LOXO-292

Product Name: LOXO-292
CAS No.: 2152628-33-4
Chemical Name: LOXO-292
Synonyms: SELPERCATINIB;LOX-292;CPD2206;LOX0292;LOXO-292;ARRY-192);Serpatinib;LOXO-292 USP/EP/BP;Inhibitor LOXO-292;LOXO-292,Selpercatinib
CBNumber: CB34805442
Molecular Formula: C29H31N7O3
Formula Weight: 525.6
MOL File: 2152628-33-4.mol

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LOXO-292 Property

Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:20.0(Max Conc. mg/mL);38.05(Max Conc. mM)
form: A crystalline solid
pka: 14.00±0.29(Predicted)
InChI: InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3
InChIKey: XIIOFHFUYBLOLW-UHFFFAOYSA-N
SMILES: C12=C(C#N)C=NN1C=C(OCC(O)(C)C)C=C2C1=CC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 50mg
Price: $1100
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573122
Product name: LOXO-292(Selpercatinib)
Purity: >98%
Packaging: 100mg
Price: $1283.5
Updated: 2021/12/16

ChemScene

Product number: CS-0084279
Product name: Selpercatinib
Purity: 99.87%
Packaging: 100mg
Price: $1800
Updated: 2021/12/16

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LOXO-292 Chemical Properties,Usage,Production

Uses

Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection").

Side effects

Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.

Selpercatinib may cause harm to a developing fetus or a newborn baby.

storage

Store at -20°C

Dosage

The recommended selpercatinib dose based on body weight is: (1) Less than 50 kg: 120 mg orally twice daily (2) 50 kg or greater: 160 mg orally twice daily

LOXO-292 Preparation Products And Raw materials

Raw materials

Preparation Products

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LOXO-292 Suppliers

China 177 India 1 United States 5 Global 183

Changzhou Borl Biotechnology Co.,LTD

Tel: 13606124132;13656121842
Email: luyan0021@163.com
Country: China
ProdList: 220
Advantage: 58

Jinan Chuanbei Biotechnology Co., Ltd

Tel: 15269175648
Fax: 0531-67802093
Email: qingyan7590@163.com
Country: China
ProdList: 20
Advantage: 58

Shanghai tingchong biology science and technology co., ltd

Tel: 18964309092 18964309092
Email: 2769493375@qq.com
Country: China
ProdList: 2635
Advantage: 58

ZHENGZHOU TAIFENG PHARMACEUTICAL CO.,LTD

Tel: 182-3786-0830 19913859908
Email: 290833579@qq.com
Country: China
ProdList: 534
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 027-02759222918 13385289472
Email: Z13385289472@163.com
Country: China
ProdList: 4607
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD

Tel: 0531-18668921571 18668921571
Email: liujnlz@126.com
Country: China
ProdList: 20
Advantage: 58

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 463
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 10003
Advantage: 58

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7639
Advantage: 55

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View Lastest Price from LOXO-292 manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: LOXO-292 2152628-33-4
Price: US $50.00-30.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500
Release date: 2024-05-13

hebei hongtan Biotechnology Co., Ltd

Product: Selpercatinib 2152628-33-4
Price: US $80.00-60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-05-13

Jinan Million Pharmaceutical Co., Ltd

Product: Selpercatinib(LOXO-292) 2152628-33-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 30KG/M
Release date: 2023-08-15

2152628-33-4, LOXO-292Related Search:

Selumetinib Saracatinib LOXO-292 LOXO-195 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-6-bromopyridine Brigatinib Crizotinib 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Lorlatinib (PF-06463922) Olaparib Glecaprevir ABT-530 NBQX DISODIUM SALT SU14813 Futibatinib S-Ruxolitinib (INCB018424)

CPD2206

LOX-292

LOXO-292; LOXO292;LOXO 292

LOXO-292,Selpercatinib

Selpercatinib(LOXO-292)

6-?(2-?Hydroxy-?2-?methylpropoxy)?-?4-?[6-?[6-?[(6-?methoxy-?3-?pyridinyl)?methyl]?-?3,?6-?diazabicyclo[3.1.1]?hept-?3-?yl]?-?3-?pyridinyl]?pyrazolo[1,?5-?a]?pyridine-?3-?carbonitrile

Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-

LOXO-292 USP/EP/BP

6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile

Inhibitor LOXO-292

ARRY-192)

Selpercatinib (LOXO-292, ARRY-192)

LOX0292

Serpatinib

SELPERCATINIB

LOXO-292

13C,2H3]-Selpercatinib

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl) methyll-N-methylamino]-2-thenoyll-L-glutamate

2152628-33-4

GS

API

2152628-33-4