Binding Mode
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LOXO-292

Binding Mode
Product Name
LOXO-292
CAS No.
2152628-33-4
Chemical Name
LOXO-292
Synonyms
SELPERCATINIB;LOX-292;CPD2206;LOX0292;Orapani;LOXO-292;ARRY-192);Serpatinib;LOXO-292 USP/EP/BP;Inhibitor LOXO-292
CBNumber
CB34805442
Molecular Formula
C29H31N7O3
Formula Weight
525.6
MOL File
2152628-33-4.mol
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LOXO-292 Property

Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:20.0(Max Conc. mg/mL);38.05(Max Conc. mM)
form 
A crystalline solid
pka
14.00±0.29(Predicted)
color 
White to off-white
InChI
InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3
InChIKey
XIIOFHFUYBLOLW-UHFFFAOYSA-N
SMILES
C12=C(C#N)C=NN1C=C(OCC(O)(C)C)C=C2C1=CC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0084279
Product name
Selpercatinib
Purity
99.87%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0084279
Product name
Selpercatinib
Purity
99.87%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0084279
Product name
Selpercatinib
Purity
99.87%
Packaging
50mg
Price
$1100
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573122
Product name
LOXO-292(Selpercatinib)
Purity
>98%
Packaging
100mg
Price
$1283.5
Updated
2021/12/16
ChemScene
Product number
CS-0084279
Product name
Selpercatinib
Purity
99.87%
Packaging
100mg
Price
$1800
Updated
2021/12/16
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LOXO-292 Chemical Properties,Usage,Production

Binding Mode

In the co-crystal structure of selpercatinib-RET kinase, the pyrazolopyridine occupies the adenosine pocket, forming a direct hydrogen bond between N1 and amide NH of Ala807 and an indirect hydrogen bond between C6 ether oxygen and amide NH of Gly810 via a bound water molecule. In addition, one piperazine nitrogen also interact with one water molecule (Figs. 3, 4).

Uses

Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection").

brand name

Retevmo

General Description

Class: receptor tyrosine kinase; Treatment: RET-altered lung/thyroid cancers; Other name: ARRY-192, LOXO-292; Oral bioavailability = 73%; Elimination half-life = 32 h; Protein binding = 97%

Side effects

Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.

Selpercatinib may cause harm to a developing fetus or a newborn baby.

target

RET

storage

Store at -20°C

Dosage

The recommended selpercatinib dose based on body weight is: (1) Less than 50 kg: 120 mg orally twice daily (2) 50 kg or greater: 160 mg orally twice daily

LOXO-292 Preparation Products And Raw materials

Raw materials

Preparation Products

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LOXO-292 Suppliers

Chunchuang (Wuhan) Technology Co., Ltd
Tel
15342225168
Email
yutianchun2007@126.com
Country
China
ProdList
10003
Advantage
58
Jinan Chuanbei Biotechnology Co., Ltd
Tel
18654547380; 15269175648
Fax
0531-67802093
Email
qingyan7590@163.com
Country
China
ProdList
22
Advantage
58
ZHENGZHOU TAIFENG PHARMACEUTICAL CO.,LTD
Tel
182-3786-0830 19913859908
Email
290833579@qq.com
Country
China
ProdList
531
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq:1580084073
Email
1580084073@qq.com
Country
China
ProdList
650
Advantage
58
Changzhou Borl Biotechnology Co.,LTD
Tel
13606124132;13656121842
Email
luyan0021@163.com
Country
China
ProdList
219
Advantage
58
Houxu Chemical (Shandong) Co., Ltd
Tel
18295613325
Email
2026425403@qq.com
Country
China
ProdList
18
Advantage
58
JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD
Tel
18668921571 18668921571
Email
liujnlz@126.com
Country
China
ProdList
24
Advantage
58
Enki Biopharmaceuticals(Shanghai) Limited
Tel
021-57680965 13916707528
Fax
(21) 5768 0922
Email
yusu@enkibiopharma.com
Country
China
ProdList
44
Advantage
55
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
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View Lastest Price from LOXO-292 manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
LOXO-292 2152628-33-4
Price
US $50.00-30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2024-05-13
hebei hongtan Biotechnology Co., Ltd
Product
Selpercatinib 2152628-33-4
Price
US $80.00-60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-05-13
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Selpercatinib 2152628-33-4
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-24

2152628-33-4, LOXO-292Related Search:


  • CPD2206
  • LOX-292
  • LOXO-292; LOXO292;LOXO 292
  • LOXO-292,Selpercatinib
  • Selpercatinib(LOXO-292)
  • 6-?(2-?Hydroxy-?2-?methylpropoxy)?-?4-?[6-?[6-?[(6-?methoxy-?3-?pyridinyl)?methyl]?-?3,?6-?diazabicyclo[3.1.1]?hept-?3-?yl]?-?3-?pyridinyl]?pyrazolo[1,?5-?a]?pyridine-?3-?carbonitrile
  • Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-
  • LOXO-292 USP/EP/BP
  • 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile
  • Inhibitor LOXO-292
  • ARRY-192)
  • Selpercatinib (LOXO-292, ARRY-192)
  • LOX0292
  • Serpatinib
  • SELPERCATINIB
  • LOXO-292
  • 13C,2H3]-Selpercatinib
  • Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl) methyll-N-methylamino]-2-thenoyll-L-glutamate
  • Orapani
  • Selpatinib LOXO-292
  • 2152628-33-4
  • GS
  • API
  • 2152628-33-4