Aminooxy-PEG4-azide
- Product Name
- Aminooxy-PEG4-azide
- CAS No.
- 2100306-61-2
- Chemical Name
- Aminooxy-PEG4-azide
- Synonyms
- N3-PEG5-O-NH2;Aminooxy-PEG4-azide;O-(14-Azido-3,6,9,12-tetraoxatetradecyl)hydroxylamine
- CBNumber
- CB33373560
- Molecular Formula
- C10H22N4O5
- Formula Weight
- 278.31
- MOL File
- 2100306-61-2.mol
N-Bromosuccinimide Price
- Product number
- BP-23595
- Product name
- Aminooxy-PEG4-azide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- BP-23595
- Product name
- Aminooxy-PEG4-azide
- Purity
- 98%
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- BP-23595
- Product name
- Aminooxy-PEG4-azide
- Purity
- 98%
- Packaging
- 500mg
- Price
- $880
- Updated
- 2021/12/16
Aminooxy-PEG4-azide Chemical Properties,Usage,Production
Description
Aminooxy-PEG4-azide is a heterobifunctional crosslinker containing an aminooxy group and an azide group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses
Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
Aminooxy-PEG4-azide Preparation Products And Raw materials
Raw materials
Preparation Products
Aminooxy-PEG4-azide Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
View Lastest Price from Aminooxy-PEG4-azide manufacturers
- Product
- Aminooxy-PEG4-azide 2100306-61-2
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-22