Methyl-4-amino-3-fluorobenzoate
Uses- Product Name
- Methyl-4-amino-3-fluorobenzoate
- CAS No.
- 185629-32-7
- Chemical Name
- Methyl-4-amino-3-fluorobenzoate
- Synonyms
- Methyl 3-fluoro-4-aMinobenzoate;Methyl-4-amino-3-fluorobenzoate;2-Fluoro-4-(methoxycarbonyl)aniline;3-Fluoro-4-aminobenzoic acid methyl ester;Benzoic acid, 4-aMino-3-fluoro-, Methyl ester
- CBNumber
- CB31114657
- Molecular Formula
- C8H8FNO2
- Formula Weight
- 169.15
- MOL File
- Mol file
Methyl-4-amino-3-fluorobenzoate Property
- Melting point:
- 109-110°C
- Boiling point:
- 296℃
- Density
- 1.264
- Flash point:
- 133℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder
- pka
- 1.07±0.10(Predicted)
- color
- White to off-white
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36/37/39-45
- HazardClass
- IRRITANT
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M286640
- Product name
- Methyl4-Amino-3-fluorobenzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-M0954
- Product name
- methyl4-amino-3-fluorobenzoate
- Purity
- 98.18%
- Packaging
- 25g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 047030
- Product name
- Methyl 4-amino-3-fluorobenzenecarboxylate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- PC8633
- Product name
- Methyl4-amino-3-fluorobenzoate
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- W4014
- Product name
- Methyl4-amino-3-fluorobenzoate
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
Methyl-4-amino-3-fluorobenzoate Chemical Properties,Usage,Production
Uses
4-Amino-3-fluorophenylcarboxylic acid methyl ester is a carboxylic acid ester derivative that can be used as a pharmaceutical intermediate.
Chemical Properties
Brown solid
Synthesis
185629-31-6
185629-32-7
General procedure for the synthesis of methyl 4-amino-3-fluorobenzoate from methyl 3-fluoro-4-nitrobenzoate: Methyl 3-fluoro-4-nitrobenzoate (2.50 g, 12.5 mmol) and Pd/C catalyst (300 mg, 10 wt%) were placed in a 1:1 EtOAc/EtOH solvent mixture (40 mL). The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 16 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford methyl 4-amino-3-fluorobenzoate (2.1 g, 99% yield) as a beige solid. Mass spectrometry analysis (ES+): the theoretical molecular weight of C8H8FNO2 was 169 and the measured value was 170 [M + H]+.
References
[1] Patent: WO2018/81276, 2018, A1. Location in patent: Page/Page column 154
[2] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0096; 0097
[3] Patent: WO2007/16392, 2007, A2. Location in patent: Page/Page column 48
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359
[5] Patent: US2003/232889, 2003, A1. Location in patent: Page/Page column 15
Methyl-4-amino-3-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl-4-amino-3-fluorobenzoate Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from Methyl-4-amino-3-fluorobenzoate manufacturers
- Product
- Methyl-4-amino-3-fluorobenzoate 185629-32-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12