LOXO-292

ChemicalBook > CAS DataBase List > LOXO-292

Product Name: LOXO-292
CAS No.: 2152628-33-4
Chemical Name: LOXO-292
Synonyms: SELPERCATINIB;LOX-292;CPD2206;LOX0292;LOXO-292;ARRY-192);Serpatinib;LOXO-292 USP/EP/BP;Inhibitor LOXO-292;LOXO-292,Selpercatinib
CBNumber: CB34805442
Molecular Formula: C29H31N7O3
Formula Weight: 525.6
MOL File: 2152628-33-4.mol

Less

LOXO-292 Property

Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:20.0(Max Conc. mg/mL);38.05(Max Conc. mM)
form: A crystalline solid
pka: 14.00±0.29(Predicted)
InChI: InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3
InChIKey: XIIOFHFUYBLOLW-UHFFFAOYSA-N
SMILES: C12=C(C#N)C=NN1C=C(OCC(O)(C)C)C=C2C1=CC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 50mg
Price: $1100
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573122
Product name: LOXO-292(Selpercatinib)
Purity: >98%
Packaging: 100mg
Price: $1283.5
Updated: 2021/12/16

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 100mg
Price: $1800
Updated: 2021/12/16

Less

LOXO-292 Chemical Properties,Usage,Production

Uses

Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection").

Side effects

Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.

Selpercatinib may cause harm to a developing fetus or a newborn baby.

storage

Store at -20°C

Dosage

The recommended selpercatinib dose based on body weight is: (1) Less than 50 kg: 120 mg orally twice daily (2) 50 kg or greater: 160 mg orally twice daily

LOXO-292 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

LOXO-292 Suppliers

China 174 India 1 United States 5 Global 180

Changzhou Borl Biotechnology Co.,LTD

Tel: 13606124132;13656121842
Email: luyan0021@163.com
Country: China
ProdList: 219
Advantage: 58

Jinan Chuanbei Biotechnology Co., Ltd

Tel: 15269175648
Fax: 0531-67802093
Email: qingyan7590@163.com
Country: China
ProdList: 20
Advantage: 58

Shanghai tingchong biology science and technology co., ltd

Tel: 18964309092 18964309092
Email: 2769493375@qq.com
Country: China
ProdList: 2635
Advantage: 58

ZHENGZHOU TAIFENG PHARMACEUTICAL CO.,LTD

Tel: 182-3786-0830 19913859908
Email: 290833579@qq.com
Country: China
ProdList: 534
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 027-02759222918 13385289472
Email: Z13385289472@163.com
Country: China
ProdList: 3350
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD

Tel: 0531-18668921571 18668921571
Email: liujnlz@126.com
Country: China
ProdList: 20
Advantage: 58

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 462
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 9964
Advantage: 58

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

Wuhan Sunrise Technology Development Co., Ltd.

Tel: 027-027-83314682 13554138826
Fax: +86 (27) 8331-4682
Email: whsrtech@vip.163.com
Country: China
ProdList: 300
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 429
Advantage: 55

Anhui nuoquan pharmaceutical co. LTD

Tel: 0556-5032870 15705561919
Fax: 0556-5032869
Email: sujuan.mei@nuoquanpharm.com
Country: China
ProdList: 96
Advantage: 55

Shanghai Run-Biotech Co., Ltd.

Tel: 021-57171705 13817537615
Fax: QQ3095748324
Email: sales@run-biotech.com
Country: China
ProdList: 2603
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9636
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12357
Advantage: 58

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

Taizhou Ruixin Chemical Co., Ltd.

Tel: 0576-89085261 15867635987
Fax: 0576-89085262
Email: jasonhu09@163.com
Country: China
ProdList: 442
Advantage: 50

Twochem Co.Ltd

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 290
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1746
Advantage: 55

shandong XuanHong Pharmaceutical Technology Co.,Ltd

Tel: 0531-88801869 15562622698
Fax: 0531-88801867
Email: sciencechem@163.com
Country: China
ProdList: 274
Advantage: 55

ATK CHEMICAL COMPANY LIMITED

Tel: 3429815786 13301662590
Fax: +86-21-51619052
Email: sales@atkchemical.com
Country: China
ProdList: 10006
Advantage: 55

Artis Biotech Co. Ltd.

Tel: 19138486554 18582380095
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 3066
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Jinan Jianfeng Chemical Co., Ltd.

Tel: 0531-88110457 15562555968
Email: info@pharmachemm.com
Country: China
ProdList: 165
Advantage: 58

Enki Biopharmaceuticals(Shanghai) Limited

Tel: 021-57680965 13916707528
Fax: (21) 5768 0922
Email: yusu@enkibiopharma.com
Country: China
ProdList: 52
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9445
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 7590
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9859
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
Country: China
ProdList: 595
Advantage: 55

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 19967494293
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 314
Advantage: 58

Chemleader Biomedical Co., Limited.

Tel: 021-58180488
Fax: 021-58180499
Email: sales@MedChemLeader.com
Country: China
ProdList: 999
Advantage: 58

Shanghai Jinsheng Pharmaceutical Co., Ltd.

Tel: 13651960330
Email: xiangfeixia@jspharmatech.com
Country: China
ProdList: 311
Advantage: 58

WuHu Linze pharmaceutical Co.,Ltd.

Tel: 0553-0553-5802116 18356571950
Fax: -
Email: 2592492800@qq.com
Country: China
ProdList: 57
Advantage: 58

Beijing Mesochem Technology Co., Ltd.

Tel: 010-57862036 18811083386
Email: msales@mesochem.com
Country: China
ProdList: 189
Advantage: 58

Shandong Chenxi Pharmaceutical Co., Ltd.

Tel: +86-0531-88803416 13153166250
Fax: 0531-88803416
Email: sales@chemedpharma.com
Country: China
ProdList: 248
Advantage: 58

Shanghai Tube Pharmaceutical Co., Ltd.

Tel: 021-54338626 18017892860
Fax: 021-54338626
Email: sales@tubepharm.com
Country: China
ProdList: 2221
Advantage: 58

Changzhou Yongfeng Biomedicine Co. Ltd.

Tel: 15006117673
Fax: 2973592490@.com
Email: 2973592490@qq.com
Country: China
ProdList: 311
Advantage: 58

Guangzhou Belka Biological Technology Co., Ltd.

Tel: +86-18665676617
Fax: 18665676617
Country: China
ProdList: 958
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19105
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9651
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23556
Advantage: 58

Less

View Lastest Price from LOXO-292 manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Selpercatinib 2152628-33-4
Price: US $80.00-60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-15

hebei hongtan Biotechnology Co., Ltd

Product: LOXO-292 2152628-33-4
Price: US $50.00-30.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500
Release date: 2024-03-18

Jinan Million Pharmaceutical Co., Ltd

Product: Selpercatinib(LOXO-292) 2152628-33-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 30KG/M
Release date: 2023-08-15

2152628-33-4, LOXO-292Related Search:

Selumetinib Saracatinib LOXO-292 LOXO-195 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-6-bromopyridine Brigatinib Crizotinib 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Lorlatinib (PF-06463922) Olaparib Glecaprevir ABT-530 NBQX DISODIUM SALT SU14813 Futibatinib S-Ruxolitinib (INCB018424)

CPD2206

LOX-292

LOXO-292; LOXO292;LOXO 292

LOXO-292,Selpercatinib

Selpercatinib(LOXO-292)

6-?(2-?Hydroxy-?2-?methylpropoxy)?-?4-?[6-?[6-?[(6-?methoxy-?3-?pyridinyl)?methyl]?-?3,?6-?diazabicyclo[3.1.1]?hept-?3-?yl]?-?3-?pyridinyl]?pyrazolo[1,?5-?a]?pyridine-?3-?carbonitrile

Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-

LOXO-292 USP/EP/BP

6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile

Inhibitor LOXO-292

ARRY-192)

Selpercatinib (LOXO-292, ARRY-192)

LOX0292

Serpatinib

SELPERCATINIB

LOXO-292

13C,2H3]-Selpercatinib

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl) methyll-N-methylamino]-2-thenoyll-L-glutamate

2152628-33-4

API

2152628-33-4