6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- Product Name
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CAS No.
- 6636-55-1
- Chemical Name
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- Synonyms
- AKOS BBS-00004651;Sorafenib Impurity 117;methyl 6-chloropicolinate;6-Chloropicolinic acid methyl ester;methyl (6-chloropyridin-2-yl)acetate;methyl 6-chloro-2-pyridinecarboxylate;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;2-chloropyridine-6-carboxylate methyl;methyl 2-(6-chloropyridin-2-yl)acetate;6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CBNumber
- CB3780710
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 6636-55-1.mol
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Property
- Melting point:
- 93-94°
- Boiling point:
- 275.8±20.0 °C(Predicted)
- Density
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.03±0.10(Predicted)
- form
- Solid
- color
- Pale yellow
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H6ClNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3
- InChIKey
- TWUXBVMXSBEKHA-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(Cl)=CC=C1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2640
- Product name
- Methyl 6-Chloro-2-pyridinecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- M2640
- Product name
- Methyl 6-Chloro-2-pyridinecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- C379663
- Product name
- 6-Chloro-2-picolinicacidmethylester
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C379663
- Product name
- 6-Chloro-2-picolinicacidmethylester
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 048113
- Product name
- Methyl 6-chloro-2-pyridinecarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $23
- Updated
- 2021/12/16
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.
Synthesis Reference(s)
Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867
Synthesis
6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
References
[1] Patent: WO2004/26871, 2004, A1. Location in patent: Page 43
[2] Patent: WO2007/58482, 2007, A1. Location in patent: Page/Page column 47
[3] Patent: WO2013/102431, 2013, A1. Location in patent: Page/Page column 117
[4] Patent: WO2015/6592, 2015, A1. Location in patent: Page/Page column 52; 53
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 6-CHLORO-2-PICOLINIC ACID METHYL ESTER manufacturers
- Product
- Methyl 6-chloropicolinate 6636-55-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER 6636-55-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER 6636-55-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09