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ChemicalBook > CAS DataBase List > Tetrahydro-4H-pyran-4-one

Tetrahydro-4H-pyran-4-one

Description Application
Product Name
Tetrahydro-4H-pyran-4-one
CAS No.
29943-42-8
Chemical Name
Tetrahydro-4H-pyran-4-one
Synonyms
dihydro-2H-pyran-4(3H)-one;Oxan-4-one;TETRAHYDROPYRAN-4-ONE;4-THP;4-OXOTETRAHYDROPYRAN;4H-Pyran-4-one, tetrahydro-;EOS-60523;1KG,10KG,25KG;TETRAHYDRO-GAMM;4-Oxacyclohexanone
CBNumber
CB3703050
Molecular Formula
C5H8O2
Formula Weight
100.12
MOL File
29943-42-8.mol
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Tetrahydro-4H-pyran-4-one Property

Boiling point:
166-166.5 °C (lit.)
Density 
1.084 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.452(lit.)
Flash point:
134 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
color 
Clear colorless to pale yellow
Water Solubility 
MISCIBLE
BRN 
106463
InChIKey
JMJRYTGVHCAYCT-UHFFFAOYSA-N
CAS DataBase Reference
29943-42-8(CAS DataBase Reference)
NIST Chemistry Reference
4H-Pyran-4-one, tetrahydro-(29943-42-8)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
10-36/37/38
Safety Statements 
24/25-36-26
RIDADR 
UN 1224 3/PG 3
WGK Germany 
3
F 
10
Hazard Note 
Keep Cold/Flammable/Irritant
HazardClass 
3.2
PackingGroup 
III
HS Code 
29329995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
198242
Product name
Tetrahydro-4H-pyran-4-one
Purity
99%
Packaging
1g
Price
$41.9
Updated
2024/03/01
Sigma-Aldrich
Product number
198242
Product name
Tetrahydro-4H-pyran-4-one
Purity
99%
Packaging
5g
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
T1806
Product name
Tetrahydro-4H-pyran-4-one
Purity
>95.0%(GC)
Packaging
1g
Price
$37
Updated
2024/03/01
TCI Chemical
Product number
T1806
Product name
Tetrahydro-4H-pyran-4-one
Purity
>95.0%(GC)
Packaging
5g
Price
$104
Updated
2024/03/01
Alfa Aesar
Product number
A19010
Product name
Tetrahydro-4H-pyran-4-one
Purity
98%
Packaging
1g
Price
$41.65
Updated
2024/03/01
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Tetrahydro-4H-pyran-4-one Chemical Properties,Usage,Production

Description

Tetrahydro-4H-pyran-4-one is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes.
The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. Tetrahydro-4H-pyran-4-one is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3.

Application

Tetrahydro-4-pyrone is used in organic synthesis as a building block for more complex chemical structures because it participates in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid and it undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of penicillins and in a ring of vitamin D3. Additionally, tetrahydro-4-pyrone is used as solvents in some reactions.

Chemical Properties

colorless to light yellow liquid

Uses

Tetrahydro-4-pyrone is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions.

Purification Methods

Purify the pyrone by repeated distillation, preferably in a vacuum. [Baker J Chem Soc 296 1944, IR: Olsen & Bredoch Chem Ber 91 1589 1958.] The oxime has m 87-88o and b 110-111o/13mm [Cornubert et al. Bull Soc Chim Fr 36 1950]. The 4-nitrophenylhydrazone forms orange-brown needles from EtOH, m 186o [Cawley & Plant J Chem Soc 1214 1938]. [Beilstein 17 I 131, 17 II 287, 17 III/IV 4171, 17/9 V 21.]

Tetrahydro-4H-pyran-4-one Preparation Products And Raw materials

Raw materials

Heptane Ethylene Copper Ethanol Acetone Phosphoric acid Diethyl oxalate Nickel 2,2'-Bipyridine Sodium ethoxide 1,2,3,4-Tetrahydronaphthalene Sodium phosphate monobasic Aluminum chloride Dibutyl phthalate Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide 3-Chloropropionyl chloride Magnesium sulfate PETROLEUM ETHER

Preparation Products

4-Aminotetrahydropyran hydrochloride 4-Aminotetrahydropyran 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL E-4-Hexen-1-ol
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View Lastest Price from Tetrahydro-4H-pyran-4-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tetrahydro-4H-pyran-4-one 29943-42-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
30tons/month
Release date
2023-02-22
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Tetrahydro-4H-pyran-4-one 29943-42-8
Price
US $65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-07
Shanghai Yongzeng Technology Co.,Ltd
Product
Tetrahydro-4H-pyran-4-One 29943-42-8
Price
US $370.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kgs
Release date
2024-09-02

29943-42-8, Tetrahydro-4H-pyran-4-oneRelated Search:

Tetrahydropyran Tetrahydrothiophen-3-one 4-Aminotetrahydropyran Centchroman Tetrahydro-4-pyranol 5-Formylsalicylic acid TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Tetrahydrothiopyran-4-one Tetrahydro-2H-pyran-4-carboxylic acid Tetrahydropyranyl-4-acetic acid Tetrahydro-4H-Pyran-4-one TETRAHYDROPYRAN-2-METHANOL Ethyl Tetrahydropyran-4-Carboxylate ETHYL TETRAHYDROPYRAN-4-YL-ACETATE (TETRAHYDRO-FURAN-3-YL)-ACETIC ACID Tetrahydropyran-4-carbaldehyde Tetrahydro-2H-pyran-4-carbonyl chloride

  • Tetrahydro-4-pyrone
  • TETRAHYDRO-GAMMA-PYRONE
  • TETRAHYDROPYRAN-4-ONE
  • TETRAHYDRO-4H-PYRAN-4-ONE
  • TETRAHYDRO-2H-PYRAN-4-ONE
  • TetrahydroHpyranone
  • 4-OXOTETRAHYDROPYRAN
  • 4-THP
  • Tetrahydropyran-4-on
  • Tetrahydro-4H-pyran-4-one,98%
  • Tetrahydo-4H-pyran-4-one
  • 4H-Pyran-4-one, tetrahydro-
  • Tetrahydro-4H-pyran-4-one 97%
  • Tetranydropyran-4-one
  • Tetrahydro-4-H-prran-one
  • Tetrahydro-4H-pran-4-one
  • Tetrahydro-4H-pyran-4-one, 97+%
  • Four hydrogen pyran - 4 - ketone
  • Tetrahydro-4<i>H</i>-pyran-4-one
  • 4-tetrahydropyranone
  • EOS-60523
  • TETRAHYDRO-GAMM
  • 1KG,10KG,25KG
  • 2,3,5,6-Tetrahydropyran-4-one
  • 3,5,6-Trihydro-2H-pyran-4-one
  • Oxan-4-one
  • 4-Oxotetrahydopyran
  • 2,3,5,6-Tetrahydro-4H-pyran-4-one
  • 2,3,5,6-Tetrahydro-4-pyranone
  • 4-Oxacyclohexanone
  • Tetrahydro-4-pyranone
  • Tetrahydro-4H-pyran-4-one,99%
  • dihydro-2H-pyran-4(3H)-one
  • Tetrahydro-4H-pyran-4-one,4-Oxotetrahydropyran
  • Tetrahydro-4H-pyran-
  • 4-Oxotetrahydropyran(Tetrahydropyran-4-one)
  • etrahydro-4H-pyran-4-one
  • Tetrahydro-4H-pyran-4-one, 99% 5GR
  • TETRAHYDRO-4H-PYRAN-4-ONE FOR SYNTHESIS
  • 4-Oxotrtrahydropyran
  • 4-Oxotetrahydro-4H-pyran
  • Tetrahydro-4H-Pyran-4-One (4-THP)
  • Tetrahydro-4H-pyran-4-one, 98%, for synthesis
  • Tetrahydro-4H-pyran-4-one ISO 9001：2015 REACH
  • Tetrahydropyranone
  • 29943-42-8
  • C5H8O2
  • KETONE
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrans
  • blocks
  • Oxygen cyclic compounds
  • Pyrans, Piperidines &Piperazines
  • Carbonyl Compounds
  • Ketone
  • Pyrans, Piperidines & Piperazines
  • Heterocycles