ChemicalBook > CAS DataBase List > 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

Product Name
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
CAS No.
5552-44-3
Chemical Name
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
Synonyms
Nsc79261;Diethyl isocinchomeronate;ethyl 2,5-pyridinedicarboxylate;DIETHYL 2,5-PYRIDINEDICARBOXYLATE;Diethyl pyridine-2,5-dicarboxylate;Isocinchomeronic acid diethyl ester;2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;Pyridine-2,5-dicarboxylic acid diethyl ester;2,5-Pyridinedicarboxylic acid, 2,5-diethyl ester;2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 98+%
CBNumber
CB3122828
Molecular Formula
C11H13NO4
Formula Weight
223.23
MOL File
5552-44-3.mol
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2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER Property

Melting point:
46 °C
Boiling point:
181 °C / 17mmHg
Density 
1.165±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
-0.10±0.10(Predicted)
color 
White to Gray to Brown
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Safety

HS Code 
2933.39.9200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P1094
Product name
Diethyl 2,5-Pyridinedicarboxylate
Purity
>98.0%(GC)
Packaging
10g
Price
$135
Updated
2025/07/31
TRC
Product number
D476998
Product name
DiethylPyridine-2,5-dicarboxylate
Packaging
100mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
W6951
Product name
Diethylpyridine-2,5-dicarboxylate
Packaging
10g
Price
$307
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0008161
Product name
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
Purity
95.00%
Packaging
5MG
Price
$502.68
Updated
2021/12/16
Advanced Chemicals Intermediatesced Chemicals Intermediates
Product number
JL-11C-003
Product name
Pyridine-2,5-dicarboxylicaciddiethylester
Purity
95%+
Packaging
1g
Price
$29
Updated
2021/12/16
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2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER Chemical Properties,Usage,Production

Synthesis

100-26-5

64-17-5

5552-44-3

Concentrated sulfuric acid (3.9 mL, 71.6 mmol) was slowly added dropwise to a stirred suspension of 2,5-pyridinedicarboxylic acid (3.0 g, 17.9 mmol) in anhydrous ethanol (10 mL) over 15 minutes. Subsequently, the reaction mixture was heated to reflux for 18 hours. Upon completion of the reaction, the solution was cooled to room temperature and the solvent was removed by evaporation under reduced pressure. Saturated sodium bicarbonate (NaHCO3) solution was added to the residue and the pH was adjusted to 7-8. Next, the aqueous phase was extracted with ethyl acetate (EtOAc, 4 x 50 mL). All organic extracts were combined and washed with brine (30 mL) and subsequently dried with anhydrous sodium sulfate (Na2SO4). Finally, the solvent was evaporated under reduced pressure to afford diethyl 2,5-pyridinedicarboxylate (3.0 g, 75% yield), which could be used for subsequent experiments without further purification.

References

[1] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 24, p. 3025 - 3028
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 6, p. 469 - 480
[3] Dalton Transactions, 2015, vol. 44, # 35, p. 15391 - 15395
[4] European Journal of Organic Chemistry, 2010, # 1, p. 174 - 182
[5] CrystEngComm, 2011, vol. 13, # 8, p. 2915 - 2922

2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER Suppliers

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View Lastest Price from 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,5-Pyridinedicarboxylicacid, 2,5-diethyl ester 5552-44-3
Price
US $2.00-5.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-10
Career Henan Chemical Co
Product
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 5552-44-3
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

5552-44-3, 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTERRelated Search:

2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER Methyl 6-(hydroxymethyl)nicotinate 6-Methylpyridine-3-carboxylic acid DIMETHYL PYRIDINE-2,5-DICARBOXYLATE ETHYL 6-METHYLPYRIDINE-3-CARBOXYLATE 2-FORMYL-5-PICOLINE 5-METHYLPICOLINIC ACID Methyl 6-methylnicotinate 5-(Methoxycarbonyl)pyridine-2-carboxylic acid 2,5-PYRIDINEDICARBOXYLIC ACID DI-N-PROPYL ESTER METHYL 6-FORMYLNICOTINATE Ethyl picolinate 2,5-PYRIDINEDICARBOXYLIC ACID 5-ETHYL-2,3-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 2,3-Pyridinedicarboxylic acid diethyl ester 1,4-Dihydro-2,6-dimethyl-1-[2-(4-morpholinyl)ethyl]-4-[2-(trifluoromethyl)phenyl]-3,5-pyridinedicarboxylic acid diethyl ester Lacidipine 1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

  • DIETHYL 2,5-PYRIDINEDICARBOXYLATE
  • Nsc79261
  • Diethyl pyridine-2,5-dicarboxylate
  • 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
  • 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 98+%
  • Diethyl isocinchomeronate
  • Isocinchomeronic acid diethyl ester
  • Pyridine-2,5-dicarboxylic acid diethyl ester
  • 2,5-Pyridinedicarboxylic acid, 2,5-diethyl ester
  • ethyl 2,5-pyridinedicarboxylate
  • 5552-44-3
  • Heterocycle-Pyridine series