5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
- Product Name
- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
- CAS No.
- 944261-79-4
- Chemical Name
- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
- Synonyms
- brgt;CS-374;A 803467;[3H]-A-803467;A-803467, >98%;A-803467, >=99%;A803467;A 803467;-dimethoxyphenylamide;5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-;5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
- CBNumber
- CB31471262
- Molecular Formula
- C19H16ClNO4
- Formula Weight
- 357.79
- MOL File
- 944261-79-4.mol
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Property
- Melting point:
- 128-130?C
- Boiling point:
- 450.6±45.0 °C(Predicted)
- Density
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: >10mg/mL
- form
- powder
- pka
- 11.72±0.70(Predicted)
- color
- white to tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- A3109
- Product name
- A-803467
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $174
- Updated
- 2024/03/01
- Product number
- A3109
- Product name
- A-803467
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $279.6
- Updated
- 2024/03/01
- Product number
- J67281
- Product name
- A-803467, 98%
- Packaging
- 5mg
- Price
- $78.2
- Updated
- 2023/06/20
- Product number
- J67281
- Product name
- A-803467, 98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 10012588
- Product name
- A-803467
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Chemical Properties,Usage,Production
Description
Nav1.8 is a tetrodotoxin-
Chemical Properties
White Solid
Uses
A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain. Analgesic.
General Description
The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.
Biological Activity
Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.
Biochem/physiol Actions
A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.
storage
+4°C
References
1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520 2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide manufacturers
- Product
- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide 944261-79-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05