ChemicalBook > CAS DataBase List > Methyl-4-amino-3-fluorobenzoate

Methyl-4-amino-3-fluorobenzoate

Uses

Product Name: Methyl-4-amino-3-fluorobenzoate
CAS No.: 185629-32-7
Chemical Name: Methyl-4-amino-3-fluorobenzoate
Synonyms: Methyl 3-fluoro-4-aMinobenzoate;Methyl-4-amino-3-fluorobenzoate;2-Fluoro-4-(methoxycarbonyl)aniline;3-Fluoro-4-aminobenzoic acid methyl ester;Benzoic acid, 4-aMino-3-fluoro-, Methyl ester
CBNumber: CB31114657
Molecular Formula: C8H8FNO2
Formula Weight: 169.15
MOL File: Mol file

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Methyl-4-amino-3-fluorobenzoate Property

Melting point:: 109-110°C
Boiling point:: 296℃
Density: 1.264
Flash point:: 133℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: powder
pka: 1.07±0.10(Predicted)
color: White to off-white

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Safety

Risk Statements: 36/37/38
Safety Statements: 22-24/25-36/37/39-45
HazardClass: IRRITANT
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: M286640
Product name: Methyl4-Amino-3-fluorobenzoate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-M0954
Product name: methyl4-amino-3-fluorobenzoate
Purity: 98.18%
Packaging: 25g
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 047030
Product name: Methyl 4-amino-3-fluorobenzenecarboxylate
Purity: 95+%
Packaging: 25g
Price: $59
Updated: 2021/12/16

Apolloscientific

Product number: PC8633
Product name: Methyl4-amino-3-fluorobenzoate
Packaging: 5g
Price: $22
Updated: 2021/12/16

AK Scientific

Product number: W4014
Product name: Methyl4-amino-3-fluorobenzoate
Packaging: 1g
Price: $63
Updated: 2021/12/16

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Methyl-4-amino-3-fluorobenzoate Chemical Properties,Usage,Production

Uses

4-Amino-3-fluorophenylcarboxylic acid methyl ester is a carboxylic acid ester derivative that can be used as a pharmaceutical intermediate.

Chemical Properties

Brown solid

Synthesis

185629-31-6

185629-32-7

General procedure for the synthesis of methyl 4-amino-3-fluorobenzoate from methyl 3-fluoro-4-nitrobenzoate: Methyl 3-fluoro-4-nitrobenzoate (2.50 g, 12.5 mmol) and Pd/C catalyst (300 mg, 10 wt%) were placed in a 1:1 EtOAc/EtOH solvent mixture (40 mL). The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 16 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford methyl 4-amino-3-fluorobenzoate (2.1 g, 99% yield) as a beige solid. Mass spectrometry analysis (ES+): the theoretical molecular weight of C8H8FNO2 was 169 and the measured value was 170 [M + H]+.

References

[1] Patent: WO2018/81276, 2018, A1. Location in patent: Page/Page column 154
[2] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0096; 0097
[3] Patent: WO2007/16392, 2007, A2. Location in patent: Page/Page column 48
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359
[5] Patent: US2003/232889, 2003, A1. Location in patent: Page/Page column 15

Methyl-4-amino-3-fluorobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl-4-amino-3-fluorobenzoate manufacturers

Career Henan Chemical Co

Product: Methyl-4-amino-3-fluorobenzoate 185629-32-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-12

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Methyl-4-amino-3-fluorobenzoate

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185629-32-7