ChemicalBook > CAS DataBase List > 6-CHLORO-2-PICOLINIC ACID METHYL ESTER

6-CHLORO-2-PICOLINIC ACID METHYL ESTER

Product Name
6-CHLORO-2-PICOLINIC ACID METHYL ESTER
CAS No.
6636-55-1
Chemical Name
6-CHLORO-2-PICOLINIC ACID METHYL ESTER
Synonyms
AKOS BBS-00004651;Sorafenib Impurity 117;methyl 6-chloropicolinate;6-Chloropicolinic acid methyl ester;methyl (6-chloropyridin-2-yl)acetate;methyl 6-chloro-2-pyridinecarboxylate;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;2-chloropyridine-6-carboxylate methyl;methyl 2-(6-chloropyridin-2-yl)acetate;6-CHLORO-2-PICOLINIC ACID METHYL ESTER
CBNumber
CB3780710
Molecular Formula
C7H6ClNO2
Formula Weight
171.58
MOL File
6636-55-1.mol
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6-CHLORO-2-PICOLINIC ACID METHYL ESTER Property

Melting point:
93-94°
Boiling point:
275.8±20.0 °C(Predicted)
Density 
1.294±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-1.03±0.10(Predicted)
form 
Solid
color 
Pale yellow
Water Solubility 
Slightly soluble in water.
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2640
Product name
Methyl 6-Chloro-2-pyridinecarboxylate
Purity
>98.0%(GC)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
M2640
Product name
Methyl 6-Chloro-2-pyridinecarboxylate
Purity
>98.0%(GC)
Packaging
5g
Price
$31
Updated
2024/03/01
Alfa Aesar
Product number
H64023
Product name
Methyl 6-chloropyridine-2-carboxylate, 95%
Packaging
5g
Price
$47.7
Updated
2024/03/01
Alfa Aesar
Product number
H64023
Product name
Methyl 6-chloropyridine-2-carboxylate, 95%
Packaging
25g
Price
$177
Updated
2024/03/01
Alfa Aesar
Product number
H64023
Product name
Methyl 6-chloropyridine-2-carboxylate, 95%
Packaging
100g
Price
$484
Updated
2021/12/16
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6-CHLORO-2-PICOLINIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.

Synthesis Reference(s)

Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867

Synthesis

6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).

6-CHLORO-2-PICOLINIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-2-PICOLINIC ACID METHYL ESTER Suppliers

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View Lastest Price from 6-CHLORO-2-PICOLINIC ACID METHYL ESTER manufacturers

Henan Fengda Chemical Co., Ltd
Product
6-CHLORO-2-PICOLINIC ACID METHYL ESTER 6636-55-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Henan Aochuang Chemical Co.,Ltd.
Product
6-CHLORO-2-PICOLINIC ACID METHYL ESTER 6636-55-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Dideu Industries Group Limited
Product
6-CHLORO-2-PICOLINIC ACID METHYL ESTER 6636-55-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25

6636-55-1, 6-CHLORO-2-PICOLINIC ACID METHYL ESTERRelated Search:

6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE Methyl 6-bromonicotinate METHYL 6-FORMYLNICOTINATE methyl 6-chloropyrimidine-4-carboxylate Methyl 6-bromoisoquinoline-1-carboxylate Methyl 6-bromohexanoate Methyl 6-chloronicotinate METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE methyl 6-methylpyridine-2-carboxylate 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 6-bromo-2-naphthoate 6-METHYLPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 2-Chloro-6-pyrazinecarboxylic acid methyl ester Methyl 6-HydroxypyriMidine-4-carboxylate Methyl 6-methylnicotinate Methyl 3-chloropicolinate 6-Chloropicolinic acid

  • Methyl 6-Chloropyridine-2-carboxylate, 97+%
  • METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE
  • AKOS BBS-00004651
  • 6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
  • 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
  • 6-Chloro-2-pyridinecarboxylic acid methyl ester
  • 6-Chloropicolinic acid methyl ester
  • 2-Pyridinecarboxylic acid, 6-chloro-, methyl ester
  • methyl 6-chloro-2-pyridinecarboxylate
  • methyl 2-(6-chloropyridin-2-yl)acetate
  • methyl 6-chloropicolinate
  • methyl (6-chloropyridin-2-yl)acetate
  • 2-chloropyridine-6-carboxylate methyl
  • 6-chloro-2-picolonic acid methyl ester
  • Methyl 6-chloropicolinate, 2-Chloro-6-(methoxycarbonyl)pyridine
  • 6-Chloro-2-picolinic acid methyl ester Solution
  • Methyl 6-Chloro-2-pyridinecarboxylate &gt
  • Methyl6-chloropyridine-2-carboxylate,95%
  • 6-CHLORO-2-PICOLINIC ACID METHYL ESTER ISO 9001：2015 REACH
  • Sorafenib Impurity 117
  • 6-Chloro-2-picolinic acid methyl ester Solution in Hexane
  • Methyl 6-chloro-2-pyridinecarboxylate,Methyl 6-chloropicolinate,6-Chloro-2-pyridinecarboxylic acid methyl ester,6-Chloropicolinic acid methyl ester,2-Pyridinecarboxylic acid, 6-chloro-, methyl ester,methyl 6-chloropyridine-2-carboxylate,6-chloro-2-picolinic acid methyl ester,METHYL 6-CHLORO-2-PYRIDINECARBOXYLATE
  • Methyl 6-Chloropyridine-2-carboxylate, 97+% METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE,AKOS BBS-00004651,6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER,6-CHLORO-2-PICOLINIC ACID METHYL ESTER,6-Chloro-2-pyridinecarboxylic acid methyl ester,6-Chloropicolinic acid methyl ester,2-Pyridinecarboxylic acid, 6-chloro-, methyl ester,methyl 6-chloro-2-pyridinecarboxylate,methyl 2-(6-chloropyridin-2-yl)acetate,methyl 6-chloropicolinate,methyl (6-chloropyridin-2-yl)acetate,2-chloropyridine-6-carboxylate methyl,
  • 6636-55-1
  • Picolinic acid series