-N-[2-ethyl-6-(1-
hydroxyethyl)-phenyl]acetamide and 2-chloro-N-(2,6-
diethylphenyl)acetamide. The minor metabolite is
2-chloro-N-(methoxymethyl)-N-(2-vinyl-6-
ethlyphenyl)acetamide. N-Dealkylation by fungal
biotransformation is also observed.
Shipping
UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Toxicity evaluation
Alachlor has a low persistence in soil, with a half-life ofz8 days. The main means of degradation is by soil microbes. It has moderate mobility in sandy and silty soils, and thus can migrate to groundwater. The largest groundwater-testing program for a pesticide, the National Alachlor Well Water Survey, was conducted throughout the last half of the 1980s. More than sixmillion private and domestic wells were tested for the presence of alachlor. Less than 1% of all of the wells had detectable levels of alachlor. In the wells in which the compound was detected, concentrations ranged from 0.1 to 1.0 mg l-1, with themajority having concentrations≈0.2mg l-1. Alachlor is relatively stable to hydrolysis and photolysis in water, and degradation in water is not considered as an important environmental fate process. Alachlor appears to be persistent under aquifer biological and geochemical conditions. This means that alachlor can appear in groundwater years after use and can migrate with groundwater away from use areas. Alachlor contamination has resulted in loss of untreated groundwater as a source of drinking water in Florida and other states. The bioaccumulation factor in the channel catfish is 5.8 times the ambient water concentration, indicating that alachlor is not expected to accumulate appreciably in aquatic organisms.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Corrosive to iron and steel.
Waste Disposal
This compound is hydrolyzed under strongly acid or alkaline conditions, to chloroacetic acid, methanol, formaldehyde and 2,6-diethylanilne. Incineration is recommended as a disposal procedure. Techniques for alachlor removal from potable water have been reviewed by EPA but the data revealed no superior method. Improper disposal of pesticides is a violation of federal law. Dispose In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers.
Alachlor Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Alachlor manufacturers
- Product
- Alachlor 15972-60-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-20