5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide

ChemicalBook > CAS DataBase List > 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide

Product Name: 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide
CAS No.: 944261-79-4
Chemical Name: 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide
Synonyms: brgt;CS-374;A 803467;[3H]-A-803467;A-803467, >98%;A-803467, >=99%;A803467;A 803467;-dimethoxyphenylamide;5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-;5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
CBNumber: CB31471262
Molecular Formula: C19H16ClNO4
Formula Weight: 357.79
MOL File: 944261-79-4.mol

Less

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide Property

Melting point:: 128-130?C
Boiling point:: 450.6±45.0 °C(Predicted)
Density: 1.294±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >10mg/mL
form: powder
pka: 11.72±0.70(Predicted)
color: white to tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3109
Product name: A-803467
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $174
Updated: 2024/03/01

Sigma-Aldrich

Product number: A3109
Product name: A-803467
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $279.6
Updated: 2024/03/01

Alfa Aesar

Product number: J67281
Product name: A-803467, 98%
Packaging: 5mg
Price: $78.2
Updated: 2023/06/20

Alfa Aesar

Product number: J67281
Product name: A-803467, 98%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

Cayman Chemical

Product number: 10012588
Product name: A-803467
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Less

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide Chemical Properties,Usage,Production

Description

Na_v1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Na_v1.8 sodium channels (IC₅₀ = 8 nM when stimulated at half-maximal inactivation and IC₅₀ = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Chemical Properties

White Solid

Uses

A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain. Analgesic.

General Description

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Biological Activity

Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Biochem/physiol Actions

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

storage

+4°C

References

1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520 2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide Suppliers

Canada 1 China 97 Germany 1 India 1 United Kingdom 2 United States 16 Global 118

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

AF Biochem Co., Ltd.

Tel: +86-028-60911900 13540204019
Email: sales@afbiochem.com
Country: China
ProdList: 493
Advantage: 57

Shanghai Sphchem Co., Ltd.

Tel: 21-21-56491756 13512199871
Fax: 021-5649-1756
Email: sales@panhongchem.com
Country: China
ProdList: 4000
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4659
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 13901585132
Fax: +86-25-52131256
Email: 799750417@qq.com
Country: China
ProdList: 8888
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

GIHI CHEMICALS CO.,LTD

Tel: 0086-571-86217390
Fax: 0086-571-86217391
Email: Sales@gihichem.com
Country: China
ProdList: 861
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9798
Advantage: 50

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5943
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9767
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9638
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: 3429815786 13301662590
Fax: +86-21-51619052
Email: sales@atkchemical.com
Country: China
ProdList: 10006
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: order@changyanchem.com
Country: China
ProdList: 5008
Advantage: 55

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1503
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3501
Advantage: 55

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14623
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9038
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1836
Advantage: 55

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7580
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28821
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15503
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3242
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Less

View Lastest Price from 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide manufacturers

Career Henan Chemical Co

Product: 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide 944261-79-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

944261-79-4, 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamideRelated Search:

Ranolazine dihydrochloride Tetracaine hydrochloride Aconitine VERATRIDINE TETRODOTOXIN QX-314 L-KAWAIN BENZAMIL HYDROCHLORIDE Procainamide hydrochloride Linocaine hydrochloride Bupivacaine Hydrochloride Lamotrigine N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride SDZ-201 106 (+/-) PD 85639 BATRACHOTOXIN A-803467 CHEMBRDG-BB 5929971

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide

A 803467

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-

5-4(-Chlorophenyl)-N-(3,5-diMethoxyphenyl)furan-2-carboxaMide

2-FurancarboxaMide,5-(4-chlorophenyl)-N-(3,5-diMethoxyphenyl)-

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5

A-803467, >=99%

A803467;A 803467

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5lt

brgt

-dimethoxyphenylamide

A-803467, >98%

CS-374

[3H]-A-803467

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide USP/EP/BP

944261-79-4

Ion Channels

Inhibitors

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sodium channel

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Property

Safety

Hazard and Precautionary Statements (GHS)

N-Bromosuccinimide Price

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Chemical Properties,Usage,Production

Description

Chemical Properties

Uses

General Description

Biological Activity

Biochem/physiol Actions

storage

References

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Suppliers

View Lastest Price from 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide manufacturers

944261-79-4, 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamideRelated Search: